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1. (WO2014210358) METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES

Pub. No.:    WO/2014/210358    International Application No.:    PCT/US2014/044410
Publication Date: Thu Jan 01 00:59:59 CET 2015 International Filing Date: Fri Jun 27 01:59:59 CEST 2014
IPC: C07K 14/005
C12N 15/62
A61K 38/16
A61P 31/12
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Inventors: MESSER, William
BARIC, Ralph
DESILVA, Aravinda
YOUNT, Boyd
Title: METHODS AND COMPOSITIONS FOR DENGUE VIRUS VACCINES
Abstract:
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.