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1. (WO2015029035) SELECTIVE INHIBITORS OF α2 ISOFORM OF Na,K-ATPase AND USE FOR REDUCTION OF INTRA-OCULAR PRESSURE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/029035    International Application No.:    PCT/IL2014/050773
Publication Date: 05.03.2015 International Filing Date: 27.08.2014
IPC:
C07J 19/00 (2006.01), A61K 31/704 (2006.01), A61K 31/395 (2006.01), A61P 27/06 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; at the Weizmann Institute of Science P.O. Box 95 7610002 Rehovot (IL)
Inventors: KARLISH, Steven J.D.; (IL).
KATZ, Adriana; (IL).
TAL, Daniel M.; (IL)
Agent: EHRLICH, Gal; G.E. Ehrlich (1995) Ltd. 11 Menachem Begin Road 5268104 Ramat Gan (IL)
Priority Data:
61/871,328 29.08.2013 US
Title (EN) SELECTIVE INHIBITORS OF α2 ISOFORM OF Na,K-ATPase AND USE FOR REDUCTION OF INTRA-OCULAR PRESSURE
(FR) INHIBITEURS SÉLECTIFS DE L'ISOFORME Α2 DE LA NA,K-ATPASE ET LEUR UTILISATION POUR RÉDUIRE LA PRESSION INTRA-OCULAIRE
Abstract: front page image
(EN)The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the α2 isoform of Na,K-ATPase, and that reduce intra-ocular pressure. The invention further relates to uses of these derivatives for treating disorders associated with elevated intraocular pressure, such as glaucomas, and/or as cardiotonic agents.
(FR)Cette invention concerne des dérivés de digoxine et de digitoxine qui sont des inhibiteurs sélectifs de l'isoforme α2 de la Na,K-ATPase, et qui réduisent la pression intra-oculaire. L'invention concerne en outre les utilisations de ces dérivés pour traiter des troubles associés à une pression intra-oculaire élevée, tels que les glaucomes, et/ou à titre d'agents cardiotoniques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)