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1. (WO2015027669) PHENYL-SUBSTITUTED COMPOUND, PHARMACEUTICAL COMPOSITION AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/027669    International Application No.:    PCT/CN2014/000808
Publication Date: 05.03.2015 International Filing Date: 29.08.2014
IPC:
C07C 39/08 (2006.01), C07C 47/565 (2006.01), C07C 65/05 (2006.01), C07C 65/21 (2006.01), C07C 65/30 (2006.01), C07C 69/76 (2006.01), C07C 69/88 (2006.01), A61K 31/05 (2006.01), A61K 31/11 (2006.01), A61K 31/192 (2006.01), A61K 31/235 (2006.01), A61P 35/00 (2006.01)
Applicants: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY [CN/CN]; Clear Water Bay, Kowloon Hong Kong (CN)
Inventors: HE, Xiaoqiong; (CN).
TSIM, Karl Wah Keung; (CN).
HUANG, Jack; (US)
Agent: INSIGHT INTELLECTUAL PROPERTY LIMITED; Suite 19A Tower A, InDo Building No. 48A Zhichun Road, Haidian District Beijing 100098 (CN)
Priority Data:
201310390817.X 30.08.2013 CN
Title (EN) PHENYL-SUBSTITUTED COMPOUND, PHARMACEUTICAL COMPOSITION AND USES THEREOF
(FR) COMPOSÉ À SUBSTITUTION PHÉNYLE, COMPOSITION PHARMACEUTIQUE ET LEURS UTILISATIONS
(ZH) 苯基取代化合物及其药物组合物和应用
Abstract: front page image
(EN)Disclosed are a phenyl-substituted compound with structures represented by formula (1) and formula (2), a pharmaceutical composition and uses thereof. The compound can remarkably show in vivo and in vitro that the compound can kill and/or inhibit multiple kinds of tumor cells of human beings and animals, can remarkably accelerate apoptosis and necrosis of the tumor cells, regulate growth cycles of the tumor cells, and inhibit proliferation of the tumor cells. In a same dosage, a cell toxic effect of the compound to normal cells of human bodies is remarkably lower than a cell toxic effect to tumor cells of human beings. The combined use of the compound and a clinical antitumor drug has a remarkable coordinated antitumor effect. The compound and a pharmaceutically acceptable salt thereof can be used for preparing antitumor drugs, antitumor pharmaceutical compositions, combined antitumor pharmaceutical compositions, or auxiliary antitumor health care products.
(FR)L'invention concerne un composé à substitution phényle comprenant des structures représentées par la formule (1) et la formule (2), une composition pharmaceutique et leurs utilisations. Ce composé peut montrer de manière remarquable in vivo et in vitro qu'il peut tuer et/ou inhiber plusieurs types de cellules tumorales chez l'homme et l'animal, peut de manière remarquable accélérer l'apoptose et la nécrose des cellules tumorales, réguler les cycles de croissance des cellules tumorales, et inhiber la prolifération des cellules tumorales. Dans un même dosage, ce composé présente un effet toxique remarquablement inférieur sur les cellules normales du corps humain que sur les cellules tumorales de l'homme. L'utilisation combinée du composé et d'un médicament antitumoral clinique présente un effet antitumoral coordonné remarquable. Ce composé et un sel pharmaceutiquement acceptable de celui-ci peuvent être utilisés pour la préparation de médicaments antitumoraux, de compositions pharmaceutiques antitumorales, de compositions pharmaceutiques antitumorales combinées, ou de produits de santé antitumoraux auxiliaires.
(ZH)本发明公开了具有式(1)和式(2)结构的苯基取代化合物及其药用组合物和应用。该化合物在体内和体外均能显著性杀灭和/或抑制人类和动物的多种肿瘤细胞,能显著性促进癌细胞凋亡和坏死、调节癌细胞生长周期、抑制癌细胞增殖。在同等剂量下,该化合物对人体正常细胞的细胞毒性作用显著性低于对人类肿瘤细胞的细胞毒作用。该化合物与临床抗肿瘤药物联用具有显著性协同抗肿瘤作用。该化合物或其药学上可接受的盐可应用于制备抗肿瘤的药物、抗肿瘤药物组合物、联合抗肿瘤药物组合物或辅助抗肿瘤保健品。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)