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Machine translation
1. (WO2014210358) METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/210358    International Application No.:    PCT/US2014/044410
Publication Date: 31.12.2014 International Filing Date: 26.06.2014
IPC:
C07K 14/005 (2006.01), C12N 15/62 (2006.01), A61K 38/16 (2006.01), A61P 31/12 (2006.01)
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 308 Bynum Hall Campus Box 4105 Chapel Hill, North Carolina 27599 (US)
Inventors: MESSER, William; (US).
BARIC, Ralph; (US).
DESILVA, Aravinda; (US).
YOUNT, Boyd; (US)
Agent: SCHWARTZMAN, Robert, A.; Myers Bigel Sibley & Sajovec, P.A. P.O. Box 37428 Raleigh, North Carolina 27627 (US)
Priority Data:
61/839,687 26.06.2013 US
Title (EN) METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES
(FR) PROCÉDÉS ET COMPOSITIONS POUR DES VACCINS CONTRE LE VIRUS DE LA DENGUE
Abstract: front page image
(EN)The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
(FR)La présente invention concerne des compositions et des procédés d'utilisation de vaccins, comprenant une glycoprotéine E du virus chimérique de la dengue qui comporte un squelette de glycoprotéine E du virus de la dengue. Ledit squelette inclut des substitutions d'acides aminés qui introduisent un épitope reconnu par un anticorps, à partir d'un sérotype du virus de la dengue différent du sérotype du virus de la dengue du squelette de la glycoprotéine E du virus de la dengue.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)