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1. (WO2015035003) THIOETHER PRODRUG COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/035003    International Application No.:    PCT/US2014/054019
Publication Date: 12.03.2015 International Filing Date: 04.09.2014
IPC:
C07C 323/62 (2006.01), A61K 31/166 (2006.01), A61P 31/14 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, Maryland 20892-7660 (US)
Inventors: APPELLA, Daniel; (US).
KUMAR, Pankaj; (US).
SHANK, Nathaniel; (US).
HASSINK, Matthew David; (US)
Agent: PILLAI, Xavier; (US)
Priority Data:
61/874,182 05.09.2013 US
Title (EN) THIOETHER PRODRUG COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS
(FR) COMPOSITIONS DE PROMÉDICAMENT THIOÉTHER UTILISÉES COMME AGENTS ANTI-VIH ET ANTIRÉTROVIRAUX
Abstract: front page image
(EN)Disclosed are inhibitors of retroviral growth of formula (I), that are useful in treatment of retroviral infections such as HIV. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one compound or salt of the invention, a method for inactivating a virus, a method for dissociating a metal ion from a zinc finger-containing protein method, and a method for inhibiting the transmission of a virus, wherein R is hydrogen or a linear or branched alkyl.
(FR)L'invention porte sur des inhibiteurs de croissance rétrovirale de formule (I), qui sont utiles en traitement d'infections rétrovirales telles que des infections à VIH. L'invention porte également sur une composition comprenant un vecteur pharmaceutiquement acceptable et au moins un composé ou sel selon l'invention, sur un procédé d'inactivation d'un virus, sur un procédé pour la dissociation d'un ion métallique d'une protéine contenant un doigt à zinc et sur un procédé d'inhibition de la transmission d'un virus. Dans la formule, R représente l'atome d'hydrogène ou groupe alkyle linéaire ou ramifié.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)