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1. (WO2015027895) NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/027895    International Application No.:    PCT/CN2014/085170
Publication Date: 05.03.2015 International Filing Date: 26.08.2014
IPC:
A61K 48/00 (2006.01), C12N 15/11 (2006.01), A61P 19/10 (2006.01), A61P 19/08 (2006.01)
Applicants: SUZHOU RIBO LIFE SCIENCE CO., LTD. [CN/CN]; No.168 Yuanfeng Road, Yushan Town Kunshan, Jiangsu 215300 (CN)
Inventors: ZHANG, Ge; (CN).
LV, Aiping; (CN).
GUO, Baosheng; (CN).
ZHANG, Hongyan; (CN)
Agent: RUNPING & PARTNERS; Suite 515, Yingu Mansion, No.9 Beisihuanxilu, Haidian District Beijing 100190 (CN)
Priority Data:
201310375603.5 26.08.2013 CN
Title (EN) NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND USES THEREOF
(FR) ACIDE NUCLÉIQUE, COMPOSITION PHARMACEUTIQUE ET UTILISATIONS ASSOCIÉES
(ZH) 一种核酸和药物组合物及其应用
Abstract: front page image
(EN)Provided are a small interfering nucleic acid against CKIP-1 gene inhibiting bone formation, pharmaceutical composition thereof and uses thereof in preparing pharmaceutical composition for treating and/or preventing diseases related to the abnormal expression of CKIP-1 gene. The small interfering nucleic acid is capable of cross-species inhibiting CKIP-1 gene expression, inhibiting CKIP-1 expression in human, rhesus monkey, rat and mice simultaneously, and facilitating the differentiation of osteoblasts and the mineralization of bone matrix effectively.
(FR)La présente invention concerne un petit acide nucléique interférent dirigé contre le gène CKIP-1 inhibant la formation osseuse, une composition pharmaceutique le comprenant et les utilisations associées dans la préparation d’une composition pharmaceutique pour le traitement et/ou la prévention de maladies liées à une expression anormale du gène CKIP-1. Le petit acide nucléique interférent est capable d’inhibition inter-espèce de l’expression du gène CKIP-1, de l’inhibition de l’expression de CKIP-1 chez les humains, les singes rhésus, les rats et les souris simultanément, et facilite la différenciation des ostéoblastes et la minéralisation de la matrice osseuse efficacement.
(ZH)提供了一种针对骨形成抑制基因CKIP-1的小干扰核酸、其药物组合物及其在制备用于治疗和/或预防与CKIP-1基因表达异常相关的疾病的药物组合物中的应用。所述小干扰核酸能够跨物种抑制CKIP-1基因的表达,同时抑制人、恒河猴、大鼠和小鼠CKIP-1的表达,有效促进成骨细胞分化和骨基质矿化。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)