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1. (WO2014210168) ACTIVATION OR REACTIVATION OF ACHE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/210168 International Application No.: PCT/US2014/044116
Publication Date: 31.12.2014 International Filing Date: 25.06.2014
IPC:
A61K 31/4709 (2006.01) ,C07D 403/12 (2006.01) ,C07D 233/00 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK[US/US]; 412 Low Library, Mail Code 4308 535 West 116th Street New York, New York 10027, US
Inventors: STOJANOVIC, Milan; US
KATZ, Francine; US
LANDRY, Donald W.; US
Agent: BOCK, Joel N.; US
Priority Data:
61/839,28025.06.2013US
PCT/US2014/01172015.01.2014US
Title (EN) ACTIVATION OR REACTIVATION OF ACHE
(FR) ACTIVATION OU RÉACTIVATION DE L'ACHE
Abstract: front page image
(EN) Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.
(FR) La présente invention concerne un procédé in vitro ou in vivo d'activation ou d'inversion de l'inactivation de l'acétylcholinestérase (AChE) ou de la butyrylcholinestérase (BuchE) au moyen des composés de la présente invention. L'invention concerne également une méthode de traitement d'un patient exposé à un agent neurotoxique à l'aide ces composés. L'invention concerne en outre une méthode de traitement d'un patient souffrant d'un intoxication par organophosphate à l'aide ces composés. De plus, l'invention concerne une méthode de modulation de la signalisation et de la transmission neuronale chez un patient à l'aide ces composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)