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1. (WO2015043768) NOTCH 1 SPECIFIC SIRNA MOLECULES

Pub. No.:    WO/2015/043768    International Application No.:    PCT/EP2014/002655
Publication Date: Fri Apr 03 01:59:59 CEST 2015 International Filing Date: Wed Oct 01 01:59:59 CEST 2014
IPC: C12N 15/113
A61K 31/712
A61P 35/00
A61K 9/107
Applicants: SOLUVENTIS GMBH
Inventors: SCHREIBER, Sören
Title: NOTCH 1 SPECIFIC SIRNA MOLECULES
Abstract:
The present invention is related to a nucleic acid molecule comprising a double-stranded structure, wherein the double-stranded structure is formed by a first strand and a second strand, wherein the first strand consist of the following nucleotide sequence 5' acGaGcUgGaCcAcUgGuCdTsdT 3', and the second strand consists of the following nucleotide sequence 5' GAcCaGuGgUcCaGcUcGudTsdT 3', wherein a minor nucleotide indicates that the nucleotide is 2'-F modified and an underlined nucleotide indicates that the nucleotide is 2'-0-methyl modified and wherein dTsdT indicates that at the 3' end a dinucleotide is attached consisting of two dT nucletoides, wherein said two dTs are covalently linked through a phosphorothioate bond.