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1. (WO2015044190) CONTROLLING TISSUE ENGINEERED HEART VALVE GEOMETRY BY USING PREDEFINED INSERTS DURING CULTURE

Pub. No.:    WO/2015/044190    International Application No.:    PCT/EP2014/070352
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Thu Sep 25 01:59:59 CEST 2014
IPC: A61F 2/24
Applicants: UNIVERSITÄT ZÜRICH
TECHNISCHE UNIVERSITEIT EINDHOVEN
Inventors: SANDERS, Bart
VOSSEN-LOERAKKER, Sandra
DRIESSEN-MOL, Anita
HOERSTRUP, Simon Philipp
BAAIJENS, Franciscus Petrus Thomas
Title: CONTROLLING TISSUE ENGINEERED HEART VALVE GEOMETRY BY USING PREDEFINED INSERTS DURING CULTURE
Abstract:
Various inserts, called shapers and spacers, are provided for controlling tissue engineered heart valve (TEHV) leaflet geometry during culture. These inserts will prevent TEHV leaflet retraction during culture, be able to control the leaflet geometry during culture, enable culturing TEHV leaflets with a larger coaptation area, control the height of the coaptation area, maintain TEHV leaflet curvatures, and/or enable possibilities to culture TEHV leaflets in open configuration.