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|1. (WO2015046223) DISINTEGRATING PARTICLE COMPOSITION PRODUCED BY TWO-STAGE WET GRANULATION PROCESS, AND INTRAORALLY DISINTEGRATING TABLET CONTAINING SAME COMPOSITION|
|Title:||DISINTEGRATING PARTICLE COMPOSITION PRODUCED BY TWO-STAGE WET GRANULATION PROCESS, AND INTRAORALLY DISINTEGRATING TABLET CONTAINING SAME COMPOSITION|
The objective of the present invention is to provide a disintegrating particle composition usable in an intraorally disintegrating tablet having excellent tablet hardness and disintegration ability, a production method therefor, and the like. The present invention relates to a method for producing a disintegrating particle composition, the produced disintegrating particle composition, an intraorally disintegrating tablet containing the disintegrating particle composition and a medicinal ingredient, and the like. The disintegrating particle composition contains three components: a first disintegrant component comprising a disintegrant having a sedimentation volume of 4.0 cm3/g or greater with respect to water; a second disintegrant component different from the first disintegrant; and a diluent. The method is characterized by the inclusion of a first wet granulation step wherein any two components from among the three components are used, and a second wet granulation step wherein at least the remaining component not used in the first wet granulation step among the three components and a granulated substance obtained in the first wet granulation step are used.