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1. (WO2015044836) COMPOSITIONS COMPRISING HETEROGENEOUS POPULATIONS OF RECOMBINANT HUMAN CLOTTING FACTOR XA PROTEINS

Pub. No.:    WO/2015/044836    International Application No.:    PCT/IB2014/064564
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Wed Sep 17 01:59:59 CEST 2014
IPC: C07K 14/745
A61K 38/36
A61P 7/04
Applicants: PFIZER INC.
Inventors: JANKOWSKI, Michael Anthony
JOHNSON, Keith A.
PIACENZA, Wendy Carol
ROUSE, Jason C.
SHAMASHKIN, Michael
SHARPE, Penelope Jane
SWITZER, Mary Beth
WESTON, Stacey B.
Title: COMPOSITIONS COMPRISING HETEROGENEOUS POPULATIONS OF RECOMBINANT HUMAN CLOTTING FACTOR XA PROTEINS
Abstract:
Compositions are provided comprising recombinant variants of the human clotting Factor Xa. Such compositions include a wide variety of isoforms and post-translational modifications of FXa and are useful for treating subjects in need of hemostasis.