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1. (WO2015033565) USE OF RHOA IN CANCER DIAGNOSIS AND INHIBITOR SCREENING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/033565    International Application No.:    PCT/JP2014/004539
Publication Date: 12.03.2015 International Filing Date: 04.09.2014
IPC:
C12N 15/09 (2006.01), A61K 31/7088 (2006.01), A61K 48/00 (2006.01), A61P 35/00 (2006.01), C07K 14/705 (2006.01), C12N 1/15 (2006.01), C12N 1/19 (2006.01), C12N 1/21 (2006.01), C12N 5/10 (2006.01), C12Q 1/02 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: THE UNIVERSITY OF TOKYO [JP/JP]; 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654 (JP).
CHUGAI SEIYAKU KABUSHIKI KAISHA [JP/JP]; 5-1, Ukima 5-chome, Kita-ku, Tokyo 1158543 (JP)
Inventors: ABURATANI, Hiroyuki; (JP).
ISHIKAWA, Shumpei; (JP).
KAKIUCHI, Miwako; (JP).
NISHIZAWA, Takashi; (JP)
Agent: OHNO, Seiji; (JP)
Priority Data:
2013-185493 06.09.2013 JP
Title (EN) USE OF RHOA IN CANCER DIAGNOSIS AND INHIBITOR SCREENING
(FR) UTILISATION DE RHOA DANS LE DIAGNOSTIC DU CANCER ET CRIBLAGE D'INHIBITEUR
(JA) 癌の診断、阻害剤のスクリーニングにおけるRHOAの使用
Abstract: front page image
(EN)Disclosed are a novel cancer detection method, a screening method for an inhibitor and anti-cancer drug targeting a molecule related to cancer, and a cancer treatment agent, and specifically, a mutated RHOA polypeptide, a polynucleotide for coding said polypeptide, and a method for detecting cancer by using the polypeptide and polynucleotide. In addition, the following are also disclosed: a vector and host cell containing said polynucleotide; a screening method for a cancer treatment agent containing said polypeptide and/or said polynucleotide; and a cancer treatment agent containing an siRNA having an RHOA mutant silencing effect.
(FR)L'invention concerne un nouveau procédé de détection du cancer, un procédé de criblage d'un inhibiteur et un médicament anticancéreux ciblant une molécule liée au cancer, ainsi qu'un agent de traitement contre le cancer et, plus précisément, un polypeptide RHOA qui a muté, un polynucléotide pour coder ledit polypeptide, et un procédé de détection du cancer utilisant le polypeptide et le polynucléotide. L'invention concerne également les éléments suivants : un vecteur et une cellule hôte contenant ledit polynucléotide; un procédé de criblage d'un agent de traitement contre le cancer contenant ledit polypeptide et/ou ledit polynucléotide; et un agent de traitement contre le cancer contenant un ARNsi ayant un effet d'extinction de mutant RHOA.
(JA) 新たな癌の検出方法、癌に関連する分子を標的とした阻害剤や抗癌剤のスクリーニング方法、ならびに癌治療剤として、変異を含むRHOAポリペプチド、当該ポリペプチドをコードするポリヌクレオチド、およびこれらを用いて癌を検出する方法が開示される。また、当該ポリヌクレオチドを含むベクターおよび宿主細胞、当該ポリペプチドおよび/または当該ポリヌクレオチドを含む癌の治療剤のスクリーニング方法、ならびにRHOA変異体のサイレンシング効果を有するsiRNAを含む癌治療剤も開示される。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)