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1. (WO2015048009) SYSTEM AND METHOD FOR LASER LYSIS

Pub. No.:    WO/2015/048009    International Application No.:    PCT/US2014/056960
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Wed Sep 24 01:59:59 CEST 2014
IPC: G01N 33/48
G01N 33/487
G01N 33/50
Applicants: ARIZONA BOARD OF REGENTS ON BEHALE OF ARIZONA STATE UNIVERSITY
MELDRUM, Deirdre
CHAO, Shih-Hui, (Joseph)
TRAN, Thai
KELBAUSKAS, Laimonas
HOUKAL, Jeff
HATCH, Andrew
GAO, Weimin
RICHARDSON, David, Wayne
Inventors: MELDRUM, Deirdre
CHAO, Shih-Hui, (Joseph)
TRAN, Thai
KELBAUSKAS, Laimonas
HOUKAL, Jeff
HATCH, Andrew
GAO, Weimin
RICHARDSON, David, Wayne
Title: SYSTEM AND METHOD FOR LASER LYSIS
Abstract:
The present invention provides a system and method for lysing individual cells in situ, including the steps of capturing a tissue sample comprising a cellular content, subjecting the tissue sample to a stream of continuous fluid flow, lysing a selected area of the tissue sample with a laser, thereby releasing at least a portion of the cellular content from the tissue sample, recovering at least one target molecule from the cellular content in the stream, and processing the at least one target molecule.