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1. (WO2015035117) PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/035117    International Application No.:    PCT/US2014/054209
Publication Date: 12.03.2015 International Filing Date: 05.09.2014
IPC:
A61K 31/519 (2006.01), C07D 487/04 (2006.01), A61P 25/02 (2006.01)
Applicants: LEXICON PHARMACEUTICALS, INC. [US/US]; 8800 Technology Forest Place The Woodlands, TX 77381 (US)
Inventors: BI, Yingzhi; (US).
GARDYAN, Michael Walter; (US).
GREEN, Michael Alan; (US).
KUMI, Godwin; (US).
ZHANG, Yulian; (US)
Agent: BACHRACH, Max; (US)
Priority Data:
61/874,395 06.09.2013 US
Title (EN) PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
(FR) COMPOSÉS À BASE DE PYRAZOLO[1,5-A] PYRIMIDINE, COMPOSITIONS LES COMPRENANT ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)Pyrazolo[1,5-a]pyrimidine-based compounds of the formula (I) are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
(FR)La présente invention concerne des composés à base de pyrazolo[1,5-a] pyrimidine de la formule (I) dans laquelle R1, R2 et R3 sont tels que définis dans la description. L'invention comprend également des compositions comportant les composés et des procédés les utilisant pour traiter, gérer et/ou prévenir des maladies et des troubles médiés par l'activité de la kinase 1 associée à l'adaptateur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)