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1. (WO2015046857) COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE THYROID DISEASES

Pub. No.:    WO/2015/046857    International Application No.:    PCT/KR2014/008832
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Wed Sep 24 01:59:59 CEST 2014
IPC: A61K 31/155
A61P 5/00
Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
연세대학교 산학협력단
Inventors: LEE, Eun Jig
이은직
LEE, Hyun Jung
이현정
KU, Cheol Ryong
구철룡
Title: COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE THYROID DISEASES
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating autoimmune thyroid diseases, comprising a biguanide derivative and, more specifically, metformin as an active ingredient. The composition of the present invention can effectively treat or improve various pathologic conditions caused by thyroid autoantibody, for example thyroid-associated ophthalmopathy, by significantly inhibiting hyaluronan production and adipocyte differentiation while having a low cytotoxicity.