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1. (WO2015039670) A METHOD FOR ESTIMATING PERFUSION INDICES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2015/039670 International Application No.: PCT/DK2014/050296
Publication Date: 26.03.2015 International Filing Date: 19.09.2014
IPC:
A61B 5/026 (2006.01) ,G01R 33/56 (2006.01) ,G01R 33/563 (2006.01) ,G06F 17/18 (2006.01) ,G06T 7/00 (2006.01) ,A61B 6/00 (2006.01) ,A61B 8/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
02
Measuring pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography; Heart catheters for measuring blood pressure
026
Measuring blood flow
G PHYSICS
01
MEASURING; TESTING
R
MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33
Arrangements or instruments for measuring magnetic variables
20
involving magnetic resonance
44
using nuclear magnetic resonance (NMR)
48
NMR imaging systems
54
Signal processing systems, e.g. using pulse sequences
56
Image enhancement or correction, e.g. subtraction or averaging techniques
G PHYSICS
01
MEASURING; TESTING
R
MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
33
Arrangements or instruments for measuring magnetic variables
20
involving magnetic resonance
44
using nuclear magnetic resonance (NMR)
48
NMR imaging systems
54
Signal processing systems, e.g. using pulse sequences
56
Image enhancement or correction, e.g. subtraction or averaging techniques
563
of moving material, e.g. flow-contrast angiography
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
17
Digital computing or data processing equipment or methods, specially adapted for specific functions
10
Complex mathematical operations
18
for evaluating statistical data
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
T
IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
7
Image analysis, e.g. from bit-mapped to non bit-mapped
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
6
Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
8
Diagnosis using ultrasonic, sonic or infrasonic waves
06
Measuring blood flow
Applicants:
AARHUS UNIVERSITET [DK/DK]; Nordre Ringgade 1 DK-8000 Aarhus C, DK
Inventors:
MOURIDSEN, Kim; DK
HANSEN, Mikkel Bo; DK
MIKKELSEN, Irene Klærke; DK
BEKKE, Susanne Lise; DK
KJØLBY, Birgitte Fuglsang; DK
Agent:
PLOUGMANN VINGTOFT A/S; Rued Langgaards Vej 8 2300 Copenhagen S, DK
Priority Data:
13185195.819.09.2013EP
Title (EN) A METHOD FOR ESTIMATING PERFUSION INDICES
(FR) PROCÉDÉ D'ESTIMATION D'INDICES DE PERFUSION
Abstract:
(EN) The present invention relates to a method for estimating perfusion indices (PI) in a mammal (200), e.g. a human. Data (DAT, DAT') representative of a contrast agent concentration as a function of time of an injected contrast agent is obtained from a medical imaging system (100). Perfusion indices(PI) are found by applying a parametric model (PM) for capillary transit time distributions as a function of time, and a minorize-maximization (MM) type procedure, such as an expectation-maximization (EM) type procedure, with regularization. The minorize-maximization type procedure has an exact analytical expression for the variance of an observation error of the contrast agent (Cε) in a non-linear observation model for the contrast agent concentration used in the maximization step. Clinical tests performed for 7 patients show improved MTT mapping as compared to singular value decomposition (SVD), and reduced sensitivity to delay.
(FR) La présente invention concerne un procédé d'estimation d'indices de perfusion (PI) chez un mammifère (200), par exemple un humain. Des données (DAT, DAT') représentant une concentration en agent de contraste en fonction du temps d'un agent de contraste injecté sont obtenues dans un système d'imagerie médicale (100). Des indices de perfusion (PI) sont trouvés par application d'un modèle paramétrique (PM) de distributions du temps de transit capillaire en fonction du temps, et une procédure de type minorisation-maximisation (MM), comme une procédure de type attente-maximisation (EM), avec régularisation. La procédure de type minorisation-maximisation a une expression analytique exacte pour la variance d'une erreur d'observation de l'agent de contraste (Cε) dans un modèle d'observation non linéaire pour la concentration en agent de contraste utilisée dans l'étape de maximisation. Des tests cliniques réalisés pour 7 patients ont présenté un mappage MTT amélioré comparé à une décomposition en valeurs singulières (SVD), et une sensibilité réduite au retard.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP3046464US20160228085JP2016530056