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1. WO2015004285 - SYSTEM GENERATING A CONSTRAINT FIELD, AND MEDICAL DEVICE IMPLEMENTING THE SAME

Publication Number WO/2015/004285
Publication Date 15.01.2015
International Application No. PCT/EP2014/064995
International Filing Date 11.07.2014
IPC
A61N 1/40 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
40Applying electric fields by inductive or capacitive coupling
A61K 41/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
CPC
A61K 41/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
A61K 9/5094
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5094Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
A61K 9/5115
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
5107Excipients; Inactive ingredients
5115Inorganic compounds
A61N 1/406
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
40Applying electric fields by inductive or capacitive coupling
403for thermotherapy, e.g. hyperthermia
406using implantable thermoseeds or injected particles for localized hyperthermia
A61N 2/004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
2Magnetotherapy
004specially adapted for a specific therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • BROSSEL, Rémy [FR]/[FR]
Inventors
  • BROSSEL, Rémy
Agents
  • ICOSA
Priority Data
13176364.112.07.2013EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYSTEM GENERATING A CONSTRAINT FIELD, AND MEDICAL DEVICE IMPLEMENTING THE SAME
(FR) SYSTÈME DE GÉNÉRATION DE CHAMP DE CONTRAINTE ET DISPOSITIF MÉDICAL METTANT EN ŒUVRE LEDIT SYSTÈME
Abstract
(EN)
The present invention relates to a system comprising (1) an injection device comprising injectable magnetizable nanoparticles and means for injecting the same, and (2) means for applying a constraint by physical and/or mechanical means to a tumor associated to an neoangiogenic network where, after having been injected, the particles are retained; the present invention also relates to a method for treating tumors, especially tumors associated with a neoangiogenic network, comprising the steps of: − injecting a composition comprising magnetizable nanoparticles; − optionally performing imaging using an imaging device to detect a concentration of nanoparticles retained in the neoangiogenic network; and − applying a means for applying a contact-free constraint onto a tumor in vivo, said means being a gradient of magnetic field and the application being directed to the tumor region.
(FR)
La présente invention concerne un système comprenant (1) un dispositif d'injection comprenant des nanoparticules magnétisables et injectables ainsi qu'un moyen permettant d'injecter lesdites nanoparticules, et (2) un moyen permettant d'appliquer une contrainte à une tumeur associée à un réseau néoangiogénique par l'intermédiaire de moyens physiques et/ou mécaniques, les nanoparticules étant retenues dans ledit réseau après l'injection; la présente invention concerne également une méthode permettant de traiter les tumeurs, et plus particulièrement les tumeurs associées à un réseau néoangiogénique, ladite méthode comprenant les étapes consistant à : - injecter une composition comprenant des nanoparticules magnétisables; - réaliser (facultatif) une imagerie en utilisant un dispositif d'imagerie afin de détecter une concentration de nanoparticules retenues dans le réseau néoangiogénique; et - appliquer un moyen permettant d'appliquer une contrainte sans contact sur une tumeur in vivo, ledit moyen étant un gradient de champ magnétique et l'application étant dirigée vers la région tumorale.
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