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1. (WO2015042077) SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/042077    International Application No.:    PCT/US2014/055966
Publication Date: 26.03.2015 International Filing Date: 17.09.2014
IPC:
A61K 31/505 (2006.01), C07D 239/02 (2006.01)
Applicants: CALITOR SCIENCES, LLC [US/US]; 107 S Via El Toro Newbury Park, CA 91320 (US).
SUNSHINE LAKE PHARMA CO., LTD. [CN/CN]; Northern Industrial Area, Songshan Lake Dongguan, Guangdong 523000 (CN)
Inventors: XI, Ning; (US).
WANG, Liang; (CN).
WU, Zuping; (CN).
FENG, Xuejin; (CN).
WU, Yanjun; (CN)
Agent: XI, Ning [US/US]; President Calitor Sciences, LLC 107 S Via El Toro Newbury Park, CA 91320 (US)
Priority Data:
61/983,444 23.04.2014 US
61/880,974 22.09.2013 US
Title (EN) SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
(FR) COMPOSÉS SUBSTITUÉS D'AMINOPYRIMIDINE ET PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukernias and solid tumors, in mammals, especially humans.
(FR)L'invention concerne la préparation et l'utilisation de nouveaux dérivés d'aminopyrimidine comme candidats médicaments sous la forme libre ou sous la forme de sels pharmaceutiquement acceptables et les formulations de ceux-ci pour la modulation d'un trouble ou d'une maladie qui est médié(e) par l'activité des enzymes PI3K. L'invention concerne aussi des compositions pharmaceutiquement acceptables comprenant de tels composés et des procédés d'utilisation des compositions dans le traitement de troubles ou de maladies, comme des troubles de l'immunité et de l'inflammation dans lesquels les enzymes PI3K jouent un rôle dans la fonction des leucocytes, et des troubles hyperprolifératifs associés à l'activité de PI3K, incluant, mais n'y étant pas limités, les leucémies et les tumeurs solides chez les mammifères, spécialement les êtres humains.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)