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1. (WO2014209553) USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/209553 International Application No.: PCT/US2014/040796
Publication Date: 31.12.2014 International Filing Date: 04.06.2014
IPC:
A01K 67/027 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
Applicants: VIRGINIA COMMONWEALTH UNIVERSITY[US/US]; 800 East Leigh Street Richmond, VA 23219, US
Inventors: FISHER, Paul, B.; US
DAS, Swadesh, K.; US
DASH, Rupesh; US
SARKAR, Devanand; US
SARKAR, Siddik; US
WINDLE, Jolene; US
Agent: VAVRA, Stephanie, H.; US
Priority Data:
61/830,83704.06.2013US
Title (EN) USE OF A TRUNCATED CCN1 PROMOTER FOR CANCER DIAGNOSTICS, THERAPEUTICS AND THERANOSTICS
(FR) UTILISATION D'UN PROMOTEUR DE CCN1 TRONQUÉ POUR LE DIAGNOSTIC, LA THÉRAPEUTIQUE ET LA THÉRAGNOSTIQUE DE CANCER
Abstract:
(EN) Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1 cancer selective promoter (tCCN1-Prom) are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, and the transgenic mice are used to monitor cancer progression, e.g. in screening assays.
(FR) L'invention concerne des vecteurs recombinants, dans lesquels une expression d'un ou plusieurs éléments (par exemple, des gènes nécessaires pour une réplication virale, des agents d'imagerie pouvant être détectés, des agents thérapeutiques, etc.) est entraînée par un promoteur sélectif de cancer CCN1 tronqué (tCCN1-Prom), ainsi que des cellules et des animaux transgéniques qui contiennent de tels vecteurs. Les vecteurs sont utilisés en cancérothérapie et/ou pour le diagnostic de cancer, et les souris transgéniques sont utilisées pour surveiller une progression de cancer, par exemple dans des analyses de balayage.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)