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1. (WO2015047062) FUSED PROTEINS OF GRANULOCYTE COLONY-STIMULATING FACTOR WITH OTHER PARTNERS OF GROWTH FACTOR, PREFERABLY WITH STEM CELL FACTOR, AND METHOD OF PREPARATION THEREOF

Pub. No.:    WO/2015/047062    International Application No.:    PCT/LT2014/000006
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Wed Apr 16 01:59:59 CEST 2014
IPC: C07K 14/535
C07K 14/475
Applicants: UAB PROFARMA
Inventors: PESLIAKAS, Jonas Henrikas
PLECKAITYTE, Milda
MISTINIENE, Edita
ZVIRBLYTE, Gitana
PETREIKYTE, Indre
LEIVA, Audrius
STIRKE, Arunas
ZVIRBLIS, Gintautas
Title: FUSED PROTEINS OF GRANULOCYTE COLONY-STIMULATING FACTOR WITH OTHER PARTNERS OF GROWTH FACTOR, PREFERABLY WITH STEM CELL FACTOR, AND METHOD OF PREPARATION THEREOF
Abstract:
Abstract Invention is disclosing method for preparation and biological properties of fused proteins, mainly heterodimer of granulocyte colony-stimulating factor and stem cell factor. Multimer constructions according to this invention may be used in therapy, since are characterized by synergy of in vivo functioning and extended circulation half-life in comparison to each separate protein monomer.