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1. (WO2015047763) COMPOSITION COMPRISING AN ORGANIC LIQUID DILUENT AND A SPECIFIC HYDROXYALKYL METHYLCELLULOSE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/047763 International Application No.: PCT/US2014/055574
Publication Date: 02.04.2015 International Filing Date: 15.09.2014
Chapter 2 Demand Filed: 27.04.2015
IPC:
A61K 9/08 (2006.01) ,A61K 9/48 (2006.01) ,A61K 47/10 (2006.01) ,A61K 47/38 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
Applicants:
DOW GLOBAL TECHNOLOGIES LLC [US/US]; 2040 Dow Center Midland, MI 48674, US
Inventors:
BRACKHAGEN, Meinolf; DE
ADDEN, Roland; DE
KNARR, Matthias; DE
Agent:
MAURER, Charles; US
GOLDENER, Beatrice; Dow International Holdings S.A. Bachtobelstrasse 3 8810 Horgen, CH
Priority Data:
61/882,04025.09.2013US
Title (EN) COMPOSITION COMPRISING AN ORGANIC LIQUID DILUENT AND A SPECIFIC HYDROXYALKYL METHYLCELLULOSE
(FR) COMPOSITION COMPRENANT UN DILUANT LIQUIDE ORGANIQUE ET UNE MÉTHYLCELLULOSE D'HYDROXYALKYLE SPÉCIFIQUE
Abstract:
(EN) A liquid composition which comprises an organic liquid diluent and a hydroxyalkyl methylcellulose which has a certain distribution of substituted hydroxyalkoxyl groups and unsubstituted hydroxyalkoxyl groups is stable over an extended time period. In the hydroxyalkyl methylcellulose hydroxyalkoxyl groups are classified into a fraction (A) and a fraction (B), wherein fraction (A) represents the sum of all molar fractions of substituted hydroxyalkoxyl groups having hydroxyl groups substituted further with methoxyl groups and fraction (B) represents the sum of all molar fractions of unsubstituted hydroxyalkoxyl groups having hydroxyl groups not substituted further with methoxyl groups and wherein the ratio fraction (A)/fraction (B) is at least 0.30. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one hydroxypropyl methylcellulose by spray-drying.
(FR) L’invention concerne une composition liquide qui comprend un diluant liquide organique et une méthylcellulose d’hydroxyalkyle contenant groupes hydroxyalkoxyle substitués et des groupes hydroxyalkoxyle non substitués selon une répartition donnée, et qui est stable sur une durée prolongée. Les groupes hydroxyalkoxyle de la méthylcellulose d’hydroxyalkyle constituent une fraction (A) et une fraction (B), la fraction (A) représentant la somme de toutes les fractions molaires des groupes hydroxyalkoxyle substitués contenant des groupes hydroxyle également substitués par des groupes méthoxyle, et la fraction (B) représentant la somme de toutes les fractions molaires des groupes hydroxyalkoxyle non substitués contenant des groupes hydroxyle non substitués par des groupes méthoxyle, le rapport fraction (A)/fraction (B) valant au moins 0,30. La composition liquide est utilisée pour préparer une dispersion solide comprenant au moins un principe actif dans au moins une méthylcellulose d’hydroxypropyle par séchage par pulvérisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)