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1. (WO2015038743) NOVEL ANTHRANILIC AMIDES AND THE USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/038743    International Application No.:    PCT/US2014/055143
Publication Date: 19.03.2015 International Filing Date: 11.09.2014
IPC:
A61K 31/245 (2006.01), C07C 63/06 (2006.01), C07C 69/78 (2006.01), C07C 211/55 (2006.01)
Applicants: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND [US/US]; 1430 Tulane Ave., TB-32 New Orleans, LA 70112-2632 (US).
DUQUESNE UNIVERSITY OF THE HOLY GHOST [US/US]; 505 Administration Building Pittsburgh, PA 15282 (US)
Inventors: CHAKRABARTY, Suravi; (US).
FLAHERTY, Patrick, T.; (US).
MONLISH, Darlene; (US).
CAVANAUGH, Jane, E.; (US).
BUROW, Matthew, E.; (US).
ELLIOTT, Steven; (US).
HOANG, Van, T.; (US)
Agent: GRISWOLD, Ian, J.; (US)
Priority Data:
61/876,645 11.09.2013 US
Title (EN) NOVEL ANTHRANILIC AMIDES AND THE USE THEREOF
(FR) NOUVEAUX AMIDES ANTHRANILIQUES ET UTILISATION DE CES DERNIERS
Abstract: front page image
(EN)Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.
(FR)L'invention concerne de nouveaux dérivés d'amide anthranilique de la formule. L'invention se rapporte à des compositions qui renferment les dérivés d'amide anthranilique précités et à l'utilisation desdits dérivés d'amide anthranilique dans la fabrication d'un médicament. L'invention porte en outre sur des procédés qui permettent d'inhiber ou traiter un cancer, d'inhiber ou inverser une transition cellulaire épithélio-mésenchymateuse et/ou d'inhiber l'activité enzymatique MEKI/2 et/ou MEK 5 chez un sujet en lui administrant une quantité efficace d'un dérivé d'amide anthranilique selon l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)