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1. (WO2015037460) METHOD FOR PRODUCING OPTICALLY ACTIVE 3-(BIPHENYL-4-YL)-2-[(t-BUTOXYCARBONYL)AMINO]PROPAN-1-OL
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2015/037460 International Application No.: PCT/JP2014/072854
Publication Date: 19.03.2015 International Filing Date: 26.08.2014
IPC:
C07C 269/00 (2006.01) ,C07C 233/18 (2006.01) ,C07C 271/16 (2006.01) ,C07B 53/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
269
Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
16
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
17
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
18
having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
271
Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06
Esters of carbamic acids
08
having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10
with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
16
to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
53
Asymmetric syntheses
Applicants:
住友化学株式会社 SUMITOMO CHEMICAL COMPANY, LIMITED [JP/JP]; 東京都中央区新川二丁目27番1号 27-1, Shinkawa 2-chome, Chuo-ku, Tokyo 1048260, JP
Inventors:
友川 淳一 TOMOKAWA, Junichi; JP
秋山 雅紀 AKIYAMA, Masaki; JP
Agent:
中山 亨 NAKAYAMA, Tohru; JP
Priority Data:
2013-18702410.09.2013JP
Title (EN) METHOD FOR PRODUCING OPTICALLY ACTIVE 3-(BIPHENYL-4-YL)-2-[(t-BUTOXYCARBONYL)AMINO]PROPAN-1-OL
(FR) PROCÉDÉ DE PRODUCTION DE 3-(BIPHÉNYLE-4-YL)-2-[(t-BUTOXYCARBONYL)AMINO]PROPAN-1-OL OPTIQUEMENT ACTIF
(JA) 光学活性な3-(ビフェニル-4-イル)-2-[(t-ブトキシカルボニル)アミノ]プロパン-1-オールの製造方法
Abstract:
(EN) Optically active 3-(biphenyl-4-yl)-2-[(t-butoxycarbonyl)amino]propan-1-ol can be produced through: a step of reacting an optically active biphenylalanine compound represented by formula [I] with a reducing agent to produce an optically active biphenylalaninol compound represented by formula [II]; and a step of hydrolyzing the optically active biphenylalaninol compound represented by formula [II], which is produced in the proceeding step, under acidic conditions and then reacting the resultant product with t-butyl dicarbonate to produce optically active 3-(biphenyl-4-yl)-2-[(t-butoxycarbonyl)amino]propan-1-ol represented by formula [III].
(FR) L'invention concerne un procédé de production du 3-(biphényle-4-yl)-2-[(t-butoxycarbonyl)amino]propan-1-ol optiquement actif par une étape de réaction d'un composé biphénylalanine optiquement actif représenté par la formule [I] avec un agent réducteur pour produire un composé biphénylalaninol optiquement actif représenté par la formule [II]; et par une étape d'hydrolyse du composé biphénylalaninol optiquement actif représenté par la formule [II], qui est produit au cours de l'étape précédente, dans des conditions acides, puis de réaction du produit obtenu avec du dicarbonate de tert-butyle pour produire le 3-(biphényle-4-yl)-2-[(t-butoxycarbonyl)amino]propan-1-ol optiquement actif représenté par la formule [III].
(JA)  式[Ⅰ]で示される光学活性なビフェニルアラニンを還元剤と反応させて式[Ⅱ]で示される光学活性な ビフェニルアラニノールを得る工程;並びに、前記工程で得た式[Ⅱ]で示される光学活性なビフェニ ルアラニノールを酸性条件下に加水分解し、次いで生成物を二炭酸‐t‐ブチルと反応させて式[Ⅲ]で 示される光学活性な3-(ビフェニル-4-イル)-2-〔(t-ブトキシカルボニル)アミノ〕プロ パン-1-オールを得る工程により、光学活性な3-(ビフェニル-4-イル)-2-〔(t-ブトキ シカルボニル)アミノ〕プロパン-1-オールを製造することができる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)