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1. (WO2015043404) (-)-HUPERZINE-A SALT
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/043404 International Application No.: PCT/CN2014/086721
Publication Date: 02.04.2015 International Filing Date: 17.09.2014
IPC:
C07D 221/22 (2006.01) ,A61K 31/4748 (2006.01) ,A61P 25/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
221
Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/-C07D219/187
02
condensed with carbocyclic rings or ring systems
22
Bridged ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4748
forming part of bridged ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
万邦德制药集团股份有限公司 WEPONDE PHARMACEUTICAL GROUP PLC [CN/CN]; 中国浙江省温岭市 城东街道百丈北路28号 No.28, Baizhang north Rd, Chengdong street Wenling, Zhejiang 317500, CN
Inventors:
赵守明 ZHAO, Shouming; CN
江月华 JIANG, Yuehua; CN
陈安 CHEN, An; CN
庄银枪 ZHUANG, Yinqiang; CN
丁跃庭 DING, Yaoting; CN
谢金生 XIE, Jinsheng; CN
谢蔚华 XIE, Weihua; CN
Agent:
北京华科联合专利事务所(普通合伙) BEIJING HUAKE UNION PATENT OFFICE (GENERAL PARTNERSHIP); 中国北京市 朝阳区农展南路5号京朝大厦1号楼3017房间 Room 3017, Jingchao Building 1 No.5 Nongzhan South Rd, Chaoyang District Beijing 100125, CN
Priority Data:
201310436992.824.09.2013CN
Title (EN) (-)-HUPERZINE-A SALT
(FR) SEL D'(-)-HUPERZINE-A
(ZH) (-)-石杉碱甲盐
Abstract:
(EN) The present invention relates to a salt of (-)-huperzine-a, which is prepared from the reaction of huperzine-a and a corresponding acid. The huperzine-a salt is selected from huperzine-a hydrochloride, hydrobromide, sulfate, phosphate, nitrate, acetate, trifluoroacetate, lactate, citrate, oxalate, maleate, succinate, tartrate, fumarate, mandelate, mesylate, benzene sulfonate, gluconate, ascorbate, acetonate, alanine salt, aspartate, lysinate and arginine salt.
(FR) L'invention concerne un sel d'(-)-huperzine-a, préparé à partir de la réaction de l'huperzine-a avec un acide correspondant. Le sel d'huperzine-a est sélectionné dans le groupe comprenant chlorhydrate, bromhydrate, sulfate, phosphate, nitrate, acétate, trifluoroacétate, lactate, citrate, oxalate, maléate, succinate, tartrate, fumarate, mandélate, mésylate, sulfonate de benzène, gluconate, ascorbate, acétonate, sel d'alanine, aspartate, lysinate et sel d'arginine de l'huperzine-a.
(ZH) 本发明涉及石杉碱甲的盐,所述盐是(-)-石杉碱甲和相应的酸反应制备而成,所述石杉碱甲盐选自石杉碱甲的:盐酸盐、氢溴酸盐、硫酸盐、磷酸盐、硝酸盐、乙酸盐、三氟乙酸盐、乳酸盐、枸橼酸盐、草酸盐、马来酸盐、琥珀酸盐、酒石酸盐、富马酸盐、扁桃酸盐、甲磺酸盐、苯磺酸盐、葡萄糖酸盐、抗坏血酸盐、丙酮酸盐、丙氨酸盐、天冬氨酸盐、赖氨酸盐或精氨酸盐。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)