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1. (WO2015031735) ENGINEERED PRIMATE CYSTINE/CYSTEINE DEGRADING ENZYMES AS ANTINEOGENIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/031735    International Application No.:    PCT/US2014/053374
Publication Date: 05.03.2015 International Filing Date: 29.08.2014
IPC:
C12N 9/88 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 W. 7th Street Austin, TX 78701 (US)
Inventors: GEORGIOU, George; (US).
STONE, Everett; (US)
Agent: JOYNER, Amanda, S.; (US)
Priority Data:
61/871,727 29.08.2013 US
61/948,106 05.03.2014 US
Title (EN) ENGINEERED PRIMATE CYSTINE/CYSTEINE DEGRADING ENZYMES AS ANTINEOGENIC AGENTS
(FR) ENZYMES DE DÉGRADATION DE LA CYSTINE/CYSTÉINE MODIFIÉES CHEZ LE PRIMATE À TITRE D'AGENTS ANTI-NÉOGÉNIQUES
Abstract: front page image
(EN)Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-y-lyase comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with L-cyst(e)ine using the disclosed proteins or nucleic acids.
(FR)L'invention concerne des procédés et des compositions portant sur la modification d'une protéine ayant l'activité d'une enzyme de dégradation de la L-cyst(é)ine. Par exemple, selon certains aspects, l'invention peut concerner une cystathionine-y-lyase modifiée comprenant une ou plusieurs substitutions d'acides aminés et capable de dégrader la L-cyst(é)ine. De plus, selon certains aspects, l'invention concerne des compositions et des méthodes destinées à traiter le cancer à l'aide de la L-cyst(é)ine faisant appel aux protéines ou aux acides nucléiques ci-décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)