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1. (WO2015033345) SEMAPHORIN 3C VARIANTS, COMPOSITIONS COMPRISING SAID VARIANTS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/033345    International Application No.:    PCT/IL2014/050797
Publication Date: 12.03.2015 International Filing Date: 07.09.2014
IPC:
C07K 14/47 (2006.01), A61K 38/17 (2006.01)
Applicants: RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES [IL/IL]; P.O Box 9697 31096 Haifa (IL)
Inventors: NEUFELD, Gera; (IL).
MUMBLAT, Yelena; (IL).
KESSLER, Ofra; (IL)
Agent: PEARL COHEN ZEDEK LATZER BARATZ; P.O Box 12704 4673339 Herzlia (IL)
Priority Data:
61/875,060 08.09.2013 US
Title (EN) SEMAPHORIN 3C VARIANTS, COMPOSITIONS COMPRISING SAID VARIANTS AND METHODS OF USE THEREOF
(FR) VARIANTS DE LA SÉMAPHORINE 3C, COMPOSITIONS CONTENANT LESDITS VARIANTS ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)The present invention relates, according to some embodiments, to variants of Semaphorin 3C (Sema3C) having amino acid modifications at furin-like pro-protein convertase cleavage sites, rendering these sites resistant to cleavage. The invention further provides, according to certain embodiments, compositions comprising the Sema3C variants, and methods of using the compositions for suppressing the growth of tumors and/or inhibiting the development of tumor metastases.
(FR)La présente invention concerne, selon divers modes de réalisation, des variants de la sémaphorine 3C (Sema3C) présentant des modification d'acides aminés au niveau des sites de clivage de la pro-protéine convertase semblable à la furine, ce qui rend ces sites résistants au clivage. L'invention concerne, en outre, selon certains modes de réalisation, des compositions contenant des variants de la Sema3C et des procédés d'utilisation desdites compositions pour inhiber le développement des tumeurs et/ou des métastases tumorales.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)