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1. (WO2015030711) NEW USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/030711    International Application No.:    PCT/US2013/056680
Publication Date: 05.03.2015 International Filing Date: 26.08.2013
IPC:
A61K 45/06 (2006.01), A61K 31/194 (2006.01), A61K 31/197 (2006.01), A61K 31/216 (2006.01), A61P 9/12 (2006.01), A61P 9/10 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
BRANSFORD, Toni Lynne [US/US]; (US) (US only).
BURKEY, Bryan [US/US]; (US) (US only).
LANGENICKEL, Thomas [CH/DE]; (DE) (US only).
LEFKOWITZ, Martin [US/US]; (US) (US only).
SHI, Victor Chengwei [US/US]; (US) (US only)
Inventors: BRANSFORD, Toni Lynne; (US).
BURKEY, Bryan; (US).
LANGENICKEL, Thomas; (DE).
LEFKOWITZ, Martin; (US).
SHI, Victor Chengwei; (US)
Agent: FISCHER, Leslie; Novartis Pharmaceuticals Corporation Patent Department, Bldg. 101 One Health Plaza East Hanover, New Jersey 07936-1080 (US)
Priority Data:
Title (EN) NEW USE
(FR) NOUVELLE UTILISATION
Abstract: front page image
(EN)The present invention relates to methods and pharmaceutical compositions for renal protection in a mammal in need thereof, such as a mammal having a disease manifested by atrial enlargement and/or remodeling or suffering from hypertension or heart failure or being prone to suffering from hypertension and/or heart failure, comprising administration of a therapeutically effective amount, or a prophylactically effective amount, of an Angiotensin Receptor Neprilysin inhibitor (ARNi) or of a combination of an Angiotensin Receptor Blocker (ARB) with a Neutral Endopeptidase inhibitor (NEPi) or with a NEPi pro-drug to said mammal.
(FR)La présente invention concerne des procédés et des compositions pharmaceutiques pour la protection rénale chez un mammifère dans le besoin de celle-ci, comme un mammifère ayant une maladie qui se manifeste par un élargissement atrial et/ou un remodelage ou souffrant d'hypertension ou d'insuffisance cardiaque ou étant sujet à souffrir d'hypertension et/ou d'insuffisance cardiaque, comprenant l'administration d'une quantité efficace au niveau thérapeutique, ou d'une quantité efficace au niveau prophylactique, d'un inhibiteur de Néprilysine récepteur de l'angiotensine (ARNi) ou d'une combinaison d'un bloqueur du récepteur de l'angiotensine (ARB) avec un inhibiteur d'endopeptidase neutre (NEPi) ou avec un promédicament de NEPi audit mammifère.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)