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1. (WO2015033299) 1,2,4-OXADIAZOLE DERIVATIVES AS IMMUNOMODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/033299    International Application No.:    PCT/IB2014/064279
Publication Date: 12.03.2015 International Filing Date: 05.09.2014
IPC:
C07D 271/06 (2006.01), C07D 285/08 (2006.01), A61K 31/4245 (2006.01), A61K 31/433 (2006.01)
Applicants: AURIGENE DISCOVERY TECHNOLOGIES LIMITED [IN/IN]; 39-40, KIADB Industrial Area Electronic City Phase II, Hosur Road Bangalore 560 100 Karnataka (IN)
Inventors: SASIKUMAR, Pottayil Govindan Nair; (IN).
RAMACHANDRA, Muralidhara; (IN).
NAREMADDEPALLI, Seetharamaiah Setty Sudarshan; (IN)
Priority Data:
4011/CHE/2013 06.09.2013 IN
Title (EN) 1,2,4-OXADIAZOLE DERIVATIVES AS IMMUNOMODULATORS
(FR) DÉRIVÉS 1,2,4-OXADIAZOLE UTILISÉS COMME IMMUNOMODULATEURS
Abstract: front page image
(EN)The present invention relates to 1,2,4-oxadiazole and 1,2,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signaling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and 5 derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.
(FR)La présente invention concerne des composés 1,2,4-et 1,2,4-thiadiazole utilisés comme agents thérapeutiques aptes à inhiber la voie de signalisation de la mort cellulaire programmée 1 (PD1). L'invention concerne également des dérivés desdits agents thérapeutiques. L'invention concerne aussi l'utilisation desdits agents thérapeutiques et dérivés pour un traitement de troubles par immunopotentialisation comprenant l'inhibition du signal immunosuppresseur induit par PD-1, PD-L1 ou PD-L2, ainsi que des thérapies les utilisant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)