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1. (WO2015035337) HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/035337 International Application No.: PCT/US2014/054617
Publication Date: 12.03.2015 International Filing Date: 08.09.2014
IPC:
A61K 35/14 (2015.01) ,A61K 31/7012 (2006.01) ,A61K 31/739 (2006.01)
Applicants: ACADEMIA SINICA; 128 Academia Road Section 2, Nankang 11529 Taipei, TW
Inventors: WONG, Chi-Huey; US
YU, Alice L.; TW
LIN, Kun-Hsien; TW
WU, Tai-Na; TW
Agent: NORTON, Vicki G.; US
Priority Data:
61/874,94606.09.2013US
Title (EN) HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS
(FR) ACTIVATION DES CELLULES HUMAINES INKT À L'AIDE DE GLYCOLIPIDES AYANT DES GROUPES GLYCOLSYLES MODIFIÉS
Abstract:
(EN) Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.
(FR) L'invention concerne des glycosphingolipides (GSL) portant l'α-glucose (α-Glc) qui stimulent de préférence les cellules NKT humaines invariantes (iNKT). L'invention concerne des GSL avec l'α-glucose (α-Glc) qui montrent une induction, plus forte chez les êtres humains, de cytokines et de chimiokines et une expansion et/ou une activation plus fortes des cellules immunes que celles avec l'α-galactose (α-Gal) (mais plus faibles chez les souris). L'invention concerne des GSL portant l'α-glucose (α-Glc) et les dérivés d'α-Glc avec F aux positions 4 et/ou 6. L'invention concerne des procédés d'induction indépendante de iNKT de chimiokines par le GSL avec l'α-Glc et les dérivés de celui-ci. L'invention concerne des procédés de stimulation immune chez les êtres humains utilisant les GSL avec l'α-Glc et les dérivés de celui-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)