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1. (WO2015031562) PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/031562    International Application No.:    PCT/US2014/053054
Publication Date: 05.03.2015 International Filing Date: 28.08.2014
IPC:
C07D 231/16 (2006.01), C07D 403/04 (2006.01), C07D 471/14 (2006.01), C07D 207/42 (2006.01), A61K 31/437 (2006.01), A61P 35/00 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, NJ 08543 (US)
Inventors: EASTGATE, Martin, D.; (US).
BEUTNER, Gregory, L.; (US).
COHEN, Benjamin; (US).
CUNIERE, Nicolas; (US).
DESAI, Lopa, V.; (US).
FITZGERALD, Monica; (US).
GAO, Qi; (US).
HAY, Michael, Bryan; (US).
LAWLER, Michael, Joseph; (US).
LOBBEN, Paul, C.; (US).
REGENS, Christopher, S.; (US).
ROSNER, Thorsten; (US).
STROTMAN, Neil; (US).
WEI, Carolyn, S.; (US).
XIAO, Yi; (US).
ZHENG, Bin; (US).
ZHU, Keming; (US)
Agent: KORSEN, Elliott; (US)
Priority Data:
61/871,510 29.08.2013 US
Title (EN) PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE
(FR) PROCÉDÉ DE PRÉPARATION DU N,N-DICYCLOPROPYL-4-(1,5-DIMÉTHYL-1H-PYRAZOL-3YLAMINO)-6-ÉTHYL-1-MÉTHYL-1,6-DIHYDROIMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDINE-7-CARBOXAMIDE
Abstract: front page image
(EN)The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.
(FR)Cette invention concerne un procédé amélioré de synthèse du N,N-dicyclopropyl-4-(1,5-diméthyl-1H-pyrazol-3-ylamino)-6-éthyl-1-méthyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide de formule : (I), ledit Composé (I) étant actuellement en essais cliniques pour le traitement des troubles myéloprolifératifs, tels que la maladie de Vaquez, la thrombocytémie et la myélofibrose primaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)