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1. (WO2015046653) NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF

Pub. No.:    WO/2015/046653    International Application No.:    PCT/KR2013/008740
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Tue Oct 01 01:59:59 CEST 2013
IPC: C07D 487/04
A61K 31/4985
A61P 35/00
A61P 3/00
A61P 9/00
A61P 29/00
Applicants: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
한국화학연구원
HANDOK INC.
주식회사 한독
Inventors: JUNG, Hee Jung
정희정
HA, Jae Du
하재두
CHO, Sung Yun
조성윤
KIM, Hyoung Rae
김형래
LEE, Kwang Ho
이광호
LEE, Chong Ock
이정옥
CHOI, Sang Un
최상운
PARK, Chi Hoon
박지훈
Title: NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF
Abstract:
The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof; to a pharmaceutical composition containing the same as an active ingredient for inhibiting c-Met tyrosine kinase activity; and to a pharmaceutical composition for preventing or alleviating a hyper-proliferative disorder. The present invention efficiently inhibits c-Met tyrosine kinase activity, and thus can be useful as a therapeutic agent against various hyper-proliferative disorders associated with excessive cellular proliferation and growth due to abnormal kinase activity, for example, cancer, psoriasis, rheumatoid arthritis, or diabetic retinopathy.