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1. (WO2015031771) ADMINISTRATION OF KYNURENINE DEPLETING ENZYMES FOR TUMOR THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/031771    International Application No.:    PCT/US2014/053437
Publication Date: 05.03.2015 International Filing Date: 29.08.2014
IPC:
A61K 38/00 (2006.01), A61K 38/16 (2006.01), A61K 48/00 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 W. 7th Street Austin, TX 78701 (US)
Inventors: GEORGIOU, George; (US).
STONE, Everett; (US)
Agent: JOYNER, Amanda, S.; (US)
Priority Data:
61/872,132 30.08.2013 US
61/986,366 30.04.2014 US
Title (EN) ADMINISTRATION OF KYNURENINE DEPLETING ENZYMES FOR TUMOR THERAPY
(FR) ADMINISTRATION D'ENZYMES DE DÉPLÉTION DE KYNURÉNINE POUR LE TRAITEMENT D'UNE TUMEUR
Abstract: front page image
(EN)Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
(FR)La présente invention concerne des méthodes et des compositions associées à l'utilisation d'une protéine avec l'activité de la kynuréninase. Par exemple, dans certains aspects, l'invention porte sur une kynuréninase modifiée capable de dégrader la kynurénine. En outre, dans certains aspects, l'invention porte sur des compositions et des méthodes de traitement du cancer par déplétion de la kynurénine au moyen des protéines ou des acides nucléiques de la présente invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)