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1. (WO2015037945) PHARMACEUTICAL COMPOSITION FOR DENTAL PULP REGENERATIVE THERAPY AND APEXIFICATION THERAPY, COMPRISING PROLYL HYDROXYLASE INHIBITOR OR HISTONE DEACETYLASE INHIBITOR, AND ANTIBIOTICS, AND SYNTHETIC POLYMER NANOFIBER MESH COMPRISING COMPOSITION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/037945    International Application No.:    PCT/KR2014/008538
Publication Date: 19.03.2015 International Filing Date: 12.09.2014
IPC:
A61K 31/16 (2006.01), A61K 31/44 (2006.01), A61P 1/02 (2006.01), A61P 19/00 (2006.01)
Applicants: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR/KR]; 1, Gwanak-ro, Gwanak-gu, Seoul 08826 (KR)
Inventors: WOO, Kyung Mi; (KR).
LEE, Woo Cheol; (KR)
Agent: YOU ME PATENT AND LAW FIRM; Seolim Building, 115 Teheran-ro, Gangnam-gu, Seoul 135-912 (KR)
Priority Data:
10-2013-0110139 13.09.2013 KR
10-2014-0121179 12.09.2014 KR
Title (EN) PHARMACEUTICAL COMPOSITION FOR DENTAL PULP REGENERATIVE THERAPY AND APEXIFICATION THERAPY, COMPRISING PROLYL HYDROXYLASE INHIBITOR OR HISTONE DEACETYLASE INHIBITOR, AND ANTIBIOTICS, AND SYNTHETIC POLYMER NANOFIBER MESH COMPRISING COMPOSITION
(FR) COMPOSITION PHARMACEUTIQUE POUR THÉRAPIE DE RÉGÉNÉRATION DE LA PULPE DENTAIRE ET THÉRAPEUTIQUE D'APEXIFICATION COMPRENANT UN INHIBITEUR DE LA PROLYL-HYDROXYLASE OU UN INHIBITEUR DE L'HISTONE DÉSACÉTYLASE ET DES ANTIBIOTIQUES, ET RÉSEAU DE NANOFIBRES DE POLYMÈRES SYNTHÉTIQUES COMPRENANT LA COMPOSITION
(KO) 프롤릴 히드록실라아제 저해제 또는 히스톤 탈아세틸라아제 저해제, 및 항생제를 포함하는 치수 재생 치료 또는 치근첨 형성 유도 치료용 약학적 조성물, 및 이를 포함하는 합성고분자 나노섬유메시
Abstract: front page image
(EN)The present invention relates to a pharmaceutical composition for dental pulp regenerative therapy, comprising: at least one selected from prolyl hydroxylase inhibitor and histone deacetylase inhibitor; and antibiotics. The pharmaceutical composition for dental pulp regenerative therapy and apexification, comprising prolyl hydroxylase inhibitor and/or histone deacetylase inhibitor and antibiotics, and the synthetic polymer nanofiber mesh comprising the composition, of the present application, inhibit and alleviate inflammation caused by bacterial infection and simultaneously induce dental pulp regeneration and formation of root apex through revascularization of dental pulp tissues, and thus can be used for effective dental pulp regenerative therapy and apexification.
(FR)L'invention concerne une composition pharmaceutique pour thérapie de régénération de la pulpe dentaire, qui comprend: au moins un élément choisi parmi un inhibiteur de la prolyl-hydroxylase et un inhibiteur de l'histone désacétylase; et des antibiotiques. Selon l'invention, cette composition pharmaceutique et ce réseau de nanofibres de polymères comprenant la composition inhibent et atténuent une inflammation due à une infection bactérienne et induisent simultanément la régénération de la pulpe dentaire et la formation d'apex de la racine par la revascularisation des tissus du pulpe dentaire, et peuvent donc s'utiliser pour une thérapie efficace de régénération de la pulpe dentaire ou une thérapeutique d'apexification.
(KO)본 발명은 프롤릴 히드록실라아제 저해제 및 히스톤 탈아세틸라아제 저해제 중에서 선택된 1종 이상; 및 항생제를 포함하는 치수 재생 치료용 약학적 조성물에 관한 것이다. 본 발명의 프롤릴 히드록실라아제 저해제 및/또는 히스톤 탈아세틸라아제 저해제, 및 항생제를 포함하는 치수 재생 치료 및 치근첨 형성 유도용 약학적 조성물과 이를 포함하는 합성고분자 나노섬유메시는 세균감염에 의한 염증을 억제 및 완화함과 동시에 치수조직의 혈관 재형성을 통한 치수 재생과 근첨부 형성을 유도하는바, 효과적인 치수 재생 치료 및 치근첨 형성 유도에 이용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)