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1. (WO2015044095) IMIDAZO[1,2-A]PYRIDIN-7-AMINES AS IMAGING TOOLS

Pub. No.:    WO/2015/044095    International Application No.:    PCT/EP2014/070162
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Wed Sep 24 01:59:59 CEST 2014
IPC: C07D 471/04
A61K 31/437
A61K 31/4353
A61P 25/28
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: GOBBI, Luca
KNUST, Henner
KOERNER, Matthias
MURI, Dieter
Title: IMIDAZO[1,2-A]PYRIDIN-7-AMINES AS IMAGING TOOLS
Abstract:
The present invention relates to compounds of general formula (I) wherein R1 is lower alkyl or lower alkyl substituted by halogen; R2, R3 are hydrogen or tritium; or to a pharmaceutically acceptable acid addition salt. The compounds may be used for binding and imaging tau aggregates and related beta-sheet aggregates including besides others beta-amyloid aggregates or alpha-synuclein aggregates.