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1. (WO2015035113) SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/035113    International Application No.:    PCT/US2014/054202
Publication Date: 12.03.2015 International Filing Date: 05.09.2014
IPC:
C07D 471/10 (2006.01), A61K 31/438 (2006.01), A61P 9/00 (2006.01), A61P 1/00 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: KAROS PHARMACEUTICALS, INC. [US/US]; 5 Science Park Suite 2 New Haven, Connecticut 06511 (US)
Inventors: DE LOMBAERT, Stéphane; (US).
GOLDBERG, Daniel R.; (US).
BRAMELD, Kenneth; (US).
SJOGREN, Eric Brian; (US).
SCRIBNER, Andrew; (US)
Agent: GODDARD, Christine, A.; (US)
Priority Data:
61/874,545 06.09.2013 US
61/899,943 05.11.2013 US
62/004,385 29.05.2014 US
Title (EN) SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS
(FR) COMPOSÉS SPIROCYCLIQUES EN TANT QU'INHIBITEURS DE LA TRYPTOPHANE HYDROXYLASE
Abstract: front page image
(EN)The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, and low bone mass diseases, as well as serotonin syndrome, and cancer.
(FR)La présente invention concerne des composés spirocycliques qui sont des inhibiteurs de la tryptophane hydroxylase (TPH), en particulier de son isoforme 1 (TPH1), qui sont utiles pour le traitement de maladies ou de troubles associés à la sérotonine périphérique, comprenant par exemple les maladies gastro-intestinales, cardiovasculaires, pulmonaires, inflammatoires, métaboliques, et les maladies à faible masse osseuse, ainsi que le syndrome sérotoninergique, et le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)