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1. (WO2015038818) LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/038818    International Application No.:    PCT/US2014/055254
Publication Date: 19.03.2015 International Filing Date: 11.09.2014
IPC:
A61K 9/08 (2006.01), A61K 47/20 (2006.01), A61K 39/395 (2006.01), C07K 1/14 (2006.01)
Applicants: ARSIA THERAPEUTICS, INC. [US/US]; 1000 Winter Street Suite 3350 Waltham, Massachusetts 02451 (US)
Inventors: LARSON, Alyssa, M.; (US).
LOVE, Kevin; (US).
WEIGHT, Alisha, K.; (US).
CRANE, Alan; (US).
LANGER, Robert, S.; (US).
KLIBANOV, Alexander, M.; (US)
Agent: TIAN, Zong-Qiang Bill; Morrison & Foerster LLP 755 Page Mill Road Palo Alto, California 94304-1018 (US)
Priority Data:
61/876,621 11.09.2013 US
61/940,227 14.02.2014 US
61/943,197 21.02.2014 US
61/946,436 28.02.2014 US
61/988,005 02.05.2014 US
62/008,050 05.06.2014 US
62/026,497 18.07.2014 US
62/030,521 29.07.2014 US
Title (EN) LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS
(FR) FORMULATIONS DE PROTÉINES LIQUIDES CONTENANT DES AGENTS ABAISSANT LA VISCOSITÉ
Abstract: front page image
(EN)Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-lowering agents that are typically bulky polar organic compounds, such as many of the GRAS (US Food and Drug Administration List of compounds generally regarded as safe) and inactive injectable ingredients and FDA approved therapeutics.
(FR)La présente invention concerne des formulations pharmaceutiques de protéines qui sont liquides, de faible volume, de faible viscosité et concentrées. De telles formulations peuvent être administrées rapidement et de manière pratique par injection sous-cutanée ou intramusculaire, plutôt que par l'intermédiaire d'une perfusion intraveineuse qui dure longtemps. Ces formulations comprennent des protéines de faible poids moléculaire et/ou de poids moléculaire élevé, telles que AcM, et des agents qui abaissent la viscosité qui sont typiquement des composés organiques polaires volumineux, tels qu'un grand nombre des composés GRAS (liste de composés de la US Food and Drug Administration considérés généralement comme inoffensifs), des ingrédients injectables inactifs et des composés thérapeutiques approuvés par la FDA.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)