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1. (WO2015035051) METHODS AND COMPOSITIONS FOR SELECTIVE AND TARGETED CANCER THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/035051    International Application No.:    PCT/US2014/054099
Publication Date: 12.03.2015 International Filing Date: 04.09.2014
IPC:
A61K 31/426 (2006.01), A61K 31/428 (2006.01), A61P 35/00 (2006.01)
Applicants: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street Austin, Texas 78701 (US)
Inventors: READY, Joseph M.; (US).
NIJHAWAN, Deepak; (US).
GONZALES, Stephen S.; (US).
THEODOROPOULOS, Pano; (US)
Agent: DYKEMAN, David J.; (US)
Priority Data:
61/873,781 04.09.2013 US
61/938,603 11.02.2014 US
Title (EN) METHODS AND COMPOSITIONS FOR SELECTIVE AND TARGETED CANCER THERAPY
(FR) PROCÉDÉS ET COMPOSITIONS POUR UNE CANCÉROTHÉRAPIE SÉLECTIVE ET CIBLÉE
Abstract: front page image
(EN)Provided herein are methods and compositions for selective and targeted cancer therapy, in particular certain benzothiophenes, benzothiazoles, oxalamides, N-acyl ureas and chromones, and their use in selectively treating certain adenocarcinomas. In some embodiments, the selective toxicity of the compounds may be mediated through SCD1 and/or CYP450 such as CYP4F11.
(FR)La présente invention concerne des procédés et des compositions pour une cancérothérapie sélective et ciblée, en particulier certains benzothiophènes, benzothiazoles, oxalamides, certaines N-acyl-urées et chromones, et leur utilisation dans le traitement sélectif de certains adénocarcinomes. Dans certains modes de réalisation, la toxicité sélective de ces composés peut être médiée par la SCD1 et/ou le cytochrome P450, tel que le CYP4F11.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)