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1. (WO2015035261) SYSTEMS, DEVICES AND METHODS FOR ANTI-TL1A THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/035261    International Application No.:    PCT/US2014/054425
Publication Date: 12.03.2015 International Filing Date: 05.09.2014
IPC:
A61P 37/06 (2006.01)
Applicants: CEDARS-SINAI MEDICAL CENTER [US/US]; 8700 Beverly Boulevard Los Angeles, California 90048 (US)
Inventors: TARGAN, Stephan R.; (US).
GONSKY, Rebecca; (US).
DEEM, Richard; (US)
Agent: SENN, Sean; (US)
Priority Data:
61/874,487 06.09.2013 US
Title (EN) SYSTEMS, DEVICES AND METHODS FOR ANTI-TL1A THERAPY
(FR) SYSTÈMES, DISPOSITIFS ET PROCÉDÉS POUR THÉRAPIE ANTI-TL1A
Abstract: front page image
(EN)The present invention relates to biomarker genes for diagnosing and treating diseases. Provided herein are systems and methods of diagnosing a disease in a patient based on the patient's expression levels of biomarker genes. Examples of the TL1A-associated disease include, but are not limited to, an inflammatory bowel disease (IBD), Crohn's disease (CD), ulcerative colitis (UC), and fibrosis. Also provided herein are systems and methods of identifying a patient likely to be responsive to an anti-TL1A therapy, prescribing and/or administrating an anti-TL1A therapy to the patient based on the patient's expression levels of biomarker genes.
(FR)La présente invention concerne des gènes de biomarqueur utiles dans le diagnostic et le traitement de maladies. L'invention porte plus particulièrement sur des systèmes et des procédés de diagnostic d'une maladie chez un patient, sur la base des niveaux d'expression de gènes de biomarqueur chez ledit patient. Des exemples de maladies associées au TL1A incluent, sans caractère limitatif, la maladie inflammatoire chronique de l'intestin, la maladie de Crohn, la colite ulcéreuse, et la fibrose. L'invention porte en outre sur des systèmes et des procédés d'identification d'un patient susceptible de réagir à une thérapie anti-TL1A, et de prescription et/ou d'administration d'une thérapie anti-TL1A audit patient sur la base des niveaux d'expression de gènes de biomarqueur chez ce patient.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)