Processing

Please wait...

Settings

Settings

Goto Application

1. WO2015039670 - A METHOD FOR ESTIMATING PERFUSION INDICES

Publication Number WO/2015/039670
Publication Date 26.03.2015
International Application No. PCT/DK2014/050296
International Filing Date 19.09.2014
IPC
A61B 5/026 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
02Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
026Measuring blood flow
G01R 33/56 2006.01
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques
G01R 33/563 2006.01
GPHYSICS
01MEASURING; TESTING
RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33Arrangements or instruments for measuring magnetic variables
20involving magnetic resonance
44using nuclear magnetic resonance
48NMR imaging systems
54Signal processing systems, e.g. using pulse sequences
56Image enhancement or correction, e.g. subtraction or averaging techniques
563of moving material, e.g. flow-contrast angiography
G06F 17/18 2006.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
FELECTRIC DIGITAL DATA PROCESSING
17Digital computing or data processing equipment or methods, specially adapted for specific functions
10Complex mathematical operations
18for evaluating statistical data
G06T 7/00 2006.01
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
7Image analysis
A61B 6/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
CPC
A61B 2576/026
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
2576Medical imaging apparatus involving image processing or analysis
02specially adapted for a particular organ or body part
026for the brain
A61B 5/0263
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
026Measuring blood flow
0263using NMR
A61B 5/4064
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
40Detecting, measuring or recording for evaluating the nervous system
4058for evaluating the central nervous system
4064Evaluating the brain
A61B 6/032
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
02Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
03Computerised tomographs
032Transmission computed tomography [CT]
A61B 6/037
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
02Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
03Computerised tomographs
037Emission tomography
A61B 6/481
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
48Diagnostic techniques
481involving the use of contrast agents
Applicants
  • AARHUS UNIVERSITET [DK]/[DK]
Inventors
  • MOURIDSEN, Kim
  • HANSEN, Mikkel Bo
  • MIKKELSEN, Irene Klærke
  • BEKKE, Susanne Lise
  • KJØLBY, Birgitte Fuglsang
Agents
  • PLOUGMANN VINGTOFT A/S
Priority Data
13185195.819.09.2013EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A METHOD FOR ESTIMATING PERFUSION INDICES
(FR) PROCÉDÉ D'ESTIMATION D'INDICES DE PERFUSION
Abstract
(EN)
The present invention relates to a method for estimating perfusion indices (PI) in a mammal (200), e.g. a human. Data (DAT, DAT') representative of a contrast agent concentration as a function of time of an injected contrast agent is obtained from a medical imaging system (100). Perfusion indices(PI) are found by applying a parametric model (PM) for capillary transit time distributions as a function of time, and a minorize-maximization (MM) type procedure, such as an expectation-maximization (EM) type procedure, with regularization. The minorize-maximization type procedure has an exact analytical expression for the variance of an observation error of the contrast agent (Cε) in a non-linear observation model for the contrast agent concentration used in the maximization step. Clinical tests performed for 7 patients show improved MTT mapping as compared to singular value decomposition (SVD), and reduced sensitivity to delay.
(FR)
La présente invention concerne un procédé d'estimation d'indices de perfusion (PI) chez un mammifère (200), par exemple un humain. Des données (DAT, DAT') représentant une concentration en agent de contraste en fonction du temps d'un agent de contraste injecté sont obtenues dans un système d'imagerie médicale (100). Des indices de perfusion (PI) sont trouvés par application d'un modèle paramétrique (PM) de distributions du temps de transit capillaire en fonction du temps, et une procédure de type minorisation-maximisation (MM), comme une procédure de type attente-maximisation (EM), avec régularisation. La procédure de type minorisation-maximisation a une expression analytique exacte pour la variance d'une erreur d'observation de l'agent de contraste (Cε) dans un modèle d'observation non linéaire pour la concentration en agent de contraste utilisée dans l'étape de maximisation. Des tests cliniques réalisés pour 7 patients ont présenté un mappage MTT amélioré comparé à une décomposition en valeurs singulières (SVD), et une sensibilité réduite au retard.
Latest bibliographic data on file with the International Bureau