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1. WO2015008229 - Autotaxin inhibitors

Publication Number WO/2015/008229
Publication Date 22.01.2015
International Application No. PCT/IB2014/063142
International Filing Date 16.07.2014
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
257
Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
04
Five-membered rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C07D 403/12 (2006.01)
C07D 401/12 (2006.01)
C07D 405/12 (2006.01)
C07D 413/12 (2006.01)
C07D 417/12 (2006.01)
C07D 257/04 (2006.01)
CPC
A61K 45/06
C07D 257/04
C07D 401/12
C07D 403/12
C07D 405/12
C07D 407/12
Applicants
  • NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • BAETTIG, Urs [CH/GB]; GB (US)
  • BEATTIE, David [GB/GB]; GB (US)
  • LEGRAND, Darren Mark [GB/GB]; GB (US)
  • LISTER, Andrew Stuart [GB/GB]; GB (US)
  • MCKENNA, Jeffrey [GB/GB]; GB (US)
  • PEARCE, David William [GB/GB]; GB (US)
  • SANDHAM, David Andrew [GB/GB]; GB (US)
  • STANLEY, Emily [GB/GB]; GB (US)
  • STEWARD, Oliver Ross [GB/GB]; GB (US)
  • THOMSON, Christopher [GB/GB]; GB (US)
Inventors
  • BAETTIG, Urs; GB
  • BEATTIE, David; GB
  • LEGRAND, Darren Mark; GB
  • LISTER, Andrew Stuart; GB
  • MCKENNA, Jeffrey; GB
  • PEARCE, David William; GB
  • SANDHAM, David Andrew; GB
  • STANLEY, Emily; GB
  • STEWARD, Oliver Ross; GB
  • THOMSON, Christopher; GB
Common Representative
  • NOVARTIS AG; Lichtstrasse 35 CH-4056 Basel, CH
Priority Data
13177062.018.07.2013EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) Autotaxin inhibitors
(FR) INHIBITEURS DE L'AUTOTAXINE
Abstract
(EN)
The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.
(FR)
L'invention concerne de nouveaux composés qui sont des inhibiteurs de l'autotaxine, des procédés de préparation de ces composés, des compositions pharmaceutiques et des médicaments les contenant, ainsi que leur utilisation dans le traitement de maladies et de troubles induits par l'autotaxine.
Also published as
Latest bibliographic data on file with the International Bureau