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1. (WO2015031221) 2,2-DIFLUORODIOXOLO A2A RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/031221    International Application No.:    PCT/US2014/052442
Publication Date: 05.03.2015 International Filing Date: 25.08.2014
IPC:
A01N 43/58 (2006.01), A01N 43/60 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US).
ALI, Amjad [US/US]; (US) (US only).
GALLO, Gioconda, V. [US/US]; (US) (US only).
HENDERSON, Timothy, J. [US/US]; (US) (US only).
KUANG, Rongze [US/US]; (US) (US only).
LIM, Yeon-Hee [US/US]; (US) (US only).
LO, Michael Man-Chu [US/US]; (US) (US only).
METZGER, Edward [US/US]; (US) (US only).
RUIZ, Manuel de Lera [US/US]; (US) (US only).
STAMFORD, Andrew [AU/US]; (US) (US only).
TEMPEST, Paul [US/CN]; (CN) (US only).
WHITEHEAD, Brent [US/US]; (US) (US only).
WU, Heping [US/US]; (US) (US only)
Inventors: ALI, Amjad; (US).
GALLO, Gioconda, V.; (US).
HENDERSON, Timothy, J.; (US).
KUANG, Rongze; (US).
LIM, Yeon-Hee; (US).
LO, Michael Man-Chu; (US).
METZGER, Edward; (US).
RUIZ, Manuel de Lera; (US).
STAMFORD, Andrew; (US).
TEMPEST, Paul; (CN).
WHITEHEAD, Brent; (US).
WU, Heping; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
PCT/CN2013/082560 29.08.2013 CN
Title (EN) 2,2-DIFLUORODIOXOLO A2A RECEPTOR ANTAGONISTS
(FR) 2,2-DIFLUORODIOXOLO ANTAGONISTES DE RÉCEPTEURS A2A
Abstract: front page image
(EN)The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A2A receptor. The present invention is also directed to uses of the 2,2- difluorodioxolo compounds described herein in the potential treatment or prevention of 5 neurological disorders and diseases in which A2A receptor are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds and to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which A2A receptors are involved.
(FR)La présente invention concerne des composés 2,2-difluorodioxolo qui sont des antagonistes du récepteur A2A. La présente invention concerne également des utilisations desdits composés 2,2- difluorodioxolo dans le traitement potentiel ou la prévention de troubles et de maladies neurologiques dans lesquels les récepteurs A sont impliqués. L'invention porte aussi sur des compositions pharmaceutiques comprenant lesdits composés, ainsi que sur des utilisations desdites compositions pharmaceutiques dans la prévention ou le traitement de telles maladies dans lesquelles les récepteurs A2A sont impliqués.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)