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1. (WO2015027222) CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

What is claimed is:

1. A compound of Formula I :


Formula I

or a pharmaceutically acceptable salt thereof, wherein

X3 is C-R12, or N;

X4 is C-Ri , or N;

X5 is C-Ri4, or N;

n is 0, 1, 2, 3, 4, or 5;

m is 0, 1, 2, 3, 4, or 5;

f

A

N ~ - - - ' is aryl or heteroaryl;

' \

( - - B - - ' is aryl, heteroaryl, or heterocycloalkyl;

Re, R12, Ri3, Ri4 , and each Z is independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfmyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl;

each Q is independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfmyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy,

optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or E;

wherein E is an electrophilic group capable of forming a covalent bond with a cleophile.

The compound or pharmaceutically acceptable salt of claim 1, wherein is selected from the group consisting of: pyrrolyl, furanyl, thienyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, furazanyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazole, 1,2,5-oxadiazole, 1,3,4-oxadiazole, thiadiazolyl, dithiazolyl, tetrazolyl, pyridinyl, pyranyl, thiopyranyl, diazinyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxazinyl, thiazinyl, dioxinyl, dithiinyl, 1,2,3-triazinyl, 1,2,4-triazinyl,

1,3,5-triazinyl, tetrazinyl, and phenyl; and !·. -- B--' ,; is selected from the group consisting of: piperazinyl, morpholinyl, piperidinyl, thiomorpholinyl, pyrrolidinyl, tetrahydrofuranyl, diazepanyl, azetidinyl, oxetanyl, oxiranyl, aziridinyl, pyrrolyl, furanyl, thienyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, furazanyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazole, 1,2,5- oxadiazole, 1,3,4-oxadiazole, thiadiazolyl, dithiazolyl, tetrazolyl, pyridinyl, pyranyl, thiopyranyl, diazinyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxazinyl, thiazinyl, dioxinyl, dithiinyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, tetrazinyl, and phenyl.

' ~ " \ ' \

The compound or pharmaceutically acceptable salt of claim 2, wherein is selected from the group consisting of: phenyl, pyridinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl, pyrazolyl, isoxazolyl, and thienyl.

' \

The compound or pharmaceutically acceptable salt of claim 3, wherein ;, a is phenyl or pyridinyl.

5. The compound or pharmaceutically acceptable salt of claim 2, wherein
is selected from the group consisting of: phenyl, pyridinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl, pyrazolyl, isoxazolyl, and thienyl.

' \ ί B ,';

6. The compound or pharmaceutically acceptable salt of claim 5, wherein is phenyl or pyridinyl.

B ;

7. The compound or pharmaceutically acceptable salt of claim 2, wherein is selected from the group consisting of: piperazinyl, morpholinyl, piperidinyl, thiomorpholinyl, pyrrolidinyl, tetrahydrofuranyl, diazepanyl, azetidinyl, oxetanyl, oxiranyl, and aziridinyl.

8. The compound or pharmaceutically acceptable salt of claim 7, wherein ( B ) is selected from the group consisting of: piperazinyl, morpholinyl, piperidinyl, pyrrolidinyl, tetrahydrofuranyl, and diazepanyl.

* \ ' \

9. The compound or pharmaceutically acceptable salt of claim 8, wherein '·. B ' is selected from the group consisting of: piperazinyl, morpholinyl, piperidinyl, and pyrrolidinyl.

10. The compound or pharmaceutically acceptable salt of any one of claims 1 to 9, wherein m is 1, 2, or 3; and at least one Q is E.

11. The compound or pharmaceutically acceptable salt of any one of claims 1 to 10, wherein n is 1 and Z is optionally substituted heterocycloalkyl.

12. The compound or pharmaceutically acceptable salt of claim 11, wherein Z is optionally substituted piperazinyl.

13. The compound or pharmaceutically acceptable salt of claim 12, wherein Z is methylpiperazinyl or acetylpiperazinyl.

(Z)n

14. The compound or pharmaceutically acceptable salt of claim 1 , wherein ί A L is


Xi is C-R2, or N; and

Ri, R2, R3, R4, and R5 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfmyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl.

15.


X2 is C-R11, or N; and

R11, R7, Rs, R9, and Rio are independently, hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, oxo, sulfmyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl or E;

wherein E is an electrophilic group capable of forming a covalent bond with a nucleophile.

16. The compound of claim 1, having the structure of Formula la


Formula la

or a pharmaceutically acceptable salt thereof, wherein

Xi is C-R2, or N;

X2 is C-Rn, or N;

X3 is C-Ri2, or N;

X4 is C-R13, or N;

X5 is C-Ri4, or N;

Ri, R2, R3, R4, R5, Re, R7, R11 , Ri2, R13, and Ri4 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfmyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl;

Rs, R9, and Rio are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfmyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or E;

wherein E is an electrophilic group capable of forming a covalent bond with a nucleophile.

17. The compound or pharmaceutically acceptable salt of claim 16, wherein Ri is hydrogen, cyano, halo, hydroxy, -CONH2, optionally substituted alkoxy, or optionally substituted cycloalkyloxy.

18. The compound or pharmaceutically acceptable salt of claim 17, wherein Ri is hydrogen, cyano, fluoro, chloro, hydroxy, hydroxymethyl, -CONH2, or methoxy.

19. The compound or pharmaceutically acceptable salt of claim 16, wherein R2, R3, and R4 are independently hydrogen, cyano, halo, hydroxy, carboxy, optionally substituted alkoxy, optionally substituted lower alkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, or optionally substituted aminocarbonyl.

20. The compound or pharmaceutically acceptable salt of claim 19, wherein R2 and R4 are hydrogen, and R3 is optionally substituted heteroaryl, optionally substituted

heterocycloalkyl, or optionally substituted amino.

21. The compound or pharmaceutically acceptable salt of claim 20, wherein R2 and R4 are hydrogen, and R3 is optionally substituted morpholinyl, optionally substituted piperazinyl, optionally substituted pyrrolidinyl, optionally substituted piperidinyl, optionally substituted azetidinyl, or substituted amino.

22. The compound or pharmaceutically acceptable salt of claim 19, wherein R2 and R3 are hydrogen, and R4 is optionally substituted heteroaryl, optionally substituted

heterocycloalkyl, or optionally substituted amino.

23. The compound or pharmaceutically acceptable salt of claim 22, wherein R2 and R3 are hydrogen, and R4 is optionally substituted morpholinyl, optionally substituted piperazinyl, optioanlly substituted pyrrolidinyl, optionally substituted piperidinyl, optionally substituted azetidinyl, or substituted amino.

24. The compound or pharmaceutically acceptable salt of any one of claims 16 to 23,

wherein R5 is hydrogen, halo, cyano, optionally substituted alkoxy, or optionally substituted alkyl.

25. The compound or pharmaceutically acceptable salt of claim 24, wherein R5 is hydrogen.

26. The compound or pharmaceutically acceptable salt of any one of claims 1 to 25, wherein is hydrogen or optionally substituted amino.

27. The compound or pharmaceutically acceptable salt of claim 26, wherein R6 is hydrogen or amino.

28. The compound or pharmaceutically acceptable salt of any one of claims 16 to 27, wherein R7 and Rn are independently hydrogen, cyano, optionally substituted lower alkyl, halo, or methoxy.

29. The compound or pharmaceutically acceptable salt of claim 28, wherein R7 and Rn are independently hydrogen, cyano, fluoro, chloro, methyl, hydroxymethyl, -CH2F, or methoxy.

30. The compound or pharmaceutically acceptable salt of any one of claims 16 to 29, wherein Rs, R9, and Rio are independently hydrogen, cyano, halo, hydroxy, carboxy, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, or E; wherein E is an electrophilic group capable of forming a covalent bond with a nucleophile.

31. The compound or pharmaceutically acceptable salt of claim 30, wherein at least one of Rs, R9, and Rio is halo or optionally substituted amino.

32. The compound or pharmaceutically acceptable salt of claim 30, wherein at least one of Rs, R9, and Rio is optionally substituted alkoxy.

33. The compound or pharmaceutically acceptable salt of claim 32, wherein at least one of Rs, R9, and Rio is alkoxy substituted with optionally substituted amino or optionally substituted heterocycloalkyl.

34. The compound or pharmaceutically acceptable salt of claim 30, wherein at least one of Rs, R9, and Rio is E, where E is an electrophilic group capable of forming a covalent bond with a cysteine residue of a protein.

35. The compound or pharmaceutically acceptable salt of claim 30, wherein at least one of Rs, R9, and Rio is E; and wherein E is selected from

The compound or pharmaceutically acceptable salt of claim 35, wherein E

37. The compound or pharmaceutically acceptable salt of claim 35, wherein E is

O I

H

38. The compound or pharmaceutically acceptable salt of any claim 1 to 15, wherein at least one Q is E; wherein E is an electrophilic group capable of forming a covalent bond with a cysteine residue of a protein.

39. The compound or pharmaceutically acceptable salt of claim 38, wherein E is selected from

The com
pound or pharmaceutically acceptable salt of claim 39, wherein E

41. Th compound or pharmaceutically acceptable salt of claim 39, wherein E is


42. The compound or pharmaceutically acceptable salt of any one of claims 1 to 41,

wherein Ri2 is hydrogen, halo, cyano, -CONH2, -NHCOCH3, or optionally substituted lower alkyl.

43. The compound or pharmaceutically acceptable salt of claim 42, wherein Ri2 is hydrogen, fluoro, chloro, cyano, methyl, ethyl, propyl, -CF3, -CH2F, -CHF2, -CH2CF3, -CH2CH2F, -CH2CHF2, -CH2OH, -CONH2, -CH2CONH2, or -NHCOCH3.

44. The compound or pharmaceutically acceptable salt of any one of claims 1 to 43,

wherein Ri and R14 are independently hydrogen, cyano, optionally substituted lower alkyl, halo, or methoxy.

45. The compound or pharmaceutically acceptable salt of claim 28, wherein Ri3 and R14 are independently hydrogen, cyano, fluoro, chloro, methyl, hydroxymethyl, -CH2F, or methoxy.

46. The compound or pharmaceutically acceptable salt of any one of claims 1 to 45,

wherein X3 is C-R12, 4 is C-R13, and X5 is C-R14.

47. The compound or pharmaceutically acceptable salt of any one of claims 1 to 45,

wherein X is N, X4 is C-Ri3, and X5 is C-R14.

48. The compound or pharmaceutically acceptable salt of any one of claims 1 to 45,

wherein X3 is C-R12, X4 is N, and X5 is C-R14.

49. The compound or pharmaceutically acceptable salt of any one of claims 1 to 45,

wherein X is C-R12, X4 is C-Ri3, and X5 is N.

50. The compound or pharmaceutically acceptable salt of claim 16, wherein X1 is C-R2, X2 is C-R11, X3 is C-R12, X4 is C-Ri3, and X5 is C-R14.

51. The compound or pharmaceutically acceptable salt of claim 16, wherein Xi is N, X2 is C-R11, X3 is C-R12, X4 is C-Ri3, and X5 is C-Ri4.

52. The compound or pharmaceutically acceptable salt of claim 16, wherein X1 is C-R2, X2 is N, X is C-R12, X4 is C-R13, and X5 is C-R14.

53. The compound or pharmaceutically acceptable salt of claim 16, wherein Xi is C-R2, X2 is C-R11, X3 is N, X4 is C-Ri3, and X5 is C-R14.

54. The compound or pharmaceutically acceptable salt of claim 16, wherein X1 is C-R2, X2 is C-R11, X is C-R12, X4 is N, and X5 is C-R14.

55. The compound or pharmaceutically acceptable salt of claim 16, wherein Xi is C-R2, X2 is C-R11, X3 is C-R12, X4 is C-Ri3, and X5 is N.

56. The compound or pharmaceutically acceptable salt of claim 16, wherein X1 is N, X2 is N, X3 is C-R12, X4 is C-Ri3, and X5 is C-R14.

57. The compound or pharmaceutically acceptable salt of claim 16, wherein Xi is N, X2 is C-R11, X3 is N, X4 is C-Ri3, and X5 is C-Ri4.

58. The compound or pharmaceutically acceptable salt of claim 16, wherein X1 is C-R2, X2 is N, X3 is N, X4 is C-Ri3, and X5 is C-Ri4.

59. The compound or pharmaceutically acceptable salt of claim 16, wherein Xi is N, X2 is N, X3 is N, X4 is C-Ri3, and X5 is C-Ri4.

60. The compound or pharmaceutically acceptable salt of claim 16, having the Formula lb:


Formula lb

wherein:

Xi is N or C-R2;

each Ri, R2, R4, or R5 is independently H or halo;

R3 is optionally substituted heterocycloalkyl; and

E is an electrophilic group capable of forming a covalent bond with a nucleophile. 61. The compound or pharmaceutically acceptable salt of claim 60, having the Formula lb':


Formula lb'

62. The compound or pharmaceutically acceptable salt of any of claims 60-61, wherein Ri is hydrogen or halo.

63. The compound or pharmaceutically acceptable salt of any of claims 60-61, wherein X1 is C-R2 and R2 is hydrogen or halo.

64. The compound or pharmaceutically acceptable salt of any one of claims 60-63, wherein Xi is C-R2, and Ri and R2 are fluoro.

65. The compound or pharmaceutically acceptable salt of any of claims 60-64, wherein R3 is optionally substituted morpholinyl, optionally substituted piperazinyl, optionally substituted pyrrolidinyl, optionally substituted piperidinyl, optionally substituted azetidinyl, or substituted amino.

66. The compound or pharmaceutically acceptable salt of claim 65, wherein R3 is optionally substituted morpholinyl.

67. The compound or pharmaceutically acceptable salt of claim 65, wherein R3 is optionally substituted pyrrolidinyl.

68. The compound or pharmaceutically acceptable salt of claim 65, wherein R3 is optionally substituted piperazinyl.

69. The compound or pharmaceutically acceptable salt of claim 65, wherein R3 is optionally substituted piperidinyl.

70. The compound or pharmaceutically acceptable salt of claim 65, wherein:

R3 is piperazinyl, morpholinyl, piperidinyl, or pyrrolidinyl, optionally substituted with -Ra, -ORb, optionally substituted amino (including -NRcCORb, -NRcC02Ra,

-NRcCONRbRc, -NRbC(NRc)NRbRc, -NRbC(NCN)NRbRc, and -NRcS02Ra), halo, cyano, azido, nitro, oxo (as a substituent for cycloalkyl or heterocycloalkyl), optionally substituted acyl (such as -CORb), optionally substituted alkoxycarbonyl (such as -C02Rb), aminocarbonyl (such as -CONRbRc), -OCORb, -OC02Ra, -OCONRbRc, - OP(°)(0Rb)ORc' sulfanyl (such as SRb), sulfmyl (such as -SORa)' or sulfonyl (such as -S02Ra and -S02NRbRc),

where Ra is optionally substituted Ci-C6 alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, or optionally substituted heteroaryl; Rb is hydrogen, optionally substituted Ci-C6 alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and

Rc is hydrogen or optionally substituted C1-C4 alkyl; or

Rb and Rc, and the nitrogen to which they are attached, form an optionally substituted heterocycloalkyl group; and

where each optionally substituted group is unsubstituted or independently substituted with one or more, such as one, two, or three, substituents independently chosen from C1-C4 alkyl, aryl, heteroaryl, aryl-Ci-C4 alkyl-, heteroaryl-Ci-C4 alkyl-, Ci-C4 haloalkyl, -OC C4 alkyl, -OC C4 alkylphenyl, -C C4 alkyl-OH, -OC C4 haloalkyl,

halo, -OH, -NH2, -C1-C4 alkyl-NH2, -N(Ci-C4 alkyl)(Ci-C4 alkyl), - H(Ci-C4 alkyl), -N(Ci-C4 alkyl)(C1-C4 alkylphenyl), -NH(Ci-C4 alkylphenyl), cyano, nitro, oxo (as a substituent for cycloalkyl or heterocycloalkyl), -C02H, -C(0)OCi-C4 alkyl,

-CON(Ci-C4 alkyl)(Ci-C4 alkyl), -CONH(Ci-C4 alkyl), -CONH2, - HC(0)(Ci-C4 alkyl), -NHC(0)(phenyl), -N(d-C4 alkyl)C(0)(Ci-C4 alkyl), -N(Ci-C4

alkyl)C(0)(phenyl), -C(0)Ci-C4 alkyl, -C(0)Ci-C4 alkylphenyl, -C(0)Ci-C4 haloalkyl, -OC(0)Ci-C4 alkyl, -S02(Ci-C4 alkyl), -S02(phenyl), -S02(Ci-C4 haloalkyl), -S02NH2, -S02NH(Ci-C4 alkyl), -S02NH(phenyl), -NHS02(Ci-C4 alkyl), -NHS02(phenyl), and -NHS02(Ci-C4 haloalkyl).

The compound or pharmaceutically acceptable salt of claim 70, wherein R3 is


The compound or pharmaceutically acceptable salt of claim 71, wherein Ra is Ci-C6 alkyl, optionally substituted with Ci-C4 alkyl, aryl, heteroaryl, aryl-Ci-C4 alkyl-, heteroaryl-Ci-C4 alkyl-, Ci-C4 haloalkyl, -OCi-C4 alkyl, -OCi-C4 alkylphenyl, -Ci-C4 alkyl-OH, -OCi-C4 haloalkyl, halo, -OH, -NH2, -Ci-C4 alkyl-NH2, -N(Ci-C4 alkyl)(Ci-C4 alkyl), - H(Ci-C4 alkyl), -N(Ci-C4 alkyl)(Ci-C4 alkylphenyl), - H(Ci-C4 alkylphenyl), cyano, nitro, oxo (as a substituent for cycloalkyl or heterocycloalkyl), -C02H, -C(0)OCi-C4 alkyl, -CON(Ci-C4 alkyl)(Ci-C4 alkyl), -CONH(Ci-C4 alkyl), -CONH2, -NHC(0)(Ci-C4 alkyl), -NHC(0)(phenyl), -N(Ci-C4 alkyl)C(0)(Ci-C4 alkyl), -N(Ci-C4 alkyl)C(0)(phenyl), -C(0)Ci-C4 alkyl, -C(0)Ci-C4 alkylphenyl, -C(0)Ci-C4 haloalkyl, -OC(0)Ci-C4 alkyl, -S02(Ci-C4 alkyl), -S02(phenyl), -S02(Ci-C4 haloalkyl), -S02NH2, -S02NH(Ci-C4 alkyl), -S02NH(phenyl), -NHS02(Ci-C4 alkyl), -NHS02(phenyl), or -NHS02(Ci-C4 haloalkyl).

The compound or pharmaceutically acceptable salt of claim 72, wherein Ra is Ci-C6 alkyl, optionally substituted with -OH, halo, Ci-C4 alkyl, or -OCi-C4 alkyl.

The compound or pharmaceutically acceptable salt of claim 73, wherein Ra is -CH3, -CH2CH2OH, -CH2CH2F, -CH2CH2OMe, -CH2C(CH3)2OH, or -CH2CH(CH3)OH.

A compound or pharmaceutically acceptable salt thereof, wherein the compound is chosen from the group consisting of:

N-(3-(2-((4-(piperazin-l-yl)phenyl)amino)pyrido[3,2-d]pyrimidin-8-enyl)acetamide

N-(3-(2-((4-(piperazin-l-yl)phenyl)amino)pyrido[4,3-d]pyrimidin-8-yl)phenyl)acetamide

N-(3-(2-((4-(piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acetamide

8-(2-fluorophenyl)-N-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-2-amine

8-(2-fluorophenyl)-N-(4-morpholinophenyl)pyrido[3,2-d]pyrimidin-2-amin^

8-(2-fluorophenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidin-2-amin^

8-(5-chloro-2-fluorophenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidin-2-am

8-(3-chlorophenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(3-fluorophenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(2,6-difluorophenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(4-morpholinophenyl)pyrido[ d]pyrimidin-2-amine

8-(3-(2-morpholinoethoxy)phenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrim amine

8-(3-(2-(dimethylamino)ethoxy)phenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(4-(2-morpholinoethoxy)phenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidm amine

8-(4-(2-(dimethylamino)ethoxy)phenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(4-morpholinophenyl)pyrido[3,4-d]pyrimidin-2-amine

8-phenyl-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(2-fluorophenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(2-chlorophenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(2,6-difluorophenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(5-chloro-2-fluorophenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(3-chlorophenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine 8-(3-fluorophenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

N-(4-fluoro-3-(2-((4-(piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acetamide

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)pyri d]pyrimidin-2-amine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido [3 ,4-d]pyrimidin-2-amine

8-(3-(2-morpholinoethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(3-(2-(dimethylamino)ethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(4-(2-morpholinoethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(4-(2-(dimethylamino)ethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(4-(piperazin-l-yl)phenyl)pyrido [3 ,4-d]pyrimidin-2-amine

Nl-(l-(2-fluoroethyl)azetidin-3-yl)-N4-(8-(2-fluorophenyl)pyrido[3,4-d]pyrimidm^ yl)benzene- 1 ,4-diamine

Nl-(l-(2-fluoroethyl)azetidin-3-yl)-N4-(8-(3-(2-morpholinoethoxy)phenyl)pyrido[3,4-d]pyrimidin-2-yl)benzene- 1 ,4-diamine

Nl-(8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)pyrido[3,4-d]pyrimidin-2-yl)-N4-(l-(2-fluoroethyl)azetidin-3-yl)benzene- 1 ,4-diamine

Nl-(8-(5-chloro-2-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)-N4-(l-(2-fluoroethyl)azetidin-3-yl)benzene- 1 ,4-diamine

8-(3-aminophenyl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-(3-aminophenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(3-aminophenyl)-N-(4-(4-methylpiperazin-l-yl)phenyl)quinazolin-2-amine

N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)acetamide

N-(3-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acetamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acetamide

N-(4-morpholinophenyl)-8-phenylquinazolin-2-amine

8-(2-fluorophenyl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-(2-chlorophenyl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-(5-chloro-2-fluorophenyl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-(3-chlorophenyl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-(3-fluorophenyl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-(2,6-difluorophenyl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(4-morpholinophenyl)quinazolm amine

8-(3-(2-morpholinoethoxy)phenyl)-N-(4-morpholinophenyl)quinazolin-2-amine 8-(3-(2-(dimethylamino)ethoxy)phenyl)-N-(4-morpholinophenyl)quinazolin-2-amine 8-(4-(2-morpholinoethoxy)phenyl)-N-(4-morpholinophenyl)quinazolin-2-amine 8-(4-(2-(dimethylamino)ethoxy)phenyl)-N-(4-morpholinophenyl)quinazolin-2-amine 8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-phenyl-N-(4-(piperazin- 1 -yl)phenyl)quinazolin-2-amine

8-(2-fluorophenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(2-chlorophenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(2,6-difluorophenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(5-chloro-2-fluorophenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(3-chlorophenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(3-fluorophenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

N-(4-fluoro-3-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acetamide 8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(3-(2-morpholinoethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine 8-(3-(2-(dimethylamino)ethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(4-(2-morpholinoethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine 8-(4-(2-(dimethylamino)ethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

Nl-(l-(2-fluoroethyl)azetidin-3-yl)-N4-(8-(2-fluorophenyl)quinazolin-2-yl)benzene-1 ,4-diamine

Nl-(l-(2-fluoroethyl)azetidin-3-yl)-N4-(8-(3-(2-morpholinoethoxy)phenyl)quinazolin-2-yl)benzene- 1 ,4-diamine

N 1 -(8-(2-fluoro-5 -(2-morpholinoethoxy)phenyl)quinazolin-2-yl)-N4-( 1 -(2-fluoroethyl)azetidin-3-yl)benzene- 1 ,4-diamine

Nl-(8-(5-chloro-2-fluorophenyl)quinazolin-2-yl)-N4-(l-(2-fluoroethyl)azetidin-3-yl)benzene- 1 ,4-diamine

N-(3-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-morpholinophenyl)amino)pyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-morpholinophenyl)amino)pyrido[4,3-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[4,3-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-ethylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(piperidin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(azetidin-3-ylamino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-methylazetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

tert-butyl 3-((4-((8-(3-acrylamidophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)amino)azetidine- 1 -carboxylate

N-(3-(2-((4-((l-acetylazetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[4,3-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(piperidin-4-ylamino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-methylpiperidin-4-yl)amino)phenyl)amino)pyrido[3,4-d]pyrim yl)phenyl)acrylamide

N-(3 -(2-((4-(pyrrolidin-3 -ylamino)phenyl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)pyrido[3,4-d]pyri 8-yl)phenyl)acrylamide

(R)-N-(3 -(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)phenyl)acrylamide

(R)-N-(3 -(2-((4-(2-(aminomethyl)morpholino)phenyl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(2-(aminomethyl)morpholino)phenyl)amino)pyrido[3,4-d]pyrimi yl)phenyl)acrylamide

(R)-N-(3 -(2-((4-(3 -(aminomethyl)morpholino)phenyl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(3-(aminomethyl)morpholino)phenyl)amino)pyrido[3,4-d]pyrimi yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-morpholinophenyl)amino)pyrido[3,2-d]pyrimidin-8 yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-morpholinophenyl)amino)pyrido[4,3-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimi 8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,2-d]pyrimi 8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[4,3-d]pyrimi 8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-((l-methylazetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-((l-methylpiperidin-4-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-ethylpiperazin-l-yl)-2-methoxyphenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-(piperidin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(azetidin-3-ylamino)-2-methoxyphenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-((l-methylazetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

tert-butyl 3 -((4-((8-(3 -acrylamidophenyl)quinazolin-2-yl)amino)-3 -methoxyphenyl)amino)azetidine- 1 -carboxylate

N-(3-(2-((4-((l-acetylazetidin-3-yl)amino)-2-methoxyphenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-(piperidin-4-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-((l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((2-methoxy-4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((2-methoxy-4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(2-(hydroxymethyl)morpholino)-2-methoxyphenyl)amino)qum yl)phenyl)acrylamide

(R)-N-(3-(2-((4-(2-(hydroxymethyl)morpholino)-2-methoxyphenyl)amino)qu^ 8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-(2-(aminomethyl)morpholino)-2-methoxyphenyl)amino)qum yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(2-(aminomethyl)morpholino)-2-methoxyphenyl)amino)quinazolm yl)phenyl)acrylamide

(R)-N-(3-(2-((4-(3-(aminomethyl)morpholino)-2-methoxyphenyl)amino)qum yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(3-(aminomethyl)morpholino)-2-methoxyphenyl)amino)quinazolm yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((2-methoxy-4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-chloro-2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-chloro-2-((2-methoxy-4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-methyl-2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-morpholinophenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-ethyl-2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)acrylamide N-(3-(7-fluoro-2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-chloro-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-chloro-2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-methyl-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-ethyl-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-ethylpiperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-(piperidin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(azetidin-3-ylamino)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-((l-methylazetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

tert-butyl 3-((4-((8-(3-acrylamidophenyl)-7-fluoroquinazolin-2-yl)amino)phenyl)amino)azetidine- 1 -carboxylate

N-(3-(2-((4-((l-acetylazetidin-3-yl)amino)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-chloro-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-ethyl-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-(piperidin-4-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-((l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(7-fluoro-2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(7-fluoro-2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(7-fluoro-2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(7-fluoro-2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-(2-(aminomethyl)morpholino)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(2-(aminomethyl)morpholino)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-(3-(aminomethyl)morpholino)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(3-(aminomethyl)morpholino)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-niorpholinophenyl)amino)quinazolin-8-yl)plienyl)acrylaniide

N-(3-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylaniide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylaniide

N-(3-(2-((4-(4-ethylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)plienyl)acrylaniide

N-(3-(2-((4-(piperidin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylaniide

N-(3-(2-((4-(azetidin-3-ylamino)phenyl)amino)quinazolin-8-yl)plienyl)acrylaniide

N-(3-(2-((4-((l-methylazetidin-3-yl)amino)plienyl)aniino)quinazolin-8-yl)phenyl)acrylamide

tert-butyl 3-((4-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)phenyl)amino)azetidine- 1 -carboxylate

N-(3-(2-((4-((l-acetylazetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(piperidin-4-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamid^

(R)-N-(3-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-(2-(aminomethyl)morpholino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(2-(aminomethyl)morpholino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-(3-(aminomethyl)morpholino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-(3-(aminomethyl)morpholino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)pyrido[3,2-d]pyrimidin-8-yl)phenyl)acetamide

N-(3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)pyrido[4,3-d]pyrimidin-8-yl)phenyl)acetamide

N-(3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acetamide

8-(2-fluorophenyl)-N-(6-morpholinopyridin-3-yl)pyrido[4,3-d]pyrimidin-2-am

8-(2-fluorophenyl)-N-(6-morpholinopyridin-3-yl)pyrido[3,2-d]pyrimidin-2-am

8-(2-fluorophenyl)-N-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidin-2-am

8-(5-chloro-2-fluorophenyl)-N-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrim^ amine

8-(3-chlorophenyl)-N-(6-morpholin^

8-(3-fluorophenyl)-N-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidin-2

8-(2,6-difluorophenyl)-N-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimi

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N-(6-morpholinopyridin-3-y^ d]pyrimidin-2-amine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(6-morpholinopyridin-3-yl)pyrido [3 ,4-d]pyrimidin-2-amine

8-(3-(2-morpholinoethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidin-2-amine

8-(3-(2-(dimethylamino)ethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)pyrido[3,4 d]pyrimidin-2-amine

8-(4-(2-morpholinoethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidin-2-amine

8-(4-(2-(dimethylamino)ethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)pyrido[3,4 d]pyrimidin-2-amine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)py^ d]pyrimidin-2-amine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(6-morpholinopyridin-3-yl)pyrido [3 ,4-d]pyrimidin-2-amine

8-phenyl-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidin-2-amine 8-(2-fluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidin-2-amm 8-(2-chlorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimid 8-(2,6-difluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidm^ amine

8-(5-chloro-2-fluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimi 2-amine

8-(3-chlorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidm^

8-(3-fluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidin-2-am

N-(4-fluoro-3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim1 yl)phenyl)acetamide

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido [3 ,4-d]pyrimidin-2-amine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido [3 ,4-d]pyrimidin-2-amine

8-(3 -(2-morpholinoethoxy)phenyl)-N-(6-(piperazin- 1 -yl)pyridin-3 -yl)pyrido [3 ,4-d]pyrimidin-2-amine

8-(3-(2-(dimethylamino)ethoxy)phenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyri d]pyrimidin-2-amine

8-(4-(2-morpholinoethoxy)phenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidin-2-amine

8-(4-(2-(dimethylamino)ethoxy)phenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidin-2-amine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido [3 ,4-d]pyrimidin-2-amine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido [3 ,4-d]pyrimidin-2-amine

N2-(l-(2-fluoroethyl)azetidin-3-yl)-N5-(8-(2-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)pyridine-2,5-diamine

N2-(l-(2-fluoroethyl)azetidin-3-yl)-N5-(8-(3-(2-morpholinoethoxy)phenyl)pyrido[3,4-d]pyrimidin-2-yl)pyridine-2,5-diamine

N5-(8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)pyrido[3,4-d]pyrimidin-2-yl)-N2-(l^ fluoroethyl)azetidin-3-yl)pyridine-2,5-diamine

N5-(8-(5-chloro-2-fluorophenyl)pyrido[3,4-d]pyrimidin-2-yl)-N2-(l-(2-fluoroethyl)azetidin-3-yl)pyridine-2,5-diamine

8-(3-aminophenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(3-aminophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(3-aminophenyl)-N-(6-(4-methylpiperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

N-(3-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)acetamide

N-(3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acetamide

N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acetamide

N-(6-morpholinopyridin-3-yl)-8-phenylquinazolin-2-amine

8-(2-fluorophenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(2-chlorophenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(5-chloro-2-fluorophenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(3-chlorophenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(3-fluorophenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(2,6-difluorophenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)qum amine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(3-(2-morpholinoethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine 8-(3-(2-(dimethylamino)ethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(4-(2-morpholinoethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine 8-(4-(2-(dimethylamino)ethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N-(6-morpholinopyridin-3-yl)quinazolm amine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-phenyl-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(2-fluorophenyl)-N-(6-(piperazin- 1 -yl)pyridin-3 -yl)quinazolin-2-amine

8-(2-chlorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(2,6-difluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(5-chloro-2-fluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(3-chlorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(3-fluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

N-(4-fluoro-3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acetamide

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(3-(2-morpholinoethoxy)phenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(3-(2-(dimethylamino)ethoxy)phenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(4-(2-morpholinoethoxy)phenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(4-(2-(dimethylamino)ethoxy)pheny

2-amine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

N2-(l-(2-fluoroethyl)azetidin-3-yl)-N5-(8-(2-fluorophenyl)quinazolin-2-yl)pyridine-2, 5 -diamine

N2-(l-(2-fluoroethyl)azetidin-3-yl)-N5-(8-(3-(2-morpholinoethoxy)phenyl)quinazolin-2-yl)pyridine-2,5-diamine

N5-(8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)quinazolin-2-yl)-N2-(l-(2-fluoroethyl)azetidin-3-yl)pyridine-2,5-diamine

N5-(8-(5-chloro-2-fluorophenyl)quinazolin-2-yl)-N2-(l-(2-fluoroethyl)azetidin-3-yl)pyridine-2,5-diamine

N-(3-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((6-morpholinopyridin-3-yl)amino)pyrido[4,3-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)phenyl)acrylamide

N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,2-d]pyrim yl)phenyl)acrylamide

N-(3 -(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)pyrido [4,3 -d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(4-ethylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidm^ yl)phenyl)acrylamide

N-(3-(2-((6-(piperidin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8

yl)phenyl)acrylamide

N-(3-(2-((6-(azetidin-3-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-yl)phenyl)acrylamide

N-(3-(2-((6-((l -methyl azetidin-3-yl)amino)pyridin-3-yl)amino)pyrido [3, 4-d]pyrimidin-8-yl)phenyl)acrylamide

tert-butyl 3-((5-((8-(3-acrylamidophenyl)pyrido[3,4-d]pyrimidin-2-yl)amino)pyridin-2-yl)amino)azetidine- 1 -carboxylate

N-(3-(2-((6-((l-acetylazetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[3,4-d]pyrim 8-yl)phenyl)acrylamide

N-(3-(2-((6-((l-(2-fluoroethyl)azetidin^

d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((6-((l-(2-fluoroethyl)azetidin^

d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[4 d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(piperidin-4-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyrim^

yl)phenyl)acrylamide

N-(3-(2-((6-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyri

yl)phenyl)acrylamide

(R)-N-(3-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyrim^ yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(pyrrolidin-3-ylamin^

yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)pyri

d]pyrimidin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)pyri

d]pyrimidin-8-yl)phenyl)acrylamide

(R)-N-(3 -(2-((6-(2-(aminomethyl)morpholino)pyridin-3 -yl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(2-(aminomethyl)m

d]pyrimidin-8-yl)phenyl)acrylamide

(R)-N-(3 -(2-((6-(3 -(aminomethyl)morpholino)pyridin-3 -yl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(3-(aminomethyl)morpholino)pyridin-3-yl)amino)pyri

d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyri yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-morpholinopyridin-3-yl)amino)pyrido[3,2-d]pyrim

yl)phenyl)acrylamide

N-(3 -(2-((2-methoxy-6-morpholinopyridin-3 -yl)amino)pyrido [4,3 -d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[4,3-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3 -(2-((2-methoxy-6-(( 1 -methylazetidin-3 -yl)amino)pyridin-3 -yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxypyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3 -(2-((2-methoxy-6-(( 1 -methylpiperidin-4-yl)amino)pyridin-3 -yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-(piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(4-ethylpiperazin-l-yl)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-(piperidin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(azetidin-3-ylamino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3 -(2-((2-methoxy-6-(( 1 -methylazetidin-3 -yl)amino)pyridin-3 -yl)amino)quinazolin-8-yl)phenyl)acrylamide

tert-butyl 3-((5-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-6-methoxypyridin-2-yl)amino)azetidine- 1 -carboxylate

N-(3-(2-((6-((l-acetylazetidin-3-yl)amino)-2-methoxypyridin-3-yl)amino)quinazolin yl)phenyl)acrylamide

N-(3-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-(piperidin-4-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3 -(2-((2-methoxy-6-(( 1 -methylpiperidin-4-yl)amino)pyridin-3 -yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((2-methoxy-6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((2-methoxy-6-(pyrrolidin-3-ylam

yl)phenyl)acrylamide

(S)-N-(3 -(2-((6-(2-(hydroxymethyl)morpholino)-2-methoxypyridin-3 -yl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((6-(2-(hydroxymethyl)morpholino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((6-(2-(aminomethyl)morpholino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(2-(aminomethyl)morpholino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3 -(2-((6-(3 -(aminomethyl)morpholino)-2-methoxypyridin-3 -yl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(3-(aminomethyl)morpholino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylam

N-(3-(7-fluoro-2-((2-methoxy-6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-chloro-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylami

N-(3-(7-chloro-2-((2-methoxy-6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-methyl-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-morpholinopyridin-3-yl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-ethyl-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((6-(piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-chloro-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-chloro-2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-methyl-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-ethyl-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(4-ethylpiperazin-l-yl)pyridin-3-yl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((6-(piperidin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(azetidin-3-ylamino)pyridin-3-yl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((6-((l-methylazetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

tert-butyl 3-((5-((8-(3-acrylamidophenyl)-7-fluoroquinazolin-2-yl)amino)pyridin-2-yl)amino)azetidine- 1 -carboxylate

N-(3-(2-((6-((l-acetylazetidin-3-yl)amino)pyridin-3-yl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-chloro-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-ethyl-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((6-(piperidin-4-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((6-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)amino)quinazolin^ yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(7-fluoro-2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(7-fluoro-2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(7-fluoro-2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(7-fluoro-2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((6-(2-(aminomethyl)morpholino)pyridin-3-yl)amino)-7-fluoroqum 8-yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(2-(aminomethyl)morphoH

8-yl)phenyl)acrylamide

(R)-N-(3 -(2-((6-(3 -(aminomethyl)morpholino)pyridin-3 -yl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(3-(aminomethyl)morpholino)pyridin-3-yl)amino)-7-fluoroquinaz 8-yl)phenyl)acrylamide

N-(3-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(4-ethylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(piperidin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(azetidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-((l-methylazetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

tert-butyl 3 -((5 -((8-(3 -acrylamidophenyl)quinazolin-2-yl)amino)pyridin-2-yl)amino)azetidine- 1 -carboxylate

N-(3-(2-((6-((l-acetylazetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(piperidin-4-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3 -(2-((6-(pyrrolidin-3 -ylamino)pyridin-3 -yl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)quinazolm yl)phenyl)acrylamide

(R)-N-(3-(2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)quinazolm yl)phenyl)acrylamide

(R)-N-(3-(2-((6-(2-(aminomethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(2-(aminomethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((6-(3-(aminomethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((6-(3-(aminomethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

8-(4-aminopyridin-2-yl)-N-(4-morpholinophenyl)quinazolin-2-amine

8-(4-aminopyridin-2-yl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(4-aminopyridin-2-yl)-N-(4-(4-methylpiperazin-l-yl)phenyl)quinazolin-2-amine N-(2-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acetamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acetamide

N-(4-morpholinophenyl)-8-(pyridin-2-yl)quinazolin-2-amine

8-(4-(2-morpholinoethoxy)pyridin-2-yl)-N-(4-morpholinophenyl)quinazolin-2-am 8-(4-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(4-morpholinophenyl)quinazolm amine

8-(5-(2-morpholinoethoxy)pyridin-2-yl)-N-(4-morpholinophenyl)quinazolin-2-amine 8-(5-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(4-morpholinophenyl)quinazolin-2-amine

N-(4-(piperazin- 1 -yl)phenyl)-8-(pyridin-2-yl)quinazolin-2-amine

N-(2-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acetamide 8-(4-(2-morpholinoethoxy)pyridin-2-yl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(4-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(5-(2-morpholinoethoxy)pyridin-2-yl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

8-(5-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(4-(piperazin-l-yl)phenyl)quinazolin-2-amine

Nl-(l-(2-fluoroethyl)azetidin-3-yl)-N4-(8-(4-(2-morpholinoethoxy)pyridin-2-yl)quinazolin-2-yl)benzene- 1 ,4-diamine

N-(2-(2-((2-methoxy-4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyri 4-yl)acrylamide

N-(2-(2-((2-methoxy-4-morpholinophenyl)amino)pyrido[3,2-d]pyrimidin-8-yl)pyri 4-yl)acrylamide

N-(2-(2-((2-methoxy-4-morpholinophenyl)amino)pyrido[4,3-d]pyrimidin-8-yl)pyri 4-yl)acrylamide

N-(2-(2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,2-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-(4-methylpiperazm

8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-((l-methylazetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylam

N-(2-(2-((2-methoxy-4-((l-methylpiperidin-4-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyrid' 4-yl)acrylamide

N-(2-(2-((4-(4-ethylpiperazin-l-yl)-2-methoxyphenyl)amino)quinazolin-8-yl)pyridin-yl)acrylamide

N-(2-(2-((2-methoxy-4-(piperidin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(azetidin-3-ylamino)-2-methoxyphenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-((l-methylazetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

tert-butyl 3-((4-((8-(4-acrylamidopyridin-2-yl)quinazolin-2-yl)amino)-3-methoxyphenyl)amino)azetidine- 1 -carboxylate

N-(2-(2-((4-((l-acetylazetidin-3-yl)amino)-2-methoxyphenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxyphenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-(piperidin-4-ylamino)phenyl)amino)quinazolin-8-yl)pyridin-4 yl)acrylamide

N-(2-(2-((2-methoxy-4-((l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)pyridn^ yl)acrylamide

(R)-N-(2-(2-((2-methoxy-4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((2-methoxy-4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(2-(hydroxymethyl)morpholino)-2-methoxyphenyl)amino)qui^ yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((4-(2-(hydroxymethyl)morpholino)-2-methoxyphenyl)amino)qu^ 8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((4-(2-(aminomethyl)morpholino)-2-methoxyphenyl)amino)qum yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(2-(aminomethyl)morpholino)-2-methoxyphenyl)amino)quinazoH yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((4-(3-(aminomethyl)morpholino)-2-methoxyphenyl)amino)qum yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(3-(aminomethyl)morpholm^

yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)p^

yl)acrylamide

N-(2-(2-((4-morpholinophenyl)amino)pyrido[3,2-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-morpholinophenyl)amino)pyrido[4,3-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8 yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,2-d]pyrimidin-8 yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[4,3-d]pyrimidin-8^ yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(4-ethylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(piperidin- 1 -yl)phenyl)am

yl)acrylamide

N-(2-(2-((4-(azetidin-3-ylamino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyri yl)acrylamide

N-(2-(2-((4-((l -methyl azetidin-3-yl)amino)phenyl)amino)pyrido [3, 4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

tert-butyl 3-((4-((8-(4-acrylamidopyridin-2-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)amino)azetidine- 1 -carboxylate

N-(2-(2-((4-((l-acetylazetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,2-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[4,3-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(piperidin-4-ylamino)phenyl)am

yl)acrylamide

N-(2-(2-((4-((l-methylpiperidin-4-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidm yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(pyrrolidin-3-ylamino)phenyl)am

4-yl)acrylamide

(R)-N-(2-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)pyrido[3,4-d]pyri 8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)pyrido[3,4-d]pyri 8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((4-(2-(aminomethyl)morpholino)phenyl)amino)pyrido[3,4-d]pyrim yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(2-(aminomethyl)morpholino)phenyl)amino)pyrido[3,4-d]pyrim yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((4-(3 -(aminomethyl)morpholino)phenyl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(3-(aminomethyl)morpholino)phenyl)amino)pyrido[3,4-d]pyri yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((4-morpholinophenyl)am

N-(2-(7-fluoro-2-((2-methoxy-4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-chloro-2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylami N-(2-(7-chloro-2-((2-methoxy-4-morpholinophenyl)amino)quinazolin-8-yl)pyridin yl)acrylamide

N-(2-(7-methyl-2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-morpholinophenyl)am

yl)acrylamide

N-(2-(7-ethyl-2-((4-morpholinophenyl)am

N-(2-(7-fluoro-2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-chloro-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-chloro-2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-methyl-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-ethyl-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(4-ethylpiperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((4-(piperidin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(azetidin-3-ylamino)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((4-((l-methylazetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

tert-butyl 3-((4-((8-(4-acrylamidopyridin-2-yl)-7-fluoroquinazolin-2-yl)amino)phenyl)amino)azetidine- 1 -carboxylate

N-(2-(2-((4-((l-acetylazetidin-3-yl)amino)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-chloro-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)-7-methylquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-ethyl-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((4-(piperidin-4-ylamino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((4-((l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(7-fluoro-2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)pyri 4-yl)acrylamide

(S)-N-(2-(7-fluoro-2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)pyridm 4-yl)acrylamide

(S)-N-(2-(7-fluoro-2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)quinazol^ yl)pyridin-4-yl)acrylamide

(R)-N-(2-(7-fluoro-2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)quin yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((4-(2-(aminomethyl)morpholino)phenyl)amino)-7-fluoroquinazolm yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(2-(aminomethyl)morpholino)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((4-(3-(aminomethyl)m

yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(3-(aminomethyl)morpholino)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(4-ethylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(piperidin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide N-(2-(2-((4-(azetidin-3-ylamino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide N-(2-(2-((4-((l-methylazetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

tert-butyl 3-((4-((8-(4-acrylamidopyridin-2-yl)quinazolin-2-yl)amino)phenyl)amino)azetidine- 1 -carboxylate

N-(2-(2-((4-((l-acetylazetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(piperidin-4-ylamino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-((l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)pyridm yl)acrylamide

N-(2-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)quinazolin-8-yl)py^^ 4-yl)acrylamide

(R)-N-(2-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)quinazolin-8-yl)^ 4-yl)acrylamide

(R)-N-(2-(2-((4-(2-(aminomethyl)m

yl)acrylamide

(S)-N-(2-(2-((4-(2-(aminomethyl)morpholm^

yl)acrylamide

(R)-N-(2-(2-((4-(3-(aminomethyl)morpholino)phenyl)amino)quinazolin-8-yl)pyri yl)acrylamide

(S)-N-(2-(2-((4-(3-(aminomethyl)morpholm^

yl)acrylamide

N-(2-(2-((6-(piperazin -yl)pyridin-3-yl)am

yl)acetamide

N-(2-(2-((6-(piperazin -yl)pyridin-3-yl)am

yl)acetamide

N-(6-morpholinopyridin-3-yl)-8-(pyridin-2-yl)pyrido[4,3-d]pyrimidin-2-am N-(6-morpholinopyridin-3-yl)-8-(pyridin-2-yl)pyrido[3,2-d]pyrimidin-2-am N-(6-morpholinopyridin-3-yl)-8-(pyridin-2-yl)pyrido[3,4-d]pyrimidin-2-am 8-(4-(2-morpholinoethoxy)pyridin-2-yl)-N-(6-morpholinopyridin-3-yl)pyri d]pyrimidin-2-amine

8-(4-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(6-morpholinopyridin-3-yl)p d]pyrimidin-2-amine

8-(5-(2-morpholinoethoxy)pyridin-2-yl)-N-(6-morpholinopyridin-3-yl)pyri d]pyrimidin-2-amine

8-(5-(2-(dimethylamino)ethoxy)pyridm^

d]pyrimidin-2-amine

N-(6-(piperazin-l-yl)pyridin-3-yl)-8-(pyridin-2-yl)pyrido[3,4-d]pyrimidin-^ N-(2-(2-((6-(piperazin -yl)pyridin-3-yl)am

yl)acetamide

8-(4-(2-morpholinoethoxy)pyridin-2-yl)-N-(6-(piperazin-l-yl)pyridin-3-yi d]pyrimidin-2-amine

8-(4-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido [3 ,4-d]pyrimidin-2-amine

8-(5-(2-morpholinoethoxy)pyridin-2-yl)-N-(6-(piperazin-l-yl)pyridin-3-yl^ d]pyrimidin-2-amine

8-(5-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(6-(piperazin-l-yl)pyridin-3-yl)pyrido [3 ,4-d]pyrimidin-2-amine

N2-(l-(2-fluoroethyl)azetidin-3-yl)-N5-(8-(4-(2-morpholinoethoxy)pyridin-2-yl)pyrido[3,4-d]pyrimidin-2-yl)pyridine-2,5-diamine

8-(4-aminopyridin-2-yl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

8-(4-aminopyridin-2-yl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(4-aminopyridin-2-yl)-N-(6-(4-methylpiperazin-l-yl)pyridin-3-yl)quinazolin-2-amin

N-(2-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acetamide

N-(2-(2-((6-(piperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-4-yl)acetamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acetamide

N-(6-morpholinopyridin-3-yl)-8-(pyridin-2-yl)quinazolin-2-amine

8-(4-(2-morpholinoethoxy)pyridin-2-yl)-N-(6-morpholinopyridin-3-yl)quinazo amine

8-(4-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(6-morpholinopyridin-3-yl)quina 2-amine

8-(5-(2-morpholinoethoxy)pyridin-2-yl)-N-(6-morpholinopyridin-3-yl)quinazolm amine

8-(5-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(6-morpholinopyridin-3-yl)quinazolin-2-amine

N-(6-(piperazin-l-yl)pyridin-3-yl)-8-(pyridin-2-yl)quinazolin-2-amine

8-(4-(2-morpholinoethoxy)pyridin-2-yl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(4-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(5-(2-morpholinoethoxy)pyridin-2-yl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

8-(5-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N-(6-(piperazin-l-yl)pyridin-3-yl)quinazolin-2-amine

N2-(l-(2-fluoroethyl)azetidin-3-yl)-N5-(8-(4-(2-morpholinoethoxy)pyridin-2-yl)quinazolin-2-yl)pyridine-2,5-diamine

N-(2-(2-((2-methoxy-6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-morpholinopyridin-3-yl)amino)pyrido[3,2-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-morpholinopyridin-3-yl)amino)pyrido[4,3-d]pyrim yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,2-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[4,3-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(( 1 -methylazetidin-3 -yl)amino)pyridin-3 -yl)amino)pyrido [3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxypyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(( 1 -methylpiperidin-4-yl)amino)pyridin-3 -yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(4-ethylpiperazin-l-yl)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(piperidin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(azetidin-3-ylamino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(( 1 -methylazetidin-3 -yl)amino)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

tert-butyl 3-((5-((8-(4-acrylamidopyridin-2-yl)quinazolin-2-yl)amino)-6-methoxypyridin-2-yl)amino)azetidine- 1 -carboxylate

N-(2-(2-((6-((l-acetylazetidin-3-yl)amino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(piperidin-4-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(( 1 -methylpiperidin-4-yl)amino)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((2-methoxy-6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((2-methoxy-6-(pyrrolidin-3-ylam

yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(2-(hydroxymethyl)morpholino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(2-(hydroxymethyl)morpholino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(2-(aminomethyl)morpholino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(2-(aminomethyl)morpholino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(3-(aminomethyl)morpholino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(3-(aminomethyl)morpholino)-2-methoxypyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-morpholinopyridin-3-yl)amin^

yl)acrylamide

N-(2-(2-((6-(piperazin -yl)pyridin-3-yl)am

yl)acrylamide

N-(2-(2-((6-morpholinopyridin-3-yl)amin^

yl)acrylamide

N-(2-(2-((6-morpholinopyridin-3-yl)amin^

yl)acrylamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim

yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,2-d]pyrim

yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[4,3-d]pyri yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(4-ethylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimi

yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(piperidin-l-yl)pyridin-3-y^

yl)acrylamide

N-(2-(2-((6-(azetidin-3-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l -methyl azetidin-3-yl)amino)pyridin-3-yl)amino)pyrido [3, 4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

tert-butyl 3-((5-((8-(4-acrylamidopyridin-2-yl)pyrido[3,4-d]pyrimidin-2-yl)amino)pyridin-2-yl)amino)azetidine- 1 -carboxylate

N-(2-(2-((6-((l-acetylazetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[3,4-d]pyrim 8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[3,^ d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[3,^ d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[4,^ d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(piperidin-4-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyri

yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyri

yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyrim^ yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyrm^ yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)pyri

d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)pyri

d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(2-(aminomethyl)morpholino)pyridin-3-yl)amino)pyrido[ d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(2-(aminomethyl)morpholino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(3 -(aminomethyl)morpholino)pyridin-3 -yl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(3-(aminomethyl)morpholino)pyridin-3-yl)amino)pyri

d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((2-methoxy-6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-chloro-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-chloro-2-((2-methoxy-6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-methyl-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-morpholinopyridin-3-yl)amino)-7-methylquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-ethyl-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((6-(piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-chloro-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-chloro-2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-methyl-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-methoxy-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)-7-methylquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-ethyl-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(4-ethylpiperazin-l-yl)pyridin-3-yl)amino)-7-fluoroquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((6-(piperidin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(azetidin-3-ylamino)pyridin-3-yl)amino)-7-fluoroquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((6-((l-methylazetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

tert-butyl 3-((5-((8-(4-acrylamidopyridin-2-yl)-7-fluoroquinazolin-2-yl)amino)pyridin-2-yl)amino)azetidine- 1 -carboxylate

N-(2-(2-((6-((l-acetylazetidin-3-yl)amino)pyridin-3-yl)amino)-7-fluoroquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-chloro-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)-7-methylquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-ethyl-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((6-(piperidin-4-ylamino)p

4-yl)acrylamide

N-(2-(7-fluoro-2-((6-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)amino)quinazolm yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)pyri 4-yl)acrylamide

(R)-N-(2-(7-fluoro-2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(7-fluoro-2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(7-fluoro-2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(7-fluoro-2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(2-(aminomethyl)morpholino)pyridin-3-yl)amino)-7-fluoroqum

8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(2-(aminomethyl)morpholino)pyridin-3-yl)amino)-7-fluoroqum

8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(3-(aminomethyl)morpholino)pyridin-3-yl)amino)-7-fluoroqum

8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(3-(aminomethyl)morpholino)pyridin-3-yl)amino)-7-fluoroquin 8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylami

N-(2-(2-((6-(piperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(4-ethylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(piperidin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylam N-(2-(2-((6-(azetidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l-methylazetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridm 4-yl)acrylamide

tert-butyl 3-((5-((8-(4-acrylamidopyridin-2-yl)quinazolin-2-yl)amino)pyridin-2-yl)amino)azetidine- 1 -carboxylate

N-(2-(2-((6-((l-acetylazetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(piperidin-4-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((6-(pyrrolidin-3-ylamino)pyridm^

yl)acrylamide

(R)-N-(2-(2-((6-(pyrrolidin-3-ylamino)^

yl)acrylamide

(S)-N-(2-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin yl)acrylamide

(S)-N-(2-(2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)quinazolin yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(2-(hydroxymethyl)morpholino)pyridin-3-yl)amino)quinazolm yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(2-(aminomethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(2-(aminomethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(R)-N-(2-(2-((6-(3-(aminomethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(S)-N-(2-(2-((6-(3-(aminomethyl)morpholino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(E)-4-(dimethylamino)-N-(3-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrm 8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-(piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,2-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3 -(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)pyrido [4,3 -d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-(piperidin-l-yl)phenyl)amino)pyrido[3,4 d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-N-(3-(2-((4-((l-acetylazetidin-3-yl)amm^

yl)phenyl)-4-(dimethylamino)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3 -(2-((4-(( 1 -methylpiperidin-4-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)pyri d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

N-(3-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)propiolamide

N-(3-(2-((4-(piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)propiolamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8 yl)phenyl)propiolamide

N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)propiolamide

(E)-N-(3-(2-((4-morpholinophenyl)amino)^

enamide

(Z)-N-(3-(2-((4-morpholinophenyl)amino)p

enamide

(Z)-3-fluoro-N-(3-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-3-fluoro-N-(3-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

N-(3-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)methacrylamide

N-(3-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)ethenesulfonamide

(E)-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(Z)-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(Z)-3-fluoro-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-3-fluoro-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)methacrylamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)ethenesulfonamide

3,3-difluoro-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

3 -methyl-N-(3 -(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3 -(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-(piperidin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-N-(3-(2-((4-((l-acetylazetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3 -(2-((4-(( 1 -methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quina^ yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enam

N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)propiolamide

N-(3-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)propiolamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)propiolamide

N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)propiolamide

(E)-N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide (Z)-N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide (Z)-3-fluoro-N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-3-fluoro-N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)methacrylamide N-(3-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)ethenesulfonamide (E)-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(Z)-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(Z)-3-fluoro-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(E)-3-fluoro-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(Z)-3-fluoro-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)methacrylamide

3,3-difluoro-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

3-methyl-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-3-fluoro-N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)ethenesulfonamide

(E)-4-(dimethylamino)-N-(2-(2-((6-morpholinopyridin-3-yl)amino)pyrido[ d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)pyri d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)pyrido[3,2-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)pyrido[4,3-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(piperidin-l-yl)pyridin-3-yl)amino)pyrido[ d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-N-(2-(2-((6-((l-acetylazetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)-4-(dimethylamino)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(2-(hydroxymethyl)morpholino)pyri yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((6-morpholinopyridin-3-yl)amin^

yl)propiolamide

N-(2-(2-((6-(piperazin -yl)pyridin-3-yl)am

yl)propiolamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)pyridin-4-yl)propiolamide

N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[3,^ d]pyrimidin-8-yl)pyridin-4-yl)propiolamide

(E)-N-(2-(2-((6-morpholinopyridin-3-yl)am

yl)but-2-enamide

(Z)-N-(2-(2-((6-morpholinopyridin-3-yl)am

yl)but-2-enamide

(Z)-3-fluoro-N-(2-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)pyridin-4-yl)but-2-enamide

(E)-3-fluoro-N-(2-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((6-morpholinopyridin-3-yl)amin^

yl)methacrylamide

N-(2-(2-((6-morpholinopyridin-3-yl)am

yl)ethenesulfonamide

(E)-N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)pyridin-4-yl)but-2-enamide

(Z)-N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)pyridin-4-yl)but-2-enamide

(Z)-3-fluoro-N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,^ d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-3-fluoro-N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)pyridin-4 -yl)methacry lamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)pyridin-4-yl)ethenesulfonamide

3 ,3 -difluoro-N-(2-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

3 -methyl-N-(2-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyr^ 8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,2-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[4,3-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(piperidin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-N-(2-(2-((4-((l-acetylazetidin-3-yl)amm^

yl)pyridin-4-yl)-4-(dimethylamino)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enam

(E)-4-(dimethylamino)-N-(2-(2-((4-(( 1 -methylpiperidin-4-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enam

(E)-4-(dimethylamino)-N-(2-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)pyri d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)propiolamide

N-(2-(2-((4-(piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)p^

yl)propiolamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin

yl)pyridin-4-yl)propiolamide

N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)propiolamide

(E)-N-(2-(2-((4-morpholinophenyl)amin^

yl)but-2-enamide

(Z)-N-(2-(2-((4-morpholinophenyl)amino

yl)but-2-enamide

(Z)-3-fluoro-N-(2-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-3-fluoro-N-(2-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)methacrylamide

N-(2-(2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)ethenesulfonamide

(E)-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(Z)-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(Z)-3-fluoro-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

(E)-3-fluoro-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8 yl)pyridin-4 -yl)methacry lamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8 yl)pyridin-4-yl)ethenesulfonamide

3,3-difluoro-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

3-methyl-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimi yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(3 -(2-((6-morpholinopyridin-3 -yl)amino)pyrido [3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)pyri d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3 -(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3 -(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)pyrido[3,2-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3 -(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)pyrido[4,3-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-(p^

d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-N-(3 -(2-((6-(( 1 -acetylazetidin-3 -yl)amino)pyridin-3 -yl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3 yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-(2-(hydroxymethyl)morpholino)pyri yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

N-(3-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)propiolamide

N-(3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8 yl)phenyl)propiolamide

N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)phenyl)propiolamide

N-(3-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)propiolamide

(E)-N-(3-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(Z)-N-(3-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(Z)-3-fluoro-N-(3-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)phenyl)but-2-enamide

(E)-3-fluoro-N-(3-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)phenyl)but-2-enamide

N-(3-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)methacrylamide

N-(3-(2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)ethenesulfonamide

(E)-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim^ yl)phenyl)but-2-enamide

(Z)-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim^ yl)phenyl)but-2-enamide

(Z)-3-fluoro-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4 d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-3-fluoro-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4 d]pyrimidin-8-yl)phenyl)but-2-enamide

N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)phenyl)methacrylamide

N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrim yl)phenyl)ethenesulfonamide

3,3-difluoro-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

3 -methyl-N-(3 -(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)pyrido [3 ,4-d]pyrimidin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-morpholinopyridin-3-yl)amino)quinazolm yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8 yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(piperidin-l-yl)pyridin-3-yl)amino)quinazolin^ yl)pyridin-4-yl)but-2-enamide

(E)-N-(2-(2-((6-((l-acetylazetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)-4-(dimethylamino)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((6-(2-(hydroxymethyl)morpholino)pyri

yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)propiolam

N-(2-(2-((6-(piperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

N-(2-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

(E)-N-(2-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(Z)-N-(2-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(Z)-3-fluoro-N-(2-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-3-fluoro-N-(2-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)methacrylamide

N-(2-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)ethenesulfonamide

(E)-N-(2-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(Z)-N-(2-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(Z)-3-fluoro-N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(E)-3-fluoro-N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(Z)-3-fluoro-N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)methacrylamide

3,3-difluoro-N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

3-methyl-N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-3-fluoro-N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)ethenesulfonamide

(E)-4-(dimethylamino)-N-(2-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)p^ 4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(piperidin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-N-(2-(2-((4-((l-acetylazetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)-4-(dimethylamino)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(( 1 -methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(pyrrolidin-3-ylamino)phenyl)amino)quin yl)pyridin-4-yl)but-2-enamide

(E)-4-(dimethylamino)-N-(2-(2-((4-(2-(hydroxymethyl)morpholino)phenyl)amino)quinazolin-8-yl)pyridin-4-y

N-(2-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

N-(2-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

N-(2-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

(E)-N-(2-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide (Z)-N-(2-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide (Z)-3-fluoro-N-(2-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-3-fluoro-N-(2-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)methacrylam N-(2-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)ethenesulfonam1 (E)-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(Z)-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(Z)-3-fluoro-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(E)-3-fluoro-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(Z)-3-fluoro-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)methacrylamide

3,3-difluoro-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

3-methyl-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

(E)-3-fluoro-N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)but-2-enamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)ethenesulfonamide

(E)-4-(dimethylamino)-N-(3-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8 yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3 -(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-(piperidin-l-yl)pyridin-3-yl)amino)quinazolin-8 yl)phenyl)but-2-enamide

(E)-N-(3-(2-((6-((l-acetylazetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3 yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-(pyrrolidin-3-ylamino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-4-(dimethylamino)-N-(3-(2-((6-(2-(hydroxymethyl)morpholino)pyri

yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

N-(3-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)propiolamide

N-(3-(2-((6-(piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)propiolamide

N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)propiolamide

N-(3-(2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)propiolamide

(E)-N-(3-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(Z)-N-(3-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide (Z)-3-fluoro-N-(3-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-3-fluoro-N-(3-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

N-(3-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)methacrylam

N-(3-(2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)ethenesulfonami

(E)-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(Z)-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(Z)-3-fluoro-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(E)-3-fluoro-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(Z)-3-fluoro-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)methacrylamide

3,3-difluoro-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

3-methyl-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

(E)-3-fluoro-N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)but-2-enamide

N-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)ethenesulfonamide

8-(4-(2-morpholinoethoxy)pyridin-2-yl)-N2-(6-morpholinopyridin-3-yl)qum

2,4-diamine

8-(4-(2-morpholinoethoxy)pyridin-2-yl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)quinazoline-2,4-diamine

N2-(6-morpholinopyridin-3-yl)-8-(pyridin-2-yl)quinazoline-2,4-diamine

8-(4-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine

8-(5-(2-morpholinoethoxy)pyridin-2-yl)-N2-(6-morpholinopyridin-3-yl)qum

2,4-diamine

8-(5-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine

N2-(6-(piperazin-l-yl)pyridin-3-yl)-8-(pyridin-2-yl)quinazoline-2,4-diamine

8-(2-fluorophenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidine- 8-(5-chloro-2-fluorophenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrim^

2,4-diamine

8-(5-chloro-2-fluorophenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(3-fluorophenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-d 8-(2,6-difluorophenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimi

diamine

8-(2,6-difluorophenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidine-2,^ diamine

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(3-(2-morpholinoethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(3-(2-(dimethylamino)ethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(4-(2-morpholinoethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(4-(2-(dimethylamino)ethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N2-(6-morpholinopyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(2-fluorophenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

N2-(6-(piperazin-l-yl)pyridin-3-yl)-8-(pyridin-2-yl)pyrido[3,4-d]pyrimi

diamine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(4-(2-morpholinoethoxy)pyridin-2-yl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(4-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(5-(2-morpholinoethoxy)pyridin-2-yl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(5-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

N2-(4-(piperazin-l-yl)phenyl)-8-(pyridin-2-yl)pyrido[3,4-d]pyrimidine-2,4-dia

8-(4-(2-morpholinoethoxy)pyridin-2-yl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(4-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(5-(2-morpholinoethoxy)pyridin-2-yl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(5-(2-(dimethylamino)ethoxy)pyridin-2-yl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

N2-(4-(piperazin-l-yl)phenyl)-8-(pyridin-2-yl)quinazoline-2,4-diamine

8-(2-fluorophenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine

8-(5-chloro-2-fluorophenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine 8-(3-fluorophenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine

8-(3-fluorophenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)quinazoline-2,4-diamine 8-(2,6-difluorophenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine 8-(5-chloro-2-fluorophenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)quinazoline-2,4-diamine

8-(2,6-difluorophenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)quinazoline-2,4-diamine 8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)quinazoline-2,4-diamine

8-(5-(2-(dimethylamino)ethoxy)-2-yl)quinazoline-2,4-diamine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)quinazoline-2,4-diamine

8-(3-(2-morpholinoethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine

8-(3-(2-(dimethylamino)ethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline 2,4-diamine

8-(4-(2-morpholinoethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine

8-(4-(2-(dimethylamino)ethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline 2,4-diamine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N2-(6-morpholinopyridin-3-yl)quinazoline-2,4-diamine

8-(2-fluorophenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)quinazoline-2,4-diamine 8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N2-(6-(piperazin-l-yl)pyridin-3-yl)quinazoline-2,4-diamine

8-(2-fluorophenyl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine 8-(5-chloro-2-fluorophenyl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(3-fluorophenyl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine 8-(2,6-difluorophenyl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diami^ 8-(5-chloro-2-fluorophenyl)-N2-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidine-2,4^ diamine

8-(2,6-difluorophenyl)-N2-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N2-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N2-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(3-(2-morpholinoethoxy)phenyl)-N2-(4-2,4-diamine

8-(3-(2-(dimethylamino)ethoxy)phenyl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(4-(2-morpholinoethoxy)phenyl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyri 2,4-diamine

8-(4-(2-(dimethylamino)ethoxy)phenyl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N2-(4-morpholinophenyl)pyrido[3,4-d]pyrimidine-2,4-diamine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N2-(4-morpholinophenyl)pyrid d]pyrimidine-2,4-diamine

8-(2-fluorophenyl)-N2-(4-(piperazin-l-yl)phenyl)pyrido[3,4-d]pyrimidine-2,4-diamin^ 8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N2-(4-(piperazin-l-yl)phenyl)pyri d]pyrimidine-2,4-diamine

8-(2-fluorophenyl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(2-fluorophenyl)-N2-(4-(piperazin-l-yl)phenyl)quinazoline-2,4-diamine

8-(5-chloro-2-fluorophenyl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(5-chloro-2-fluorophenyl)-N2-(4-(piperazin-l-yl)phenyl)quinazoline-2,4-diamine

8-(3-fluorophenyl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(2,6-difluorophenyl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(2,6-difluorophenyl)-N2-(4-(piperazin-l-yl)phenyl)quinazoline-2,4-diamine

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N2-(4-morpholinophenyl)quinazoline-2,4 diamine

8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)-N2-(4-(piperazin-l-yl)phenyl)quinazoline-2,4-diamine

8-(5-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(3-(2-morpholinoethoxy)phenyl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine 8-(3-(2-(dimethylamino)ethoxy)phenyl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(4-(2-morpholinoethoxy)phenyl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine 8-(4-(2-(dimethylamino)ethoxy)phenyl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(2-fluoro-4-(2-morpholinoethoxy)phe¾

diamine

8-(4-(2-(dimethylamino)ethoxy)-2-fluorophenyl)-N2-(4-morpholinophenyl)quinazoline-2,4-diamine

8-(2-fluoro-4-(2-morpholinoethoxy)phenyl)-N2-(4-(piperazin-l-yl)phenyl)quinazoline-2,4-diamine

(E)-N-(3-(4-amino-2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(4-amino-2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(E)-N-(3-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(4-amino-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(E)-N-(3-(4-amino-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(4-amino-2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)propiolamide

N-(3-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)propiolamide

N-(3-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)ethenesulfonamide

N-(3-(4-amino-2-((4-morpholinophenyl)amino)quinazolin-8-yl)phenyl)methacrylamide

N-(3-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)methacrylamide

(E)-N-(2-(4-amino-2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)-4-(dimethylamino)but-2-enamide

N-(2-(4-amino-2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylami

N-(2-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(E)-N-(2-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)-4-(dimethylamino)but-2-enamide

N-(2-(4-amino-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(E)-N-(2-(4-amino-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)-4-(dimethylamino)but-2-e

N-(2-(4-amino-2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

N-(2-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

N-(2-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)ethenesulfonamide

(E)-N-(3-(4-amino-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(4-amino-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylam

N-(3-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(E)-N-(3-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(4-amino-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

(E)-N-(3-(4-amino-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(4-amino-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)phenyl)propiolamide

N-(3-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)propiolamide

N-(3-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)ethenesulfonamide

(E)-N-(3-(4-amino-2-((4-morpholinop

yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(4-amino-2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrim yl)phenyl)acrylamide

(E)-N-(3-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(4-amino-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[ d]pyrimidin-8-yl)phenyl)acrylamide

(E)-N-(3-(4-amino-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)-4-(dimethylam

enamide

N-(3-(4-amino-2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)propiolamide

N-(3-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrim yl)phenyl)propiolamide

N-(3-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrim yl)phenyl)ethenesulfonamide

(E)-N-(2-(4-amino-2-((4-morpholinophenyl)am

yl)pyridin-4-yl)-4-(dimethylamino)but-2-enamide

N-(2-(4-amino-2-((4-morpholinophenyl)amm^

yl)acrylamide

N-(2-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimi yl)pyridin-4-yl)acrylamide

(E)-N-(2-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)-4-(dimethylamino)but-2-enamide

N-(2-(4-amino-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

(E)-N-(2-(4-amino-2-((4-((l-(2-fluoroethyl)azetidin-3-yl)amino)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)-4-(dim

enamide

N-(2-(4-amino-2-((4-morpholinophenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyrid yl)propiolamide

N-(2-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8 yl)pyridin-4-yl)propiolamide

N-(2-(4-amino-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8 yl)pyridin-4-yl)ethenesulfonamide

(E)-N-(2-(4-amino-2-((6-morpholinopyrid

4-(dimethylamino)but-2-enamide

N-(2-(4-amino-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(E)-N-(2-(4-amino-2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-4-yl)-4-(dimethylamino)but-2-enamide

N-(2-(4-amino-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

(E)-N-(2-(4-amino-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)-4-(dimethylamino)but-2-enamide

N-(2-(4-amino-2-((6-morpholinopyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

N-(2-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)propiolamide

N-(2-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-4-yl)ethenesulfonamide

(E)-N-(3-(4-amino-2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrm yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(4-amino-2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrim

yl)phenyl)acrylamide

N-(3-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(2-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)pyridin-4-yl)acrylamide

(E)-N-(3-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(4-amino-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

(E)-N-(3-(4-amino-2-((6-((l-(2-fluoroethyl)azetidin-3-yl)amino)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)-4-(dimethylamino)but-2-enam

N-(3-(4-amino-2-((6-morpholinopyridin-3-yl)amino)pyrido[3,4-d]pyrim

yl)phenyl)propiolamide

N-(3-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)propiolamide

N-(3-(4-amino-2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)ethenesulfonamide

tert-butyl 4-(4-((8-(3 -acrylamidophenyl)quinazolin-2-yl)amino)-3 -methoxyphenyl)piperazine- 1 -carboxylate

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)pyrido[3,2-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)-2-methoxyphenyl)amino)pyrido[4,3-d]pyri 8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)-2-methoxyphenyl)amino)pyrido[3,4-d]pyri 8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)-2-m

8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)-2-methoxyphenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3 -(7-(hydroxymethyl)-2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

8-(3-acrylamidophenyl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazoline-7-carboxamide

N-(3-(7-(2-amino-2-oxoethyl)-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-acetamido-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)-7-chloroquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)-7-(2-amino-2-oxoethyl)quinazolin-8-yl)phenyl)acrylamide

2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)-8-(3-acrylamidophenyl)quinazoline-7-carboxamide

N-(3-(7-acetamido-2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-chloro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

2-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-5-(4-methylpiperazin-l-yl)benzamide

N-(3-(2-((2-(hydroxymethyl)-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)-2-fluorophenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)-2-chlorophenyl)amino)quinazolin-8-yl)phenyl)acrylamide

5-(4-acetylpiperazin-l-yl)-2-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)b enzamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)-2-(hydroxymethyl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-fluoro-3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-chloro-3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-(hydroxymethyl)-3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-methoxy-3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-(fluoromethyl)-3 -(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-chlorophenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2- (hydroxymethyl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2- (fluoromethyl)phenyl)acrylamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-methoxyphenyl)acrylamide

N-(6-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(6-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(6-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(6-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide N-(4-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide N-(4-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide N-(5-(2-((4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide N-(5-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(5-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(2-(2-((2-chloro-4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylami N-(2-(2-((2-chloro-4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-chloro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(4-acetylpiperazin-l-yl)-2-chlorophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-fluoro-4-morpholinophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylam N-(2-(2-((2-fluoro-4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(4-acetylpiperazin-l-yl)-2-fluorophenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

2-((8-(4-acrylamidopyridin-2-yl)quinazolin-2-yl)amino)-5-morpholinobenzamide 2-((8-(4-acrylamidopyridin-2-yl)quinazolin-2-yl)amino)-5-(piperazin-l-yl)benzamide 2-((8-(4-acrylamidopyridin-2-yl)quinazolin-2-yl)amino)-5-(4-methylpiperazin-l-yl)benzamide

5-(4-acetylpiperazin-l-yl)-2-((8-(4-acrylamidopyridin-2-yl)quinazolin-2-yl)amino)b enzamide

N-(2-(2-((2-(hydroxymethyl)-4-morpholinophenyl)amino)quinazolin-8-yl)pyri yl)acrylamide

N-(2-(2-((2-(hydroxymethyl)-4-(piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyri 4-yl)acrylamide

N-(2-(2-((2-(hydroxymethyl)-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((4-(4-acetylpiperazin-l-yl)-2-(hydroxymethyl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-chloro-4-(4-methylpiperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-chloro-2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-fluoro-2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(3-(2-((2-chloro-4-(4-methylpiperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-chloro-2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-(7-(2-amino-2-oxoethyl)-2-((2-chloro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(7-(2-amino-2-oxoethyl)-2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-chloro-4-(4-methylpiperazin- 1 -yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(2-(2-((2-fluoro-4-(4-methylpiperazin- 1 -yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)pyridin-4-yl)acrylamide

8-(4-acrylamidopyridin-2-yl)-2-((2-chloro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazoline-7-carboxamide

8-(4-acrylamidopyridin-2-yl)-2-((2-fluoro-4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazoline-7-carboxamide

N-(3-(7-fluoro-2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-(2-amino-2-oxoethyl)-2-((2-chloro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-(2-amino-2-oxoethyl)-2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-chloro-4-(4-methylpiperazin- 1 -yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

8-(3-acrylamidophenyl)-2-((2-chloro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazoline-7-carboxamide

8-(3-acrylamidophenyl)-2-((2-fluoro-4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazoline-7-carboxamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)oxazol-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)thiazol-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)thiophen-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)-lH-imidazol-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-(4-methylpiperazin-l-yl)-lH-imidazol-5-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-methoxy-3-(4-methylpiperazin-l-yl)-lH-pyrazol-5-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-(4-methylpiperazin-l-yl)isoxazol-5-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((5-(4-methylpiperazin-l-yl)pyrimidin-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-(4-methylpiperazin-l-yl)pyrimidin-5-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-(4-methylpiperazin-l-yl)thiazol-5-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((5-(4-methylpiperazin-l-yl)thiophen-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(5-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)oxazol-2-yl)acrylamide

N-(4-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)- 1 H-imidazol-2-yl)acrylamide

N-( 1 -methyl-5-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)- 1 H-imidazol-2-yl)acrylamide

N-(2-(2-(4-(4-methylpiperazin-l-yl)phenylamino)quinazolin-8-yl)pyrimidin-4-yl)acrylamide

N-(6-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyrimidin-4-yl)acrylamide

N-(5-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)isoxazol-3-yl)acrylamide

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-lH-pyrazol-5-yl)acrylamide

N-(2-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)thiazol-5-yl)acrylamide

N-(5-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)thiazol-2-yl)acrylamide

N-(5-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)thiophen-2-yl)acrylamide

N-(4-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)thiophen-2-yl)acrylamide

1 -(2-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)morpholino)prop-2-en-l-one

(R)- 1 -(2-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)morpholino)prop-2-en- 1 -one

(S)- 1 -(2-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)morpholino)prop-2-en- 1 -one

1 -(2-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3-yl)amino)quinazolin-8-yl)morpholino)prop-2-en- 1 -one

1 -(3-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)piperidin- 1 -yl)prop-2-en-l-one

(R)- 1 -(3-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)piperidin- 1 -yl)prop-2-en- 1 -one

(S)- 1 -(3-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)piperidin- 1 -yl)prop-2-en- 1 -one

1 -(3-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3-yl)amino)quinazolin-8-yl)piperidin-l -yl)prop-2-en- 1 -one

(R)- 1 -(3-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)piperidin-1 -yl)prop-2-en- 1 -one

(S)-l-(3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)piperidin-1 -yl)prop-2-en- 1 -one

1 -(4-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)piperidin- 1 -yl)prop-2-en-l-one

N-( 1 -(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)piperidin-4-yl)acrylamide

1 -(3-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyrrolidin- 1 -yl)prop-2-en- 1 -one

(R)- 1 -(3-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyrrolidin- 1 -yl)prop-2-en- 1 -one

(S)- 1 -(3-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyrrolidin- 1 -yl)prop-2-en- 1 -one

1 -(3-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3-yl)amino)quinazolin-8-yl)pyrrolidin-l -yl)prop-2-en- 1 -one

(S)-l-(3-(2-((6-(4-methylpiperazin-l-yl)pyrM

1 -yl)prop-2-en- 1 -one

(R)- 1 -(3-(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)pyrrolidin-1 -yl)prop-2-en- 1 -one

N-(l-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyrrolidin-3-yl)acrylamide

N-(l-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)piperidin-3-yl)acrylamide

N-(l-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)piperidin-3-yl)acrylamide

1 -(4-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)piperazin- 1 -yl)prop-2-en-l-one

N-(4-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyrimidin-2-yl)acrylamide

N-(6-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyrazin-2-yl)acrylamide

N-(3 -(2-((5 -(4-methylpiperazin- 1 -yl)pyridin-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-fluoro-3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-chloro-3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(6-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5 -(2-((6-(4-methylpiperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

tert-butyl 4-(4-((8-(2-fluorophenyl)quinazolin-2-yl)amino)phenyl)piperazine- 1 -carboxylate

tert-butyl 4-(4-((8-(2-chlorophenyl)quinazolin-2-yl)amino)phenyl)piperazine- 1 -carboxylate

tert-butyl 4-(4-((8-(3 -fluorophenyl)quinazolin-2-yl)amino)phenyl)piperazine- 1 -carboxylate

tert-butyl 4-(4-((8-(5-chloro-2-fluorophenyl)quinazolin-2-yl)amino)phenyl)piperazine-1 -carboxylate

tert-butyl 4-(4-((8-(3 -chlorophenyl)quinazolin-2-yl)amino)phenyl)piperazine- 1 -carboxylate

tert-butyl 4-(4-((8-phenylquinazolin-2-yl)amino)phenyl)piperazine- 1 -carboxylate

tert-butyl 4-(4-((8-(2-fluoro-5-(2-morpholinoethoxy)phenyl)quinazolin-2-yl)amino)phenyl)piperazine- 1 -carboxylate

N-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)propionamide

N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(4-acetylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-ethylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(3-(7-methyl-2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)propionamide

(E)-N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)-4-(dimethylamino)but-2-enamide

N-(3-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2,2-difluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(5-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(E)-N-(3-(2-((4-(4-acetylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-chlorophenyl)-4-(dimethylamino)but-2-enamide

N-(2-fluoro-3-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(E)-4-(dimethylamino)-N-(2-fluoro-3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)but-2-enamide

N-(3-(2-((4-((2-fluoroethyl)(methyl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-fluoro-3-(2-((4-((2-fluoroethyl)(methyl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((2-hydroxyethyl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide N-(4-fluoro-3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-cyano-3 -(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

l-(3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-5,6-dihydropyridin-1 (2H)-yl)prop-2-en- 1 -one

N-(3-(2-((3-chloro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-chloro-3-(2-((4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-cyano-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-methoxy-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

methyl 4-(4-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)phenyl)piperazine- 1 -carboxylate

N-(3-(2-((4-(3-(hydroxymethyl)-4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-fluoroethyl)azetidin-3-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((3-fluoro-l-methylpiperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-fluoro-3-(2-((4-((3-fluoro-l-methylpiperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((5-chloro-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxyacetyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

4-(4-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)phenyl)-N-methylpiperazine-l-carboxamide

N-(3-(2-((4-(4-propionylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

5-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-2-(4-methylpiperazin-l-yl)benzamide

N-(3-(2-((5-cyano-6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

methyl 4-(4-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)phenyl)- 1 -methylpiperazine-2-carboxylate

4-(4-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)phenyl)-l-methylpiperazine-2-carboxylic acid

N-(3-(2-((4-(2-oxooxazolidin-3-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide N-(3-(2-((4-(4-(methylsulfonyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

4-(4-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)phenyl)-l-methylpiperazine-2-carboxamide

N-(3-(2-((4-(lH-imidazol-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide N-(3-(2-((4-(3-oxomorpholino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide N-(3-(2-((4-(2-oxopyrrolidin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide N-(3-(2-((4-(2-oxoimidazolidin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide N-(3-(2-((4-(3-hydroxypyrrolidin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-hydroxyethyl)azetidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-cyano-3 -(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

methyl 2-acrylamido-6-(2-((4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)benzoate

N-(3-(2-((4-(l,4-oxazepan-4-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide methyl 2-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-5-(4-methylpiperazin- 1 -yl)benzoate

N-(3-(2-((4-((3-fluoro-l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-methyl-2-oxopiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2-methoxyethoxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2-hydroxyethoxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2-(azetidin-l-yl)ethoxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2-(dimethylamino)ethoxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((tetrahydro-2H-pyran-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-((tetrahydrofuran-3-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-((tetrahydrofuran-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-((tetrahydrofuran-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-methyl-3-oxopiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(3-oxopiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-((tetrahydrofuran-3-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-acetylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-((l-methylpyrrolidin-3-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-acetylazetidin-3-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-((l-methylpyrrolidin-3-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-acetylpiperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-methylpiperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-((l-methylpyrrolidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-((l-acetylpyrrolidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-((l-methylpyrrolidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-((l-acetylpyrrolidin-3-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((4-((l-acetylpyrrolidin-3-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((4-((l-acetylpyrrolidin-3-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((2-fluoroethyl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((2,2-difluoroethyl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-fluoroethyl)piperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-hydroxyethyl)piperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-fluoroethyl)piperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-((l-(2-hydroxyethyl)piperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-fluoro-4-((l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-fluoro-4-((l-methylpiperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3,5-difluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,6-difluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3,5-difluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,6-difluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3,5-difluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,6-difluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-chloro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-cyano-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)-2-methoxyphenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)-2-(hydroxymethyl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

2-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-5-(4-(2-hydroxyethyl)piperazin-l-yl)benzamide

N-(3-(2-((2-fluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-chloro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)-2-methoxyphenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-cyano-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)-2-(hydroxymethyl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

2-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-5-(4-(2-fluoroethyl)piperazin-l-yl)benzamide

N-(3-(2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-chloro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-cyano-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)-2-methoxyphenyl)amino)quinazolin-8-yl)phenyl)acrylamide

2-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-5-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)benzamide

N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)-2-(hydroxymethyl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-fluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-chloro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-cyano-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

2-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-5-(4-(2-hydroxypropyl)piperazin-l-yl)benzamide

N-(3-(2-((4-(4-(2-hydroxypropyl)piperazin-l-yl)-2-methoxyphenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-(hydroxymethyl)-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-(hydroxymethyl)-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-chloro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-cyano-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

5-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-2-(4-(2-hydroxyethyl)piperazin-l-yl)benzamide

N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)-3-(hydroxymethyl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-fluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-chloro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-cyano-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

5-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-2-(4-(2-fluoroethyl)piperazin-l-yl)benzamide

N-(3-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)-3-(hydroxymethyl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-chloro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-cyano-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

5-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-2-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)benzamide

N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)-3-(hydroxymethyl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-fluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-chloro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-cyano-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

5-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-2-(4-(2-hydroxypropyl)piperazin-l-yl)benzamide

N-(3-(2-((3-(hydroxymethyl)-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((3-fluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3 -(2-((3 -fluoro-4-(4-(2-hydroxypropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-fluoro-4-((l-methylpiperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-fluoro-4-((l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-fluoro-4-((l-(2-hydroxyethyl)piperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-fluoro-4-((l-(2-fluoroethyl)piperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-fluoro-4-((l-(2-hydroxyethyl)piperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-fluoro-4-((l-(2-fluoroethyl)piperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(((3R,4S)-3-fluoro-l-methylpiperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(((3S,4S)-3-fluoro-l-methylpiperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(((3S,4R)-3-fluoro-l-methylpiperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(((3R,4R)-3-fluoro-l-methylpiperidin-4-yl)oxy)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(((3R,4S)-3-fluoro-l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(((3S,4S)-3-fluoro-l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(((3S,4R)-3-fluoro-l-methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(((3R,4R)-3-fluoro- 1 -methylpiperidin-4-yl)amino)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(4-(2-hydroxyethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((5-(4-(2-hydroxyethyl)piperazin-l-yl)pyridin-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(2-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(6-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-fluoro-3-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-fluoro-3-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-fluoro-3-(2-((6-(4-(2-hydroxyethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(5-(2-((6-(4-(2-hydroxyethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(4-(2-((6-(4-(2-hydroxyethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((2-f1uoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(5-(2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(4-fluoro-3-(2-((6-(4-methylpiperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-(2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((3-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(5-(2-((3-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(3-(2-((6-(4-(2-fluoroethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((5-(4-(2-fluoroethyl)piperazin-l-yl)pyridin-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(2-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(6-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-fluoro-3-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-fluoro-3-(2-((6-(4-(2-fluoroethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(5-(2-((6-(4-(2-fluoroethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(4-(2-((6-(4-(2-fluoroethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((2-fluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((3-fluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2-fluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(5-(2-((3-fluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(3 -(2-((6-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3 -(2-((5 -(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)pyridin-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(2-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(6-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-fluoro-3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-fluoro-3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-fluoro-3-(2-((6-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(5 -(2-((6-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)pyridin-3 -yl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(4-(2-((6-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(5-(2-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(3-(2-((6-(4-(2-hydroxypropyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((5-(4-(2-hydroxypropyl)piperazin-l-yl)pyridin-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-(2-((4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin- 2- yl)acrylamide

N-(5-(2-((4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin- 3- yl)acrylamide

N-(2-(2-((4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin- 4- yl)acrylamide

N-(6-(2-((4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-fluoro-3-(2-((4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-fluoro-3-(2-((4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-fluoro-3-(2-((6-(4-(2-hydroxypropyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(5-(2-((6-(4-(2-hydroxypropyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(4-(2-((6-(4-(2-hydroxypropyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((2-fluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((3-fluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2-fluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(5-(2-((3-fluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimi yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimid^^ yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-(hydroxymethyl)-2-((4-(4-(2-hydroxypropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(4-(7-fluoro-2-((3 -fluoro-4-(4-(2-hydroxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((3 -fluoro-4-(4-(2-fluoroethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((3 -fluoro-4-(4-(2-hydroxypropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((3 -fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((3 -fluoro-4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((2-fluoro-4-(4-(2-fluoroethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((2-fluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((2-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(7-fluoro-2-((3-fluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((3-fluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((3-fluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((3-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((3-fluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((2-fluoro-4-(4-(2-hydroxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((2-fluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((2-fluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((2-fluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(R)-N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

(S)-N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3 -(2-((3 ,5 -difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,6-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,6-difluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3,5-difluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,5-difluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-chloro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-cyano-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-methoxy-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2-(hydroxymethyl)-4-(4-(2-methoxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

2-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-5-(4-(2-methoxyethyl)piperazin-l-yl)benzamide

N-(3-(2-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-chloro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((3-cyano-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

5-((8-(3-acrylamidophenyl)quinazolin-2-yl)amino)-2-(4-(2-methoxyethyl)piperazin-l-yl)benzamide

N-(3-(2-((3-(hydroxymethyl)-4-(4-(2-methoxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((6-(4-(2-methoxyethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((5-(4-(2-methoxyethyl)piperazin-l-yl)pyridin-2-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-(2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin- 3- yl)acrylamide

N-(2-(2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin- 4- yl)acrylamide

N-(6-(2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-fluoro-3-(2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(2-fluoro-3-(2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(4-fluoro-3-(2-((6-(4-(2-methoxyethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(5-(2-((6-(4-(2-methoxyethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(4-(2-((6-(4-(2-methoxyethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(2-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(5-(2-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(4-(2-((2,3 -difluoro-4-(4-(2-hydroxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(2-(2-((2,3 -difluoro-4-(4-(2-hydroxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(6-(2-((2,3 -difluoro-4-(4-(2-hydroxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-4-fluorophenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-5 -fluorophenyl)acryl amide

N-(5-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(4-(2-((2,3 -difluoro-4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2,3-difluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(2-(2-((2,3 -difluoro-4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(6-(2-((2,3 -difluoro-4-(4-methylpiperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-4-fluorophenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-5-fluorophenyl)acrylamide

N-(5-(2-((2,3-difluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(4-(2-((2,3 -difluoro-4-(4-(2-methoxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(2-(2-((2,3 -difluoro-4-(4-(2-methoxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(6-(2-((2,3 -difluoro-4-(4-(2-methoxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-4-fluorophenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(4-(2-((2,3 -difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(2-(2-((2,3 -difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(6-(2-((2,3 -difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-4-fluorophenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(4-(2-((2,3 -difluoro-4-(4-(2-hydroxypropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3-yl)acrylamide

N-(2-(2-((2,3 -difluoro-4-(4-(2-hydroxypropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(6-(2-((2,3 -difluoro-4-(4-(2-hydroxypropyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-4-fluorophenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(4-(2-((2,3 -difluoro-4-(4-(2-fluoroethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(5-(2-((2,3-difluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-3 -yl)acrylamide

N-(2-(2-((2,3 -difluoro-4-(4-(2-fluoroethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-4-yl)acrylamide

N-(6-(2-((2,3 -difluoro-4-(4-(2-fluoroethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-4-fluorophenyl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-(hydroxymethyl)-2-((4-(4-(2-methoxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(4-(7-fluoro-2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((3 -fluoro-4-(4-(2-methoxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(4-(7-fluoro-2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(7-fluoro-2-((3-fluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(7-fluoro-2-((2-fluoro-4-(4-(2-methoxyethyl)piperazin- 1 -yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(4-(2-((4-(2,3-difluoro-4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)pyrido[3,4 d]pyrimidin-8-yl)phenyl)acrylamide

N-(4-(2-((4-(2,3-difluoro-4-(2-hydroxypropyl)piperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(4-(2-((4-(2,3-difluoro-4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)phenyl)acrylamide

N-(4-(2-((4-(2,3-difluoro-4-(2-fluoroethyl)piperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)-7-methylquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)-7-(hydroxymethyl)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(2,3-difluoro-4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)pyrido^ d]pyrimidin-8-yl)phenyl)acrylamide

N-(4-(2-((4-(2,3-difluoro-4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)-7-fluoroquinazolin-8-yl)pyridin-2-yl)acrylamide

N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-5-fluorophenyl)acrylamide

N-(5-(2-((2,3-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)-2-fluorophenyl)acrylamide

N-(2-fluoro-5-(2-((6-(4-(2-methoxyethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-fluoro-5-(2-((6-(4-(2-methoxyethyl)piperazin-l-yl)pyridin-3-yl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-amino-2-oxoethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((4-(4-(2-amino-2-oxoethyl)piperazin-l-yl)-2-fluorophenyl)amino)quinazolin- 8-yl)phenyl)acrylamide

N-(3-(2-((4-(lH-pyrazol-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide N-(3-(2-((4-(lH-pyrazol-4-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide N-(3-(2-((2,5-difluoro-4-(4-methylpiperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,5-difluoro-4-(4-(2-methoxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,5-difluoro-4-(4-(2-hydroxyethyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

N-(3-(2-((2,5-difluoro-4-(4-(2-hydroxy-2-methylpropyl)piperazin-l-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide

and N-(3-(2-((4-(4-(2-amino-2-oxoethyl)piperazin-l-yl)-3-fluorophenyl)amino)quinazolin-8-yl)phenyl)acrylamide.

76. A pharmaceutically acceptable salt of any of the compounds of claims 1-75.

77. The pharmaceutically acceptable salt of claim 76, wherein the salt is a chloride,

carbonate, gluconate, benzoate, acetate, lactate, citrate, propionate, hydrogenphosphate, fumarate, succinate, or TRIS (hydroxymethyl-aminomethane), maleate, malonate, tartrate, oxalate, pamoate, or stearate salt.

78. The pharmaceutically acceptable salt of claim 77, wherein the salt is a chloride,

fumarate, malonate, maleate, acetate, lactate, citrate, succinate, or tartrate salt.

79. The pharmaceutically acceptable salt of claim 78, wherein the salt is a chloride,

fumarate, malonate, maleate, or tartrate salt.

80. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound or pharmaceutically acceptable salt of any one of claims 1 to 79.

81. A pharmaceutical composition of claim 80, wherein the composition is formulated in a form chosen from the group consisting of tablets, capsules, powders, liquids, suspensions, suppositories, and aerosols.

82. A packaged pharmaceutical composition comprising a pharmaceutical composition of claim 80 or 81 and instructions for using the composition to treat a subject suffering from cancer.

83. A method of treating cancer in a subject which comprises administering to a subject in need thereof a therapeutically effective amount of a compound or pharmaceutically acceptable salt of any one of claims 1 to 79.

84. The method of claim 83, wherein the cancer is colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, thyroid cancer, fibrosarcoma,

myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chondroma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing's tumor, leiomyosarcoma, rhabdomyosarcoma, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, thyroid cancer, sebaceous gland carcinoma, papillary carcinoma, papillary adenocarcinomas, cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell lung carcinoma, non-small cell lung cancer, bladder carcinoma, epithelial carcinoma, glioma, astrocytoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendroglioma, meningioma, melanoma, neuroblastoma, retinoblastoma, leukemia, acute lymphocytic leukemia and acute myelocytic leukemia (myeloblastic, promyelocytic, myelomonocytic, monocytic and erythroleukemia); chronic leukemia (chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia); and polycythemia vera, lymphoma (Hodgkin's

disease and non-Hodgkin's disease), multiple myeloma, Waldenstrom's macro globulinemia, or heavy chain disease.

85. The method of claim 84, wherein the cancer is non-small cell lung cancer, breast

cancer, colon cancer, thyroid cancer, or ovarian cancer.

86. A method of treating a disorder mediated by EGFR in a subject in need thereof,

comprising administering to the subject a therapeutically effective amount of a compound or pharmaceutically acceptable salt of any one of claims 1 to 79.

87. A method of treating a disorder in a subject in need thereof, comprising:

a) determining the presence or absence of a EGFR mutation in a biological sample isolated from the subject; and

b) if a EGFR mutation or double mutations are determined to be present in the subject, administering to the subject a therapeutically effective amount of a compound or pharmaceutically acceptable salt of any one of claims 1 to 79.

88. The method of claim 87, wherein the EGFR mutation is in codon 790.

89. The method of claim 87, wherein the EGFR mutation is del E746-A750, del E747- E749/A750P, del E747-S752/P753S, del E747-T751/Sins/A750P, del S752-I759, G719S, G719C, L861Q, L858R, T790M, or L858R/T790M.

90. The method of claim 87, wherein determining the presence or absence of the EGFR mutation comprises amplifying EGFR nucleic acid from the biological sample and sequencing the amplified nucleic acid.

91. The method of claim 87, wherein determining the presence or absence of the EGFR mutation comprises detecting a mutant EGFR polypeptide in the biological sample using a binding agent to a mutant EGFR polypeptide.

92. The method of claim 91, wherein the binding agent is an antibody.

93. The method of claim 87, wherein the biological sample is isolated from a tumor of the subject.

94. The method of any one of claims 86-93, wherein the disorder is cancer.

95. The method of claim 94, wherein the cancer is colon carcinoma, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, thyroid cancer, fibrosarcoma,

myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chondroma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing's tumor, leiomyosarcoma, rhabdomyosarcoma, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary carcinoma, papillary

adenocarcinomas, cystadenocarcinoma, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms' tumor, cervical cancer, testicular tumor, lung carcinoma, small cell lung carcinoma, non-small cell lung cancer, bladder carcinoma, epithelial carcinoma, glioma, astrocytoma, medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendroglioma, meningioma, melanoma, neuroblastoma, retinoblastoma, leukemia, acute lymphocytic leukemia and acute myelocytic leukemia (myeloblastic, promyelocytic, myelomonocytic, monocytic and erythroleukemia); chronic leukemia (chronic myelocytic (granulocytic) leukemia and chronic lymphocytic leukemia); and polycythemia vera, lymphoma (Hodgkin's disease and non-Hodgkin's disease), multiple myeloma, Waldenstrom's

macro globulinemia, or heavy chain disease.

96. The method of claim 95, wherein the cancer is non-small cell lung cancer, colon cancer, thyroid cancer, or ovarian cancer.

97. The method of any one of claims 83-96, further comprising administering an additional anti-cancer and/or cytotoxic agent.