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Machine translation
1. (WO2015032414) METHODS AND TOOLS FOR PREDICTING LIVER FIBROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/032414    International Application No.:    PCT/DK2014/050274
Publication Date: 12.03.2015 International Filing Date: 05.09.2014
IPC:
G01N 33/68 (2006.01)
Applicants: AARHUS UNIVERSITET [DK/DK]; Nordre Ringgade 1 DK-8000 Aarhus C (DK).
REGION MIDTJYLLAND [DK/DK]; Skottenborg 26 DK-8800 Viborg (DK).
THE UNIVERSITY OF SYDNEY [AU/AU]; Parramatta Road New South Wales 2006 Sydney (AU).
WESTMEAD HOSPITAL [AU/AU]; Western Sydney Local Health District CNR Hawkesbury and Darcy Roads Westmead NW 2145 (AU)
Inventors: GRØNBÆK, Henning; (DK).
KAZANKOV, Konstantin; (DK).
MØLLER, Holger Jon; (DK).
BIBBY, Bo Martin; (DK).
GEORGE, Jacob; (AU)
Agent: HØIBERG A/S; St. Kongensgade 59 A DK-1264 Copenhagen K (DK)
Priority Data:
PA 2013 00503 05.09.2013 DK
PA 2014 00043 23.01.2014 DK
Title (EN) METHODS AND TOOLS FOR PREDICTING LIVER FIBROSIS
(FR) PROCÉDÉ ET OUTILS POUR PRÉDIRE LA FIBROSE HÉPATIQUE
Abstract: front page image
(EN)The present application relates to methods and tools for assessing disease progression of liver fibrosis. The methods are based on the demonstration that sCD163 levels correlate significantly with Scheuer fibrosis scores, and that consequently the use of sCD163 serum level can be used to improve existing fibrosis diagnostic scores. In other aspects there is provided novel non-invasive fibrosis scores based on assessment of a few easily detectable markers, including sCD163, age, AST, platelets and optionally fasting insulin and fasting glucose.
(FR)La présente invention concerne des procédés et des outils visant à évaluer la progression de la fibrose hépatique. Les procédés sont basés sur la démonstration selon laquelle des niveaux de sCD163 sont mis en corrélation de manière significative avec des scores de Scheuer de la fibrose, et que, en conséquence, le taux sérique de sCD163 peut être utilisé pour améliorer des scores diagnostiques existants de la fibrose. Selon d'autres aspects, de nouveaux scores non invasifs de fibrose sont basés sur l'évaluation de quelques marqueurs facilement détectables, tels que sCD163, l'âge, l'AST, les plaquettes et éventuellement l'insuline à jeun et le glucose à jeun.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)