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1. (WO2014209729) HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/209729 International Application No.: PCT/US2014/043075
Publication Date: 31.12.2014 International Filing Date: 19.06.2014
IPC:
A61K 31/343 (2006.01)
Applicants: HE, Shuwen[CN/US]; US (US)
LAI, Zhong[CN/US]; US (US)
DAI, Xing[CN/US]; US (US)
XIAO, Dong[CN/US]; US (US)
LONDON, Clare[GB/US]; US (US)
ZORN, Nicolas[US/US]; US (US)
NARGUND, Ravi[US/US]; US (US)
PALANI, Anandan[US/US]; US (US)
MCCOMAS, Casey, C.[US/US]; US (US)
LI, Peng[CN/CN]; CN (NZ, US)
PENG, Xuanjia[CN/CN]; CN (NZ, US)
MERCK SHARP & DOHME CORP.[US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
SOLL, Richard[US/CN]; CN (NZ, US)
Inventors: HE, Shuwen; US
LAI, Zhong; US
DAI, Xing; US
XIAO, Dong; US
LONDON, Clare; US
ZORN, Nicolas; US
NARGUND, Ravi; US
PALANI, Anandan; US
MCCOMAS, Casey, C.; US
LI, Peng; CN
PENG, Xuanjia; CN
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Priority Data:
PCT/CN2013/00074524.06.2013CN
Title (EN) HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C
(FR) COMPOSÉS HÉTÉROCYCLIQUES ET LEURS MÉTHODES D'UTILISATION POUR LE TRAITEMENT DE L'HÉPATITE C
Abstract: front page image
(EN) The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.(I)
(FR) La présente invention concerne des composés de formule (I) qui sont utiles en tant qu'inhibiteurs de la polymérase NS5B du virus de l'hépatite C (VHC), la synthèse de tels composés, et l'utilisation de tels composés pour l'inhibition de l'activité de la polymérase NS5B du VHC, pour le traitement ou la prévention d'infections à VHC et pour l'inhibition de la réplication virale du VHC et/ou de la production virale de VHC dans un système à base de cellules. (I)
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)