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1. (WO2015045333) MYOCARDIAL CELL PROLIFERATION-INDUCER, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND METHOD FOR PRODUCING MYOCARDIAL CELLS

Pub. No.:    WO/2015/045333    International Application No.:    PCT/JP2014/004785
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Thu Sep 18 01:59:59 CEST 2014
IPC: A61K 38/00
A61K 38/22
A61L 27/00
A61P 9/10
A61P 9/12
C12N 5/071
C07K 14/58
C12N 15/09
Applicants: CMIC HOLDINGS CO., LTD.
シミックホールディングス株式会社
NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
独立行政法人国立循環器病研究センター
Inventors: MOCHIZUKI, Naoki
望月 直樹
TOKUDOME, Takeshi
徳留 健
OOTANI, Kentaro
大谷 健太郎
Title: MYOCARDIAL CELL PROLIFERATION-INDUCER, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND METHOD FOR PRODUCING MYOCARDIAL CELLS
Abstract:
Provided are a myocardial cell proliferation-inducer and a pharmaceutical composition containing any one or more of a polypeptide of (1)-(3) and/or a partial peptide thereof as a novel drug having activity to induce the proliferation of myocardial cells. This pharmaceutical composition can be used suitably in the treatment and/or prevention of heart disease, especially ischemic heart disease. (1) Polypeptide comprising an amino acid sequence of SEQ ID NO: 1. (2) Polypeptide having activity to induce proliferation of myocardial cells, comprising an amino acid sequence in which from one to several amino acids in an amino acid sequence of SEQ ID NO: 1 have been deleted, substituted, inserted, or added. (3) Polypeptide having activity to induce proliferation of myocardial cells, showing 80% or greater sequence identity with an amino acid sequence of SEQ ID NO: 1.