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Pub. No.:    WO/2015/027431    International Application No.:    PCT/CN2013/082560
Publication Date: 05.03.2015 International Filing Date: 29.08.2013
C07D 487/14 (2006.01), C07D 487/04 (2006.01), A61K 31/517 (2006.01), A61K 31/505 (2006.01), A61K 31/41 (2006.01), A61K 31/52 (2006.01), A61K 31/55 (2006.01), A61K 31/53 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065 (US) (For All Designated States Except US).
ALI, Amjad [US/US]; (US) (US only).
GALLO, Gioconda V. [US/US]; (US) (US only).
HENDERSON, Timothy J. [US/US]; (US) (US only).
KUANG, Rongze [US/US]; (US) (US only).
LIM, Yeon-Hee [KR/US]; (US) (US only).
LO, Michael Man-Chu [US/US]; (US) (US only).
METZGER, Edward [US/US]; (US) (US only).
RUIZ, Manuel de Lera [ES/US]; (US) (US only).
STAMFORD, Andrew [AU/US]; (US) (US only).
TEMPEST, Paul [US/CN]; (CN) (US only).
WHITEHEAD, Brent [US/US]; (US) (US only).
WU, Heping [US/US]; (US) (US only)
Inventors: ALI, Amjad; (US).
GALLO, Gioconda V.; (US).
HENDERSON, Timothy J.; (US).
KUANG, Rongze; (US).
LIM, Yeon-Hee; (US).
LO, Michael Man-Chu; (US).
METZGER, Edward; (US).
RUIZ, Manuel de Lera; (US).
STAMFORD, Andrew; (US).
TEMPEST, Paul; (CN).
WU, Heping; (US)
Agent: LIU, SHEN & ASSOCIATES; 10th Floor, Building 1, 10 Caihefang Road, Haidian District Beijing 100080 (CN)
Priority Data:
Abstract: front page image
(EN)The present invention is directed to 2,2-difluorodioxolo compounds that are antagonists of A2A receptor. The present invention is also directed to uses of the 2,2-difluorodioxolo compounds described herein in the potential treatment or prevention of neurological disorders and diseases in which A2A receptor are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds and to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which A2A receptors are involved.
(FR)La présente invention concerne des composés 2,2-difluorodioxolo qui sont des antagonistes du récepteur A2A. La présente invention concerne également des utilisations des composés 2,2-difluorodioxolo décrits dans le traitement potentiel ou la prévention de troubles et de maladies neurologiques dans lesquels le récepteur A2A est impliqué. L’invention concerne également sur des compositions pharmaceutiques comprenant ces composés, ainsi que des utilisations de ces compositions pharmaceutiques dans la prévention ou le traitement de telles maladies impliquant les récepteurs A2A.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)