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1. WO2015044358 - GLUTAMATE RECEPTOR PHOTOMODULATORS

Publication Number WO/2015/044358
Publication Date 02.04.2015
International Application No. PCT/EP2014/070635
International Filing Date 26.09.2014
IPC
C09B 29/036 2006.1
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
29Monoazo dyes prepared by diazotising and coupling
01characterised by the diazo component
033from diazotised amines containing a heterocyclic ring
036the heterocyclic ring containing only nitrogen as hetero atoms
C09B 29/08 2006.1
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
29Monoazo dyes prepared by diazotising and coupling
06from coupling components containing amino as the only directing group
08Amino benzenes
C09B 29/42 2006.1
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
29Monoazo dyes prepared by diazotising and coupling
34from other coupling components
36from heterocyclic compounds
42containing a six-membered ring with one nitrogen atom as the only ring hetero atom
A61K 31/54 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
C07D 471/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
CPC
C07D 213/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Nitrogen atoms
76to which a second hetero atom is attached
C07D 213/81
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78Carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals
81Amides; Imides
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C09B 29/0048
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
29Monoazo dyes prepared by diazotising and coupling
0025from diazotized amino heterocyclic compounds
0029the heterocyclic ring containing only nitrogen as heteroatom
0048containing a six-membered heterocyclic ring with one nitrogen atom
C09B 29/0815
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES ; , e.g. PIGMENTS; MORDANTS; LAKES
29Monoazo dyes prepared by diazotising and coupling
06from coupling components containing amino as the only directing group
08Amino benzenes
0805free of acid groups
0807characterised by the amino group
0809substituted amino group
0811further substituted alkylamino, alkenylamino, alkynylamino, cycloalkylamino aralkylamino or arylamino
0815substituted by -C(=O)-
Applicants
  • CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS [ES]/[ES]
  • UNIVERSITAT AUTÒNOMA DE BARCELONA [ES]/[ES]
  • FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA (IBEC) [ES]/[ES]
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR]/[FR]
  • INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS [ES]/[ES]
Inventors
  • LLEBARIA SOLDEVILA, Amadeo
  • GOROSTIZA LANGA, Pau
  • GÓMEZ SANTACANA, Xavier
  • PITTOLO, Silvia
  • GIRALDO ARJONILLA, Jesús
  • ROVIRA ALGANS, Xavier
  • GOUDET, Cyril
  • PIN, Jean Philippe
Agents
  • CARBONELL VALLÈS, Enric
Priority Data
13382374.027.09.2013EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) GLUTAMATE RECEPTOR PHOTOMODULATORS
(FR) PHOTOMODULATEURS DU RÉCEPTEUR DU GLUTAMATE
Abstract
(EN) The present invention relates to the discovery of particular aromatic compounds of formula (1), possessing activity as modulators of metabotropic glutamate receptors (mGluR) whose modulatory activity on the receptor may be controlled by irradiation with suitable light resulting in the optical control of receptor biological function, to the use of said compounds as a medicament, and to pharmaceutical compositions comprising said compounds of formula (1).
(FR) La présente invention se rapporte à la découverte de composés aromatiques particuliers de formule (1), possédant une activité en tant que modulateurs des récepteurs métabotropiques du glutamate (mGluR) dont l'activité modulatrice sur le récepteur peut être commandée par irradiation avec une lumière appropriée, ce qui provoque la commande optique de la fonction biologique du récepteur; l'invention se rapporte également à l'utilisation desdits composés comme médicament, et à des compositions pharmaceutiques comprenant lesdits composés de formule (1).
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