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1. (WO2015039334) TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/039334    International Application No.:    PCT/CN2013/083932
Publication Date: 26.03.2015 International Filing Date: 22.09.2013
IPC:
C07D 311/82 (2006.01), C07C 13/567 (2006.01), A61K 31/352 (2006.01), A61K 31/175 (2006.01), A61P 43/00 (2006.01), A61P 9/10 (2006.01), A61P 9/00 (2006.01), A61P 35/00 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065 (US) (For All Designated States Except US).
COOKE, Andrew J. [GB/US]; (US) (US only).
STUMP, Craig A. [US/US]; (US) (US only).
ZHANG, Xu-Fang [US/US]; (US) (US only).
LI, Chun Sing [CA/CN]; (CN) (US only).
MAO, Qinghua [CN/CN]; (CN) (US only)
Inventors: COOKE, Andrew J.; (US).
STUMP, Craig A.; (US).
ZHANG, Xu-Fang; (US).
LI, Chun Sing; (CN).
MAO, Qinghua; (CN)
Agent: LIU, SHEN & ASSOCIATES; 10th Floor, Building 1, 10 Caihefang Road, Haidian District Beijing 100080 (CN)
Priority Data:
Title (EN) TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
(FR) INHIBITEURS DE LA KINASE TRKA, COMPOSITIONS EN CONTENANT ET PROCÉDÉS CORRESPONDANTS
Abstract: front page image
(EN)The present invention is directed to benzyl urea compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
(FR)La présente invention concerne des composés de benzylurée de formule (I), qui sont des inhibiteurs de protéines kinases de la famille des kinases apparentées à la tropomyosine (Trk) et, par conséquent, qui peuvent être utiles dans le traitement de la douleur, d'une inflammation, d'un cancer, de la resténose, de l'athérosclérose, du psoriasis, d'une thrombose, d'une maladie, d'un trouble, d'une lésion ou d'un dysfonctionnement associés à une dysmyélinisation ou à une démyélinisation ou d'une maladie ou d'un trouble associés à des activités anormales du récepteur TrkA, Trk-B et/ou Trk-C du facteur de croissance nerveuse (NGF).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)