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1. (WO2015044900) THERAPEUTIC IMMUNOMODULATING COMPOUNDS

Pub. No.:    WO/2015/044900    International Application No.:    PCT/IB2014/064851
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Sat Sep 27 01:59:59 CEST 2014
IPC: C07K 14/705
C07K 7/54
C07K 7/50
A61K 38/12
Applicants: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
Inventors: SASIKUMAR, Pottayil, Govindan, Nair
RAMACHANDRA, Muralidhara
NAREMADDEPALLI, Seetharamaiah, Setty, Sudarshan
Title: THERAPEUTIC IMMUNOMODULATING COMPOUNDS
Abstract:
The present invention relates to therapeutic immunomodulating compounds capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also encompasses the use of the said therapeutic compounds and their derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.