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1. (WO2015046223) DISINTEGRATING PARTICLE COMPOSITION PRODUCED BY TWO-STAGE WET GRANULATION PROCESS, AND INTRAORALLY DISINTEGRATING TABLET CONTAINING SAME COMPOSITION

Pub. No.:    WO/2015/046223    International Application No.:    PCT/JP2014/075241
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Thu Sep 25 01:59:59 CEST 2014
IPC: A61K 47/38
A61K 9/20
A61K 47/32
A61K 47/36
Applicants: DAICEL CORPORATION
株式会社ダイセル
Inventors: HIRAMURA Takahiro
平邑 隆弘
IKURA Kiyoshi
以倉 聖
ITAYA Sae
板谷 左枝
OKABAYASHI Tomohito
岡林 智仁
HASHIKAWA Naohiro
橋川 尚弘
SAKAGUCHI Anan
坂口 阿南
Title: DISINTEGRATING PARTICLE COMPOSITION PRODUCED BY TWO-STAGE WET GRANULATION PROCESS, AND INTRAORALLY DISINTEGRATING TABLET CONTAINING SAME COMPOSITION
Abstract:
The objective of the present invention is to provide a disintegrating particle composition usable in an intraorally disintegrating tablet having excellent tablet hardness and disintegration ability, a production method therefor, and the like. The present invention relates to a method for producing a disintegrating particle composition, the produced disintegrating particle composition, an intraorally disintegrating tablet containing the disintegrating particle composition and a medicinal ingredient, and the like. The disintegrating particle composition contains three components: a first disintegrant component comprising a disintegrant having a sedimentation volume of 4.0 cm3/g or greater with respect to water; a second disintegrant component different from the first disintegrant; and a diluent. The method is characterized by the inclusion of a first wet granulation step wherein any two components from among the three components are used, and a second wet granulation step wherein at least the remaining component not used in the first wet granulation step among the three components and a granulated substance obtained in the first wet granulation step are used.