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1. (WO2014210209) FC VARIANTS WITH IMPROVED COMPLEMENT ACTIVATION

Pub. No.:    WO/2014/210209    International Application No.:    PCT/US2014/044169
Publication Date: Thu Jan 01 00:59:59 CET 2015 International Filing Date: Thu Jun 26 01:59:59 CEST 2014
IPC: C07K 16/00
C07K 16/28
A61K 39/00
Applicants: ABBVIE BIOTHERAPEUTICS INC.
Inventors: HINTON, Paul R.
JUAN, Veronica
Title: FC VARIANTS WITH IMPROVED COMPLEMENT ACTIVATION
Abstract:
The present disclosure relates to polypeptide variants having modified Fc domains with improved potency and efficacy in activation of complement-dependent cytotoxicity.