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Pub. No.:    WO/2015/036062    International Application No.:    PCT/EP2013/073365
Publication Date: 19.03.2015 International Filing Date: 08.11.2013
A61K 39/21 (2006.01), C07K 14/16 (2006.01)
Applicants: GLAXOSMITHKLINE BIOLOGICALS SA [BE/BE]; rue de l'Institut 89 B-1330 Rixensart (BE)
Inventors: BOURGUIGNON, Patricia B; (BE).
KOUTSOUKOS, Marguerite Christine; (BE).
LORIN, Clarisse Marie-Madeleine; (BE)
Agent: DRURY, Elizabeth; GlaxoSmithKline, Global Patents CN925.1 980 Great West Road Brentford Middlesex TW8 9GS (GB)
Priority Data:
1316464.5 16.09.2013 GB
Abstract: front page image
(EN)The present invention relates to particular immunogenic compositions comprising a gp120 related polypeptide and an adjuvant, wherein the adjuvant comprises a saponin and a lipopolysaccharide. Such compositions are substantially free of a NefTat related polypeptide, comprise between 10-40ug of a lipopolysaccharide and between 10-40ug of an immunologically active saponin fraction derived from the bark of Quillaja Saponaria Molina presented in the form of a liposome or have a concentration of sodium chloride of 130 mM or lower.
(FR)La présente invention concerne des compositions immunogènes particulières comprenant un polypeptide se rapportant à gp120 et un adjuvant, l'adjuvant comprenant une saponine et un lipopolysaccharide. De telles compositions sont essentiellement dépourvues d'un polypeptide se rapportant à NefTat, comprennent entre 10 et 40 µg d'un lipopolysaccharide et entre 10 et 40 µg d'une fraction de saponine immunologiquement active dérivée de l'écorce de Quillaja Saponaria Molina présentée sous la forme d'un liposome ou possèdent une concentration en chlorure de sodium inférieure ou égale à 130 mM.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)