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1. (WO2014209727) SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

Pub. No.:    WO/2014/209727    International Application No.:    PCT/US2014/043072
Publication Date: Thu Jan 01 00:59:59 CET 2015 International Filing Date: Fri Jun 20 01:59:59 CEST 2014
IPC: C07D 498/04
Applicants: MERCK SHARP & DOHME CORP.
DAI, Xing
LIU, Hong
PALANI, Anandan
HE, Shuwen
NARGUND, Ravi
XIAO, Dong
ZORN, Nicolas
DANG, Qun
MCCOMAS, Casey, C.
PENG, Xuanjia
LI, Peng
SOLL, Richard
Inventors: DAI, Xing
LIU, Hong
PALANI, Anandan
HE, Shuwen
NARGUND, Ravi
XIAO, Dong
ZORN, Nicolas
DANG, Qun
MCCOMAS, Casey, C.
PENG, Xuanjia
LI, Peng
SOLL, Richard
Title: SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
Abstract:
The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system. (I)